Protein Alignment Gnptab and GNPTAB

DIOPT Version :10

• Sequence 1: NP_610469.3
• Gene: Gnptab / 35943
• FlyBaseID: FBgn0033392
• Length: 666
• Species: Drosophila melanogaster
• Sequence 2: NP_077288.2
• Gene: GNPTAB / 79158
• HGNCID: 29670
• Length: 1256
• Species: Homo sapiens
• Alignment Length: 941
• Identity: 228/941 - (24%)
• Similarity: 343/941 - (36%)
• Gaps: 374/941 - (39%)

  Fly    86 DDKYDPSRFDDKNELRYSLRSLEKHAAWIRHVYIVTNGQIPSWLDLSYERVTVVPHEVLAPDPDQ 150
            |:....|||:|..||||||||:|:||.|:|:::|||||||||||:|...|||:|.|:.:..:...
Human   315 DEDISASRFEDNEELRYSLRSIERHAPWVRNIFIVTNGQIPSWLNLDNPRVTIVTHQDVFRNLSH 379

  Fly   151 LPTFSSSAIETFLHRIPKLSKRFLYLNDDIFLGAPLYPEDLYTEAEGVRVYQAWMVPGCALDCPW 215
            ||||||.|||:.:|||..||::|:|||||:..|..::|:|.|:.::|.:||..|.||.||..||.
Human   380 LPTFSSPAIESHIHRIEGLSQKFIYLNDDVMFGKDVWPDDFYSHSKGQKVYLTWPVPNCAEGCPG 444

  Fly   216 TYIGDGACDRHCNIDACQFDGGDCSETGPAS---------------------------------- 246
            ::|.||.||:.||..||.:||||||.....|
Human   445 SWIKDGYCDKACNNSACDWDGGDCSGNSGGSRYIAGGGGTGSIGVGQPWQFGGGINSVSYCNQGC 509

  Fly   247 ---------------------DA---------------------HVIPPSKEVLE---------- 259
                                 ||                     |.|.|..|.|.
Human   510 ANSWLADKFCDQACNVLSCGFDAGDCGQDHFHELYKVILLPNQTHYIIPKGECLPYFSFAEVAKR 574

  Fly   260 ----------------------------------------------------------------- 259
                                                                             
Human   575 GVEGAYSDNPIIRHASIANKWKTIHLIMHSGMNATTIHFNLTFQNTNDEEFKMQITVEVDTREGP 639

  Fly   260 -------------VQP-AAVPQSRV--------HRFPQMGLQKLFRRSSANF------------- 289
                         |.| ..:|::.:        .|||:      |:|...|.
Human   640 KLNSTAQKGYENLVSPITLLPEAEILFEDIPKEKRFPK------FKRHDVNSTRRAQEEVKIPLV 698

  Fly   290 ------KD-----------------VMRHRNVSTLKELRRIVERFNKAKLMS---LNPELETSSS 328
                  ||                 .::..|:|....||..:.....||:.:   :..|...|..
Human   699 NISLLPKDAQLSLNTLDLQLEHGDITLKGYNLSKSALLRSFLMNSQHAKIKNQAIITDETNDSLV 763

  Fly   329 EPQTTQRH--------------------------------------------------------- 336
            .||..|.|
Human   764 APQEKQVHKSILPNSLGVSERLQRLTFPAVSVKVNGHDQGQNPPLDLETTARFRVETHTQKTIGG 828

  Fly   337 -------------------------GLRKE----------------------------------- 341
                                     |..||
Human   829 NVTKEKPPSLIVPLESQMTKEKKITGKEKENSRMEENAENHIGVTEVLLGRKLQHYTDSYLGFLP 893

  Fly   342 -------------------------DFKSS----TDIYSHSLIATNMLLNRAYGFKARHVLAHVG 377
                                     |.|::    .|.::.||...|.:||..:||.:|.|.||:.
Human   894 WEKKKYFQDLLDEEESLKTQLAYFTDSKNTGRQLKDTFADSLRYVNKILNSKFGFTSRKVPAHMP 958

  Fly   378 FLIDKDIVEAMQRRFHQQILDTAHQRFRAPTDLQYAFAYYSFLMSETKVMSVEEIFDEFDTDGSA 442
            .:||:.:::.:|..|.::...|:..:.|...|:|:||:|:.:|||..:.:::.::|||.|||.|.
Human   959 HMIDRIVMQELQDMFPEEFDKTSFHKVRHSEDMQFAFSYFYYLMSAVQPLNISQVFDEVDTDQSG 1023

  Fly   443 TWSDREVRTFLTRIYQPPLDWSAMRYFEEVVQNCTRNLGMHLKVDTVEHSTL--VYERYEDSNLP 505
            ..||||:||..|||::.||....:...|.::.||::    .|..|..:.:.:  ..|.|.|.|||
Human  1024 VLSDREIRTLATRIHELPLSLQDLTGLEHMLINCSK----MLPADITQLNNIPPTQESYYDPNLP 1084

  Fly   506 TITRDLVVRCPLLAEALAANFAVRPKYNFHVSPKRTSHSNFMMLTSNLTEVVESLDRLRRNPRKF 570
            .:|:.||..|..:.:.:...:..:.||.|.:..:  ....|.|:.:|::.||..||.:|:|||||
Human  1085 PVTKSLVTNCKPVTDKIHKAYKDKNKYRFEIMGE--EEIAFKMIRTNVSHVVGQLDDIRKNPRKF 1147

  Fly   571 NCINDNLDANRGEDNEMVRHLLEDFYLSFFPRRSKFELPPQYRNRFESWRDFQRWKR-RKRAVLV 634
            .|:|||:|.|. :|.:.|:.:|.|||.|.||..|:||||.:|||||....:.|.|:. |.:....
Human  1148 VCLNDNIDHNH-KDAQTVKAVLRDFYESMFPIPSQFELPREYRNRFLHMHELQEWRAYRDKLKFW 1211

  Fly   635 IGYGVSLLLVVCLLRFMCHHKAKLVRRCVQR 665
            ....::.|::..:..|.......|.|:...|
Human  1212 THCVLATLIMFTIFSFFAEQLIALKRKIFPR 1242

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gnptab	NP_610469.3	Stealth_CR1	64..90	CDD:465346	1/3 (33%)
		Stealth_CR2	93..200	CDD:463267	58/106 (55%)
		Notch	207..240	CDD:459658	18/32 (56%)
		Stealth_CR3	374..422	CDD:465347	14/47 (30%)
		Stealth_CR4	561..617	CDD:465348	31/55 (56%)
GNPTAB	NP_077288.2	Stealth_CR1	73..101	CDD:465346
		RRM1_GNPTAB	137..225	CDD:410178
		GlcNAc-1_reg	218..305	CDD:408237
		Stealth_CR2	322..429	CDD:463267	58/106 (55%)
		Notch	436..469	CDD:459658	18/32 (56%)
		LNR 1	438..473		19/34 (56%)
		Notch	503..535	CDD:459658	2/31 (6%)
		LNR 2	505..545		2/39 (5%)
		DMAP_binding	699..814	CDD:368923	14/114 (12%)
		Stealth_CR3	955..1003	CDD:465347	14/47 (30%)
		Stealth_CR4	1138..1194	CDD:465348	32/56 (57%)