DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment unpg and DLX2

DIOPT Version :9

Sequence 1:	NP_477146.1	Gene:	unpg / 35942	FlyBaseID:	FBgn0015561	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_004396.1	Gene:	DLX2 / 1746	HGNCID:	2915	Length:	328	Species:	Homo sapiens

Alignment Length:	320	Identity:	85/320 - (26%)
Similarity:	114/320 - (35%)	Gaps:	100/320 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   204 MHEDQANPGMAQLQEPTPPQ------AHSSPAKSGSHSPME-PALDVGMDED------------- 248
            ||..|........|...||.      ..:|.:.|..|.|.| |.|.|....|
Human    12 MHSTQIAASSTYHQHQQPPSGGGAGPGGNSSSSSSLHKPQESPTLPVSTATDSSYYTNQQHPAGG 76

  Fly   249 ---------------FECSGDSCSDISLTMSPRNYNGEMDKSRNGAYTN------SDSEDCSDDE 292
                           ::.||       |...|.:.....|.....|||:      |.|...::.|
Human    77 GGGGGSPYAHMGSYQYQASG-------LNNVPYSAKSSYDLGYTAAYTSYAPYGTSSSPANNEPE 134

  Fly   293 GAQSRHEGGGMGGKDSQGNGSSSNSKSRRRRTAFTSEQLLELEREFHAKKYLSLTERSQIATSLK 357
            ......|...:.||.         .|.|:.||.::|.||..|:|.|...:||:|.||:::|.||.
Human   135 KEDLEPEIRIVNGKP---------KKVRKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLG 190

  Fly   358 LSEVQVKIWFQNRRAKWKRV-KAGLTSHGLGRNGTTSGTKIVVPIPVHVNRFAVRSQHQQLEKMC 421
            |::.||||||||||:|:|:: |:|                 .:|...|....|        ...|
Human   191 LTQTQVKIWFQNRRSKFKKMWKSG-----------------EIPSEQHPGASA--------SPPC 230

  Fly   422 LSGPKPDLRKKLSAEAIGGFEKFSGSTNASSPSGGPVGLGVGVGVGVGVGLGVSTPLSLA 481
            .|.|       :||.|...|    |.....:..|||     |.| |.|.|...|:|.|.|
Human   231 ASPP-------VSAPASWDF----GVPQRMAGGGGP-----GSG-GSGAGSSGSSPSSAA 273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unpg	NP_477146.1	Homeobox	324..375	CDD:278475	27/50 (54%)
DLX2	NP_004396.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	16..81		13/64 (20%)
		DLL_N	51..132	CDD:289198	15/87 (17%)
		Homeobox	155..208	CDD:278475	28/52 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	211..270		22/100 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	300..328
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910