DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment unpg and hoxb3a

DIOPT Version :9

Sequence 1:	NP_477146.1	Gene:	unpg / 35942	FlyBaseID:	FBgn0015561	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_571192.2	Gene:	hoxb3a / 30339	ZFINID:	ZDB-GENE-990415-104	Length:	417	Species:	Danio rerio

Alignment Length:	451	Identity:	97/451 - (21%)
Similarity:	150/451 - (33%)	Gaps:	172/451 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 PSPPEERDQEQEAEQEQELSARAMVASSALGLTQFPLYNPWLHGYFAQNHERLTHLIAGGCYLPS 112
            |:|..:.....|.:.:     |:..:..:||.:..|           |.....|..:.|.|..||
Zfish    29 PAPAFQNSAHLEGDYQ-----RSACSLQSLGTSAPP-----------QPQHAKTKELNGSCMRPS 77

  Fly   113 SPAGHPAAQQPQAQAQPQPPPPH-----PPTHALEKQLPPTLPHPLDTRFLPFNPAAAGVAPTDL 172
            .|        |:....||..||.     ..|:|.::               |......|||.:..
Zfish    78 LP--------PEHHPPPQVSPPQNTVNVAATNATQQ---------------PGGSGGGGVAGSGG 119

  Fly   173 SYRRLAELMNQDYVHSLSVHARLQHMAAAGRMHEDQANPGMAQLQEPTPPQAHSSPAKSGSHSPM 237
            :.:      :.....|::.:..|          ..|..|.|.:.::.| .|.:|||:.|.:::
Zfish   120 TSK------SSSKSSSMATNPTL----------TKQIFPWMKESRQNT-KQKNSSPSASSANA-- 165

  Fly   238 EPALDVGMDEDFECSGDSCSDISLTMSPRNYNGEMDKSRNGAYTNSDSEDCSDDEGAQSRHEGGG 302
                        |.||
Zfish   166 ------------ESSG------------------------------------------------- 169

  Fly   303 MGGKDSQGNGSSSNSKSRRRRTAFTSEQLLELEREFHAKKYLSLTERSQIATSLKLSEVQVKIWF 367
             |.|...|:.:     |:|.|||:||.||:|||:|||..:||....|.::|..|.|||.|:||||
Zfish   170 -GEKSPPGSAA-----SKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLSERQIKIWF 228

  Fly   368 QNRRAKWKRVKAGLTSHGLGRNGTTSGTKIVVPIPV---------------------------HV 405
            ||||.|:|:.:   .|.|:|.:..........|:|:                           |.
Zfish   229 QNRRMKYKKDQ---KSKGIGSSSGGPSPTGSPPLPMQSSAGFMNSMHSMGSYDAPSPPSFNKPHQ 290

  Fly   406 NRFAVRSQHQQLEKMCLSGPK-----PDLRKKLSAEAIGGFEKFSGSTNASSPSGGPVGLG 461
            |.:|:.:.:|...|.|....|     ||....       |.:..||:....:..|.||.:|
Zfish   291 NAYAMSTAYQNPMKGCPPQQKYGNTPPDYDPH-------GLQGNSGNYGTPNMQGSPVYVG 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unpg	NP_477146.1	Homeobox	324..375	CDD:278475	30/50 (60%)
hoxb3a	NP_571192.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..135		22/123 (18%)
		Antp-type hexapeptide	140..145		1/4 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	147..184		14/106 (13%)
		Homeobox	184..236	CDD:278475	31/51 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	237..290		5/55 (9%)
		DUF4074	353..415	CDD:290032
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	381..417
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.900