Protein Alignment unpg and HMX1

DIOPT Version :10

• Sequence 1: NP_477146.1
• Gene: unpg / 35942
• FlyBaseID: FBgn0015561
• Length: 485
• Species: Drosophila melanogaster
• Sequence 2: NP_061815.2
• Gene: HMX1 / 3166
• HGNCID: 5017
• Length: 348
• Species: Homo sapiens
• Alignment Length: 441
• Identity: 103/441 - (23%)
• Similarity: 152/441 - (34%)
• Gaps: 160/441 - (36%)

  Fly    31 FSIESLIANQTP----ATATPPSPPEERDQEQEAEQEQELSARAMVASSALGLTQFPLYNPWLHG 91
            |.||:|:|.:..    ||....|..:|.:.:.:.|.|....||
Human    19 FLIENLLAAEAKGAGRATQGDGSREDEEEDDDDPEDEDAEQAR---------------------- 61

  Fly    92 YFAQNHERLTHLIAGGCYLPSSPAGHPAAQQ---PQAQA-QPQPPP-PHPPTHALEKQLPPTLPH 151
              .:..:|...|:||     :.|.|...|:.   |.|.. .|:||| |.|
Human    62 --RRRLQRRRQLLAG-----TGPGGEARARALLGPGALGLGPRPPPGPGP--------------- 104

  Fly   152 PLDTRFLPFNPAAAGVAPTDLSYRRLAELMNQDYVHSLSVHARLQHMAAAGRMHEDQANPGMAQL 216
                   ||.....|                                  |.|.:
Human   105 -------PFALGCGG----------------------------------AARWY----------- 117

  Fly   217 QEPTPPQAHS------SPAKSGSHSPMEPALDVGMDEDFECSGDSCSDISLTMSPRNYNGEMDKS 275
                 |:||.      ||..|...|| |...::|..|.....|.....:      :....|: .:
Human   118 -----PRAHGGYGGGLSPDTSDRDSP-ETGEEMGRAEGAWPRGPGPGAV------QREAAEL-AA 169

  Fly   276 RNGAYTNSDSEDCSDDEGAQSRHEGG-GMGGKDSQGNGSSSNSKSRRRRTAFTSEQLLELEREFH 339
            |..|....::.:.::...|.....|| |:||           .:.::.||.|:..|:.:||..|.
Human   170 RGPAAGTEEASELAEVPAAAGETRGGVGVGG-----------GRKKKTRTVFSRSQVFQLESTFD 223

  Fly   340 AKKYLSLTERSQIATSLKLSEVQVKIWFQNRRAKWKR-VKAGLTSHGLGRNGTTSGTKIVVPIPV 403
            .|:|||..||:.:|.||:|:|.||||||||||.|||| :.|.|.:..|    :..|.:.:|.:||
Human   224 LKRYLSSAERAGLAASLQLTETQVKIWFQNRRNKWKRQLAAELEAASL----SPPGAQRLVRVPV 284

  Fly   404 HVNRFAVRSQHQQLEKMCLSGPKPDLRKKLSAEA-------IGGFEKFSGS 447
                    ..|:.......:||...|...|:..|       :|    |||:
Human   285 --------LYHESPPAAAAAGPPATLPFPLAPAAPAPPPPLLG----FSGA 323

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unpg	NP_477146.1	Homeodomain	324..376	CDD:459649	29/51 (57%)
HMX1	NP_061815.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	29..203		49/293 (17%)
		Homeodomain	206..260	CDD:459649	30/53 (57%)
		HMX family specific domain 1	263..273		3/13 (23%)
		HMX family specific domain 2	276..289		4/20 (20%)