DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment unpg and LMX1A

DIOPT Version :9

Sequence 1:	NP_477146.1	Gene:	unpg / 35942	FlyBaseID:	FBgn0015561	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_001167540.1	Gene:	LMX1A / 4009	HGNCID:	6653	Length:	382	Species:	Homo sapiens

Alignment Length:	249	Identity:	53/249 - (21%)
Similarity:	78/249 - (31%)	Gaps:	99/249 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   251 CSGDSCSDISLTMSPRNYNGEMDKSRNGAYTNSDSEDCSDDEGAQSRHEGGGMG----GKDSQGN 311
            |.||             |..|.:.....:...|||....|:|.......|.|.|    |||
Human   144 CKGD-------------YEKERELLSLVSPAASDSGKSDDEESLCKSAHGAGKGTAEEGKD---- 191

  Fly   312 GSSSNSKSRRRRTAFTSEQLLELEREFHAKKYLSLTERSQIATSLKLSEVQVKIWFQNRRAKWKR 376
                :.:.:|.||..|::|....:..|..........|..:|....||...|::||||:|||.|:
Human   192 ----HKRPKRPRTILTTQQRRAFKASFEVSSKPCRKVRETLAAETGLSVRVVQVWFQNQRAKMKK 252

  Fly   377 VKAGLTSHGLGRNGTTSGTKIVVPIPVHVNRFAVRSQHQQLEKMCLSGPKPDLRKKLSAEAIGGF 441
            :                               |.|.|.||.::        ...::||
Human   253 L-------------------------------ARRQQQQQQDQ--------QNTQRLS------- 271

  Fly   442 EKFSGSTNASSPSGGPVGLGVGVGVGVGVGLGVSTP----------LSLARSIY 485
               |..||    .||..|:.           |:..|          |::.:|:|
Human   272 ---SAQTN----GGGSAGME-----------GIMNPYTALPTPQQLLAIEQSVY 307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unpg	NP_477146.1	Homeobox	324..375	CDD:278475	16/50 (32%)
LMX1A	NP_001167540.1	LIM1_Lmx1a	35..86	CDD:188756
		LIM2_Lmx1a_Lmx1b	94..148	CDD:188764	3/16 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	161..208		16/54 (30%)
		Homeobox	198..252	CDD:395001	17/53 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	252..285		13/96 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910