DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment unpg and ZFHX3

DIOPT Version :9

Sequence 1:	NP_477146.1	Gene:	unpg / 35942	FlyBaseID:	FBgn0015561	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_001373664.1	Gene:	ZFHX3 / 463	HGNCID:	777	Length:	3703	Species:	Homo sapiens

Alignment Length:	545	Identity:	115/545 - (21%)
Similarity:	173/545 - (31%)	Gaps:	215/545 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 QNGE-IGTME--SPTTRLASKPFP-KPFSIESLIANQT--------------------------- 41
            ||.: :..||  :||:...|.|.| :.:|..:..||.|
Human  2364 QNEDSMDAMEILTPTSSSCSTPMPSQAYSAPAPSANNTASSAFLQLTAEAEELATFNSKTEAGDE 2428

  Fly    42 -PATATPPSPPEERDQEQEAEQEQELSARAMVASSALGLTQFPLYNPWLHGYFAQNHERLTHLIA 105
             |..|..||....:.||::.:.:.||..:......    |..|             .::|..|::
Human  2429 KPKLAEAPSAQPNQTQEKQGQPKPELQQQEQPEQK----TNTP-------------QQKLPQLVS 2476

  Fly   106 GGCYLPSSPAGHPAAQQPQAQAQPQPPPPHPPTHALEKQLPPTLPHPLDTRFLPFNP-------A 163
                |||.|           |..||.|||..|       ||.:.|.|.....||..|       .
Human  2477 ----LPSLP-----------QPPPQAPPPQCP-------LPQSSPSPSQLSHLPLKPLHTSTPQQ 2519

  Fly   164 AAGVAPTDLSYR----RLA-----ELMNQDYVHSLSVHARLQHMAAAGR------MHEDQANPGM 213
            .|.:.|..:.|:    :||     .......:|.||...:..|.....|      |..|.:||.:
Human  2520 LANLPPQLIPYQCDQCKLAFPSFEHWQEHQQLHFLSAQNQFIHPQFLDRSLDMPFMLFDPSNPLL 2584

  Fly   214 A-QLQEPTPPQAHSSPAKSGSHSPMEPALDVGMDEDFECSGDSCSDISLTMSPRNYNGEMDKSRN 277
            | ||.....||.   ||.|.: ||..|                      |.:......::::..:
Human  2585 ASQLLSGAIPQI---PASSAT-SPSTP----------------------TSTMNTLKRKLEEKAS 2623

  Fly   278 GAYTNSDSEDCSDDEGAQSRHEGGGMGGKDSQGNGSSSNSKSRRRRTAFTSEQLLELEREFHAKK 342
            .:...:||                |.||::.|        :.:|.||..|.|||     |...:|
Human  2624 ASPGENDS----------------GTGGEEPQ--------RDKRLRTTITPEQL-----EILYQK 2659

  Fly   343 YL---SLTER--SQIATSLKLSEVQVKIWFQNRRAKWK-----------------------RVKA 379
            ||   :.|.:  ..||..:.|.:..|::||||.||:.:                       :.|.
Human  2660 YLLDSNPTRKMLDHIAHEVGLKKRVVQVWFQNTRARERKGQFRAVGPAQAHRRCPFCRALFKAKT 2724

  Fly   380 GLTSHGLGRNGTTSGTKIVVPIPVHVNRFAVRSQHQQLEKMCLSGPKPDLRKKLSA---EAIGGF 441
            .|.:|                         :||:|....|      :......|||   :..||.
Human  2725 ALEAH-------------------------IRSRHWHEAK------RAGYNLTLSAMLLDCDGGL 2758

  Fly   442 EK----FSGSTNASSPSGGPVGLGV 462
            :.    |.|::.:..|.....|.||
Human  2759 QMKGDIFDGTSFSHLPPSSSDGQGV 2783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unpg	NP_477146.1	Homeobox	324..375	CDD:278475	20/55 (36%)
ZFHX3	NP_001373664.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..78
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	96..128
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	417..536
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	588..619
		C2H2 Zn finger	673..693	CDD:275368
		C2H2 Zn finger	728..745	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1148..1214
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1303..1354
		C2H2 Zn finger	1362..1385	CDD:275368
		C2H2 Zn finger	1403..1423	CDD:275371
		C2H2 Zn finger	1431..1452	CDD:275371
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1490..1529
		C2H2 Zn finger	1547..1571	CDD:275368
		C2H2 Zn finger	1598..1616	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1629..1727
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1865..1938
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2030..2082
		HOX	2145..2201	CDD:197696
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2204..2244
		Homeobox	2245..2299	CDD:395001
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2376..2400		7/23 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2422..2520		30/136 (22%)
		COG5576	2594..2738	CDD:227863	43/223 (19%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:24651376	2615..2617		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2619..2647		8/51 (16%)
		Homeobox	2645..2698	CDD:395001	21/57 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2771..2796		4/13 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2841..2871
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2912..2947
		Homeobox	2950..3003	CDD:395001
		Herpes_BLLF1	<3104..>3191	CDD:282904
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3137..3267
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3386..3449
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3565..3703
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910