DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment unpg and SHOX

DIOPT Version :9

Sequence 1:	NP_477146.1	Gene:	unpg / 35942	FlyBaseID:	FBgn0015561	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_000442.1	Gene:	SHOX / 6473	HGNCID:	10853	Length:	292	Species:	Homo sapiens

Alignment Length:	240	Identity:	69/240 - (28%)
Similarity:	98/240 - (40%)	Gaps:	59/240 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   212 GMAQLQE-PTPPQAHSSPAKSGSHSPMEPALDVGMDEDFECSGDSCSDISLTMSPRNYNGEMDKS 275
            |:|:.:| .|...:.....:.|.|.|:....| .:|.|.|         .|.        |...:
Human    42 GLARSRELGTSDSSLQDITEGGGHCPVHLFKD-HVDNDKE---------KLK--------EFGTA 88

  Fly   276 R--NGAYTNSDSEDCSDD-EGAQSRHEGGGMGGKDSQGNGSSSNSKSRRRRTAFTSEQLLELERE 337
            |  .|.|      :|.:. |..:|..|.|            .:..|.||.||.||.|||.||||.
Human    89 RVAEGIY------ECKEKREDVKSEDEDG------------QTKLKQRRSRTNFTLEQLNELERL 135

  Fly   338 FHAKKYLSLTERSQIATSLKLSEVQVKIWFQNRRAKWKRVKAGLTSHGLGRNGTTSGTK------ 396
            |....|.....|.:::..|.|||.:|::||||||||.::.:..:      ..|...||.
Human   136 FDETHYPDAFMREELSQRLGLSEARVQVWFQNRRAKCRKQENQM------HKGVILGTANHLDAC 194

  Fly   397 IVVPIPVHVNRFAVRSQHQQLE-KMCLSG---PKPDLRKKLSAEA 437
            .|.|   :||..|:|...||:: ::.|.|   ..|.|...|:|.|
Human   195 RVAP---YVNMGALRMPFQQVQAQLQLEGVAHAHPHLHPHLAAHA 236

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unpg	NP_477146.1	Homeobox	324..375	CDD:278475	26/50 (52%)
SHOX	NP_000442.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	100..119		5/30 (17%)
		Homeobox	120..174	CDD:395001	27/53 (51%)
		SH3-binding. /evidence=ECO:0000255	242..249
		OAR	272..288	CDD:397759
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	274..287
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910