DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment unpg and pitx2

DIOPT Version :9

Sequence 1:	NP_477146.1	Gene:	unpg / 35942	FlyBaseID:	FBgn0015561	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_571050.1	Gene:	pitx2 / 30164	ZFINID:	ZDB-GENE-990714-27	Length:	314	Species:	Danio rerio

Alignment Length:	287	Identity:	68/287 - (23%)
Similarity:	108/287 - (37%)	Gaps:	74/287 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 MAQLQEP--TPPQAHSSPAKSGSHSPMEPA-----LDVGMDEDFECSGDSCSDISLTMSPRNYNG 270
            |..:::|  .....|:.......|:|:..|     |...:|........:.||   |.||.:...
Zfish     1 MTSMKDPLSLDHHHHNHHVTGSKHAPLSMASSLQPLQRSVDSKHRLDVHTVSD---TSSPESVEK 62

  Fly   271 EMDKSRNGAYTNSDSEDCSDDEGAQSRHEGGGMGGKDSQGNGSSSNSKSRRRRTAFTSEQLLELE 335
            |..:|:|        ||.:||                     .|...:.||:||.|||:||.|||
Zfish    63 EKGQSKN--------EDSNDD---------------------PSKKKRQRRQRTHFTSQQLQELE 98

  Fly   336 REFHAKKYLSLTERSQIATSLKLSEVQVKIWFQNRRAKWKR----VKAGLTSHGLG--------- 387
            ..|...:|..::.|.:||....|:|.:|::||:||||||::    .:|.|..:|.|
Zfish    99 ATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERNQQAELCKNGFGPQFNGLMQP 163

  Fly   388 --------------RNGTTSGTKIVVPIP----VHVNRFAVR---SQHQQLEKMCLSGPK-PDLR 430
                          ..|.||.:......|    ::||..:.:   |....:..|.:|... |...
Zfish   164 YDDMYPSYTYNNWAAKGLTSASLSTKSFPFFNSMNVNPLSSQTMFSPPNSISSMSMSSSMVPSAV 228

  Fly   431 KKLSAEAIGGFEKFSGSTNASSPSGGP 457
            ..:...::......:..:|.|..||.|
Zfish   229 TGVPGSSLNSLNNLNNLSNPSLNSGVP 255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unpg	NP_477146.1	Homeobox	324..375	CDD:278475	24/50 (48%)
pitx2	NP_571050.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..93		28/123 (23%)
		Homeobox	86..138	CDD:278475	25/51 (49%)
		OAR	272..289	CDD:281777
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	276..289
		Nuclear localization signal. /evidence=ECO:0000255	282..286
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910