DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment unpg and NKX6-2

DIOPT Version :9

Sequence 1:	NP_477146.1	Gene:	unpg / 35942	FlyBaseID:	FBgn0015561	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_796374.2	Gene:	NKX6-2 / 84504	HGNCID:	19321	Length:	277	Species:	Homo sapiens

Alignment Length:	167	Identity:	45/167 - (26%)
Similarity:	69/167 - (41%)	Gaps:	34/167 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   303 MGGKDSQGNGSSSNSKSRRRRTAFTSEQLLELEREFHAKKYLSLTERSQIATSLKLSEVQVKIWF 367
            :.|....|.....:.|.:..|..|:.:|:..||:.|...|||:..||:::|.||.::|.|||:||
Human   132 LAGPAPAGGVLDKDGKKKHSRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWF 196

  Fly   368 QNRRAKWKRVKAGLTSHGLGRNGTTSGTKIVVPIPVHVNRFAVRSQHQQLEKMCLSGPKPD---- 428
            ||||.||::           |:.....:             |.:.|....||:.:.|...:
Human   197 QNRRTKWRK-----------RHAVEMAS-------------AKKKQDSDAEKLKVGGSDAEDDDE 237

  Fly   429 ----LRKKLSAEAIGGFEKFSGSTNAS--SPSGGPVG 459
                |......|.|....|....:|.:  ||.||..|
Human   238 YNRPLDPNSDDEKITRLLKKHKPSNLALVSPCGGGAG 274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unpg	NP_477146.1	Homeobox	324..375	CDD:278475	24/50 (48%)
NKX6-2	NP_796374.2	Repressor domain. /evidence=ECO:0000250\|UniProtKB:D3Z4R4	89..142		2/9 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	132..155		4/22 (18%)
		Homeobox	151..204	CDD:306543	25/52 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	210..250		6/52 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910