DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment unpg and Gbx1

DIOPT Version :9

Sequence 1:	NP_477146.1	Gene:	unpg / 35942	FlyBaseID:	FBgn0015561	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_056554.1	Gene:	Gbx1 / 231044	MGIID:	95667	Length:	418	Species:	Mus musculus

Alignment Length:	455	Identity:	164/455 - (36%)
Similarity:	198/455 - (43%)	Gaps:	111/455 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 TPATATPPSPPEERDQE------QEAEQEQELS--ARAMVASSALGLTQFPLYNPWLHGYFAQNH 97
            ||.....|.||.||:..      .|....:.|.  ||:....||.|..:.|       |...|.
Mouse     7 TPNPPARPLPPYERESAAPEPHCAEPAPRRHLGPRARSEPCVSARGARRGP-------GSAMQR- 63

  Fly    98 ERLTHLIAGGCYLPSSPAGHPAAQQPQAQAQP-----QPPPPHPPTHALEKQLPPTLPH-PLDTR 156
                  .|||    .:|.|...:......|..     .||||. ..|.|....|..:|: ||
Mouse    64 ------AAGG----GAPGGSGGSSGGPGAAFSIDSLIGPPPPR-SGHLLYTGYPMFMPYRPL--- 114

  Fly   157 FLPFNPAAAGVAPTDLSYRRLAELMNQDYVHSLSVHARLQHMAAAGRMHEDQANPGMAQL----- 216
               ..|.|...||.......||.|        .|...||.:...||.   .||.|.|..|
Mouse   115 ---VLPQALAPAPLPAGLPPLAPL--------ASFAGRLSNTFCAGL---GQAVPSMVALTTALP 165

  Fly   217 --QEPT-----PPQAHSSPAKSGSHSPMEPA---LDVGMD-EDFECSGDSCSD------------ 258
              .||.     ||:..::.|.:.|.|..|||   .|..:| |:...:.:..::
Mouse   166 SFAEPPDAYYGPPELAAAAASTASRSNPEPAARRTDGALDAEELLPAREKVTEPPPPPPPHFSET 230

  Fly   259 -ISLTMSPRNYNGEMDKSRNGAYTNSDSEDCSDDEGAQSR-----HEGGGMGG--------KDSQ 309
             .||....:.|:.:.:|....|...:.||...:..|..|.     ...||.|.        |.|.
Mouse   231 FPSLPAEGKVYSSDEEKLEPPAGDPAGSEQEEEGSGGDSEDSFLDSSAGGPGALLGPKPKLKGSP 295

  Fly   310 GNGSSSNS-----------KSRRRRTAFTSEQLLELEREFHAKKYLSLTERSQIATSLKLSEVQV 363
            |.|:...:           ||||||||||||||||||:|||.|||||||||||||.:||||||||
Mouse   296 GTGAEEGTPVATGVTTPGGKSRRRRTAFTSEQLLELEKEFHCKKYLSLTERSQIAHALKLSEVQV 360

  Fly   364 KIWFQNRRAKWKRVKAGLTSHGLGRNG-TTSGTKIVVPIPVHVNRFAVRSQHQQLEKMCLSGPKP 427
            |||||||||||||:|||..|   .|:| .....|||||||||||||||||||||:|:    |.:|
Mouse   361 KIWFQNRRAKWKRIKAGNVS---SRSGEPVRNPKIVVPIPVHVNRFAVRSQHQQMEQ----GARP 418

Fly 428 427
Mouse 419 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unpg	NP_477146.1	Homeobox	324..375	CDD:278475	46/50 (92%)
Gbx1	NP_056554.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..90		23/100 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	214..320		20/105 (19%)
		Homeobox	319..372	CDD:278475	48/52 (92%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850485
Domainoid	1	1.000	108	1.000	Domainoid score	I6437
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	176	1.000	Inparanoid score	I4042
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003648
OrthoInspector	1	1.000	-	-		otm44151
orthoMCL	1	0.900	-	-		OOG6_106620
Panther	1	1.100	-	-	LDO	PTHR24334
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4817
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.780