DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment unpg and LHX2

DIOPT Version :9

Sequence 1:	NP_477146.1	Gene:	unpg / 35942	FlyBaseID:	FBgn0015561	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_004780.3	Gene:	LHX2 / 9355	HGNCID:	6594	Length:	406	Species:	Homo sapiens

Alignment Length:	311	Identity:	63/311 - (20%)
Similarity:	97/311 - (31%)	Gaps:	118/311 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 LPFNPAAAGVAPTDLSYRRLAELMNQDYVHSLSVHARLQHMAAAGRMHEDQANP-------GMAQ 215
            |.|.....|..|...::..:|.      ..:.:..|:...:.|||      |||       |:..
Human   167 LHFEALLQGEYPAHFNHADVAA------AAAAAAAAKSAGLGAAG------ANPLGLPYYNGVGT 219

  Fly   216 LQEPTPPQAHSSPAKSGSHSPMEPALDVGMDEDFECSGDSCSDISLTMSPRNYNGEMDKSRNGAY 280
            :|:.. |:...||.         |..|:..                      ||..:..:.|
Human   220 VQKGR-PRKRKSPG---------PGADLAA----------------------YNAALSCNEN--- 249

  Fly   281 TNSDSEDCSDDEGAQSRHEGGGMGGKDSQGNGSSSNSKSRRRRTAFTSEQLLELEREFHAKKYLS 345
               |:|....|:                   ...|:.|::|.||:|...||..::..|.......
Human   250 ---DAEHLDRDQ-------------------PYPSSQKTKRMRTSFKHHQLRTMKSYFAINHNPD 292

  Fly   346 LTERSQIATSLKLSEVQVKIWFQNRRAKWKRVKAGLTSHGLGRNGTTSGTKIVVPIPVHVNRFAV 410
            ..:..|:|....|::..:::||||.|||::|        .|.|...|...|
Human   293 AKDLKQLAQKTGLTKRVLQVWFQNARAKFRR--------NLLRQENTGVDK-------------- 335

  Fly   411 RSQHQQLEKMCLSGPKPDLRKKLSAEAIGGFEKFSGSTNAS-SPSGGPVGL 460
             |....|:....|||..:|                  :||| |||..|..|
Human   336 -STDAALQTGTPSGPASEL------------------SNASLSPSSTPTTL 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unpg	NP_477146.1	Homeobox	324..375	CDD:278475	15/50 (30%)
LHX2	NP_004780.3	LIM1_Lhx2	43..106	CDD:188853
		LIM2_Lhx2_Lhx9	111..169	CDD:188763	1/1 (100%)
		COG5576	<247..378	CDD:227863	42/187 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..270		6/38 (16%)
		Homeobox	270..323	CDD:395001	16/52 (31%)
		Nuclear localization signal. /evidence=ECO:0000255	307..323		7/15 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..374		16/73 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..406
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910