DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment unpg and NKX6-1

DIOPT Version :9

Sequence 1:	NP_477146.1	Gene:	unpg / 35942	FlyBaseID:	FBgn0015561	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_006159.2	Gene:	NKX6-1 / 4825	HGNCID:	7839	Length:	367	Species:	Homo sapiens

Alignment Length:	422	Identity:	88/422 - (20%)
Similarity:	129/422 - (30%)	Gaps:	185/422 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MERPALLQNGEIGTMESPTTRLASKPFP--KPFSIESLIANQTPATATPP---------SPPEER 54
            :..|.|.....:..|::|....|..|.|  .|.|..|..::.:|   :||         .||...
Human    17 LSSPPLAALHSMAEMKTPLYPAAYPPLPAGPPSSSSSSSSSSSP---SPPLGTHNPGGLKPPATG 78

  Fly    55 DQEQEAEQEQELSARAMVASSALGLTQFPLYNPWLHGYFAQNHERLTHLIAGGCYLPS-SPAGHP 118
            .........|:||     |::..|:... |..|.:.             :|.|..||| ||:|..
Human    79 GLSSLGSPPQQLS-----AATPHGINDI-LSRPSMP-------------VASGAALPSASPSGSS 124

  Fly   119 AAQQPQAQAQP-------------------------------QPPPPHPPTHALEKQLPPTLPHP 152
            ::....|.|..                               .||||.|.
Human   125 SSSSSSASASSASAAAAAAAAAAAAASSPAGLLAGLPRFSSLSPPPPPPG--------------- 174

  Fly   153 LDTRFLPFNPAAAGVAPTDLSYRRLAELMNQDYVHSLSVHARLQHMAAAGRMHEDQANPGMAQLQ 217
                 |.|:|:||.||......:.||||..:..:..                      ||:.|
Human   175 -----LYFSPSAAAVAAVGRYPKPLAELPGRTPIFW----------------------PGVMQ-- 210

  Fly   218 EPTPPQAHSSPAKSGSHSPMEPALDVGMDEDFECSGDSCSDISLTMSPRNYNGEMDKSRNGAYTN 282
              :||                                 ..|..|..:|
Human   211 --SPP---------------------------------WRDARLACTP----------------- 223

  Fly   283 SDSEDCSDDEGAQSRHEGGGMGGKDSQGNGSSSNSKSRRRRTAFTSEQLLELEREFHAKKYLSLT 347
                           |:|..:..||         .|.:..|..|:.:|:..||:.|...|||:..
Human   224 ---------------HQGSILLDKD---------GKRKHTRPTFSGQQIFALEKTFEQTKYLAGP 264

  Fly   348 ERSQIATSLKLSEVQVKIWFQNRRAKWKRVKA 379
            ||:::|.||.::|.|||:||||||.||::..|
Human   265 ERARLAYSLGMTESQVKVWFQNRRTKWRKKHA 296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unpg	NP_477146.1	Homeobox	324..375	CDD:278475	24/50 (48%)
NKX6-1	NP_006159.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	36..133		27/118 (23%)
		Repressor domain. /evidence=ECO:0000250	102..268		52/298 (17%)
		Homeobox	239..293	CDD:395001	26/53 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..367		1/3 (33%)
		Involved in DNA-binding. /evidence=ECO:0000250	306..367
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910