DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment unpg and Pdx1

DIOPT Version :9

Sequence 1:	NP_477146.1	Gene:	unpg / 35942	FlyBaseID:	FBgn0015561	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_074043.4	Gene:	Pdx1 / 29535	RGDID:	62387	Length:	283	Species:	Rattus norvegicus

Alignment Length:	336	Identity:	85/336 - (25%)
Similarity:	123/336 - (36%)	Gaps:	126/336 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 YFAQNHERLTHLIAGGCYLPSSPAGHPAAQQPQAQAQP--------QPPPPHPPTHA-----LEK 143
            |:|     .|.|....|.....|.       |:..|.|        |||||.||..|     ||:
  Rat     7 YYA-----ATQLYKDPCAFQRGPV-------PEFSANPPACLYMGRQPPPPPPPQFAGSLGTLEQ 59

  Fly   144 QLPPTLPHPLDTRFLPFNPAAAGVAPTDLSYRRLAELMNQDYVHSLSVHARLQHMAAAGRMHEDQ 208
            ..||.: .|.:...|..:||.|                   ::|        .|:
  Rat    60 GSPPDI-SPYEVPPLADDPAGA-------------------HLH--------HHL---------- 86

  Fly   209 ANPGMAQLQEPTPPQAHSSPAKSGSHSPMEPALDVGMDEDFECSGDSCSDISLTMSPRNYNGEMD 273
              |....|..|.|     .|..:|:.:.       |::|.        |.:.|...      .|.
  Rat    87 --PAQLGLAHPPP-----GPFPNGTETG-------GLEEP--------SRVHLPFP------WMK 123

  Fly   274 KSRNGAYTNSDSEDCSDDEGAQSRHEGGGMGGKDSQGNGSSSNSKSRRRRTAFTSEQLLELEREF 338
            .::..|:              :|:..||....:..:         ::|.|||:|..||||||:||
  Rat   124 STKAHAW--------------KSQWAGGAYAAEPEE---------NKRTRTAYTRAQLLELEKEF 165

  Fly   339 HAKKYLSLTERSQIATSLKLSEVQVKIWFQNRRAKWKRVK-----AGLTSHGLGRN------GTT 392
            ...||:|...|.::|..|.|:|..:||||||||.|||:.:     :|.||.|.|..      ..|
  Rat   166 LFNKYISRPRRVELAVMLNLTERHIKIWFQNRRMKWKKEEDKKRSSGTTSGGGGGEEPEQDCAVT 230

  Fly   393 SGTKIV-VPIP 402
            ||.::: :|.|
  Rat   231 SGEELLALPPP 241

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unpg	NP_477146.1	Homeobox	324..375	CDD:278475	28/50 (56%)
Pdx1	NP_074043.4	Transactivation domain	13..73		19/67 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	36..81		17/64 (27%)
		Antp-type hexapeptide	118..123		0/10 (0%)
		Homeobox	149..203	CDD:395001	30/53 (57%)
		Nuclear localization signal. /evidence=ECO:0000250	197..203		4/5 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..283		12/41 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810