DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment unpg and GSX2

DIOPT Version :9

Sequence 1:	NP_477146.1	Gene:	unpg / 35942	FlyBaseID:	FBgn0015561	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_573574.2	Gene:	GSX2 / 170825	HGNCID:	24959	Length:	304	Species:	Homo sapiens

Alignment Length:	312	Identity:	91/312 - (29%)
Similarity:	116/312 - (37%)	Gaps:	92/312 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 AQPQP--PPPHP-PTHALEKQLPPTLPHPLDTRFLPFNPAAA-GVAPTDLSYRRLAELMNQDYVH 187
            ::|.|  |.||| |...:...:||.|...:.....|...:.| .|.|          |....::|
Human    16 SRPAPSLPEPHPGPDFFIPLGMPPPLVMSVSGPGCPSRKSGAFCVCP----------LCVTSHLH 70

  Fly   188 SL--SVHARLQH-------------MAAAGRM----HEDQANPGMAQL--------QEPTPPQAH 225
            |.  ||.|....             ..|||.:    .:..:.||.||.        ....|||.|
Human    71 SSRGSVGAGSGGAGAGVTGAGGSGVAGAAGALPLLKGQFSSAPGDAQFCPRVNHAHHHHHPPQHH 135

  Fly   226 SSPAKSGSHSPMEPALDVGMDEDFECSGDSCSDISLTMSPRN---------YNGEMDKSRNGAYT 281
            ..     .|.|.:|    |.......:..:.:..:....|::         || ..|..|....|
Human   136 HH-----HHQPQQP----GSAAAAAAAAAAAAAAAALGHPQHHAPVCTATTYN-VADPRRFHCLT 190

  Fly   282 NSDSEDCSDDEGAQSRHEGGGMGGKDSQGNGSSSNSKSRRRRTAFTSEQLLELEREFHAKKYLSL 346
                                 |||.|     :|.....:|.||||||.|||||||||.:..|||.
Human   191 ---------------------MGGSD-----ASQVPNGKRMRTAFTSTQLLELEREFSSNMYLSR 229

  Fly   347 TERSQIATSLKLSEVQVKIWFQNRRAKWKRVKAGLTSHGLGRNGTTSGTKIV 398
            ..|.:|||.|.|||.||||||||||.|.|:     ...|..|| :.:|.|.|
Human   230 LRRIEIATYLNLSEKQVKIWFQNRRVKHKK-----EGKGTQRN-SHAGCKCV 275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unpg	NP_477146.1	Homeobox	324..375	CDD:278475	36/50 (72%)
GSX2	NP_573574.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	116..151		10/43 (23%)
		Homeobox	206..258	CDD:306543	37/51 (73%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	283..304
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810