DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8027 and Gnptab

DIOPT Version :9

Sequence 1:	NP_610469.3	Gene:	CG8027 / 35943	FlyBaseID:	FBgn0033392	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	XP_343195.3	Gene:	Gnptab / 362865	RGDID:	1564821	Length:	1228	Species:	Rattus norvegicus

Alignment Length:	911	Identity:	227/911 - (24%)
Similarity:	347/911 - (38%)	Gaps:	342/911 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 DDKYDPSRFDDKNELRYSLRSLEKHAAWIRHVYIVTNGQIPSWLDLSYERVTVVPHEVLAPDPDQ 150
            |:....|||:|..||||||||:|:||.|:|:::|||||||||||:|...|||:|.|:.:..:...
  Rat   315 DEDVSASRFEDNEELRYSLRSIERHAPWVRNIFIVTNGQIPSWLNLDNPRVTIVTHQDIFQNLSH 379

  Fly   151 LPTFSSSAIETFLHRIPKLSKRFLYLNDDIFLGAPLYPEDLYTEAEGVRVYQAWMVPGCALDCPW 215
            ||||||.|||:.:|||..||::|:|||||:..|..::|:|.|:.::|.:||..|.||.||..||.
  Rat   380 LPTFSSPAIESHIHRIEGLSQKFIYLNDDVMFGKDVWPDDFYSHSKGQKVYLTWPVPNCAEGCPG 444

  Fly   216 TYIGDGACDRHCNIDACQFDGGDCSETGPAS---------------------------------- 246
            ::|.||.||:.||..||.:||||||.....|
  Rat   445 SWIKDGYCDKACNNSACDWDGGDCSGNSAGSRYVAGGGGTGNIGVGQRWQFGGGINTISYCNQGC 509

  Fly   247 ---------------------DA---------------------HVIPPSKEVL----------- 258
                                 ||                     |.:.|..|.|
  Rat   510 ANSWLADKFCDQACNVLSCGFDAGDCGQDHFHELYKVTLLPNQTHYVVPKGEYLSYFSFANIAKR 574

  Fly   259 ---------------------------------------------------------EVQPAAVP 266
                                                                     ||....||
  Rat   575 GVEGTYSDNPIVRHASIANKWKTIHLIMHSGMNATTIYFNLTLQNSNDEEFKIQIAVEVDTREVP 639

  Fly   267 QSRVHRFPQMGLQKLF----------RRSSANFKDVMRHR------------------------- 296
            :      |....||.:          .::...|:||.:.:
  Rat   640 K------PNSTTQKTYDNLVSPVTPLPQADVPFEDVPKEKRFPRVRRPDVNATGKVQEEVKIPRV 698

  Fly   297 NVSTLKELRRI--------VER-------FNKAKLMSLNPELETS---SSEPQ------------ 331
            |:|.|.:..::        :||       :|.:|...|.|.|..|   ..:||
  Rat   699 NISLLPKEAQVRLSNLDSQLERGDITLKGYNLSKSALLRPFLRNSLDTKGKPQAGTDETKDNLEV 763

  Fly   332 ----------------------TT---------QRHGLR--------KEDF-------------- 343
                                  ||         :.|||.        ||:.
  Rat   764 PQEDPSHQRPRGFAAARRPERWTTPAETATVNGRDHGLNPPPTQPVPKENLSPLIIPPEGRMPKE 828

  Fly   344 ----------------------------------------------------------------- 343

  Rat   829 GDRDRAEGNADSHVPVNELVPGRRLQQHIPSYPGFLPWEKNKYFQDLLDEEESLKKQLAYFTDSR 893

  Fly   344 ---KSSTDIYSHSLIATNMLLNRAYGFKARHVLAHVGFLIDKDIVEAMQRRFHQQILDTAHQRFR 405
               :...|.::.||...|.:||..:||.:|.|.||:..:||:.:::.:|..|.::...|:..:.|
  Rat   894 HAGRQLKDTFADSLRYVNKILNSKFGFTSRKVPAHMPHMIDRIVMQELQDMFPEEFDKTSFHKVR 958

  Fly   406 APTDLQYAFAYYSFLMSETKVMSVEEIFDEFDTDGSATWSDREVRTFLTRIYQPPLDWSAMRYFE 470
            ...|:|:||:|:.:|||..:.:::.::|||.|||.|...||||:||..||::..||....:...|
  Rat   959 HSEDMQFAFSYFYYLMSAVQPLNLSQVFDEVDTDQSGVLSDREIRTLATRVHDLPLSLQDLTGLE 1023

  Fly   471 EVVQNCTRNLGMHLKVDTVEHSTLVYERYEDSNLPTITRDLVVRCPLLAEALAANFAVRPKYNFH 535
            .::.||::.|..:  :..:.:.....|.|.|.|||.:|:.||..|..:.:.:...:..:.||.|.
  Rat  1024 HMLINCSKLLPAN--ITQLSNIPPTQEAYYDPNLPPVTKSLVTNCKPVTDKIHKAYKDKNKYRFE 1086

  Fly   536 VSPKRTSHSNFMMLTSNLTEVVESLDRLRRNPRKFNCINDNLDANRGEDNEMVRHLLEDFYLSFF 600
            :..:  ....|.|:.:|::.||..||.:|:|||||.|:|||:|.|. :|.:.|:.:|.|||.|.|
  Rat  1087 IMGE--EEIAFKMIRTNVSHVVGQLDDIRKNPRKFVCLNDNIDHNH-KDAQTVKAVLRDFYESMF 1148

  Fly   601 PRRSKFELPPQYRNRFESWRDFQRWKR-RKRAVLVIGYGVSLLLVVCLLRFMCHHKAKLVRRCVQ 664
            |..|:||||.:|||||....:.|.|:. |.:........::.|::..:..|.......|.|:...
  Rat  1149 PIPSQFELPREYRNRFLHMHELQEWRAYRDKLKFWTHCVLATLIIFTVFSFFAEQIIALKRKIFP 1213

  Fly   665 R 665
            |
  Rat  1214 R 1214

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8027	NP_610469.3	Stealth_CR1	64..90	CDD:293706	1/3 (33%)
		Stealth_CR2	93..200	CDD:288269	58/106 (55%)
		Notch	206..240	CDD:278494	19/33 (58%)
		Stealth_CR3	374..422	CDD:293707	14/47 (30%)
		Stealth_CR4	561..616	CDD:293708	30/54 (56%)
Gnptab	XP_343195.3	Stealth_CR1	73..101	CDD:293706
		Stealth_CR2	322..429	CDD:288269	58/106 (55%)
		Notch	435..469	CDD:278494	19/33 (58%)
		Notch	503..535	CDD:278494	2/31 (6%)
		DMAP_binding	699..805	CDD:283995	18/105 (17%)
		Stealth_CR3	927..975	CDD:293707	14/47 (30%)
		Stealth_CR4	1110..1166	CDD:293708	32/56 (57%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354215
Domainoid	1	1.000	133	1.000	Domainoid score	I4914
eggNOG	1	0.900	-	-		E1_2CMK5
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	418	1.000	Inparanoid score	I1746
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D360324at33208
OrthoFinder	1	1.000	-	-		FOG0008037
OrthoInspector	1	1.000	-	-		oto96090
orthoMCL	1	0.900	-	-		OOG6_105327
Panther	1	1.100	-	-	LDO	PTHR24045
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5991
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760