DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment unpg and AgaP_AGAP006923

DIOPT Version :9

Sequence 1:	NP_477146.1	Gene:	unpg / 35942	FlyBaseID:	FBgn0015561	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	XP_308835.4	Gene:	AgaP_AGAP006923 / 1270160	VectorBaseID:	AGAP006923	Length:	580	Species:	Anopheles gambiae

Alignment Length:	628	Identity:	230/628 - (36%)
Similarity:	288/628 - (45%)	Gaps:	203/628 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MERPALLQNGEIGTMESPTTRLA-SKPFP-KPFSIESLIA-----------------------NQ 40
            |::.:.:|...:|::....|.:. |:|.| ..||||:|||                       :.
Mosquito     1 MDKLSTVQPAPVGSVVCGVTDVKFSRPLPSSSFSIENLIAVKRRRSAGAGSSSPEIDPGDHHGSC 65

  Fly    41 TPATATPPSPP-------EERDQEQEAEQEQELSARAMVASSA--LGLTQF-PLYNPWLHG---- 91
            :|..|.|..||       |...|:|:..|:..|:|.|....||  |..:.| |||:||..|
Mosquito    66 SPPAAGPNVPPGYGGLLLETSQQQQQQHQQHYLAAAAAAGYSAAMLSFSSFPPLYHPWSTGLPTA 130

  Fly    92 --YFAQ-NHERLT-----HLIAGGCYLPSSPAG-------HPAAQQPQAQAQPQPPPPHPPTHAL 141
              |.:| .:|:|:     |..:||  ..|.|.|       :|||:||.......|..|..|..|.
Mosquito   131 GRYLSQAANEKLSSFLFHHHSSGG--NKSHPGGIEPCPGTYPAAEQPSGGGGVLPTRPSSPRGAR 193

  Fly   142 EKQLPPTLPHPLDTRFLPFNPAAAGVAPTDLSYRRLAELMNQDYVHSLSVHARLQHMAAAGRMHE 206
            ..          |..|           ||::      :|:::.|    :|:            |.
Mosquito   194 SG----------DKLF-----------PTEV------DLLSKVY----AVY------------HH 215

  Fly   207 DQANPGMAQLQEP---TPPQAHSSPAKSGS-----------------HSPMEP--ALDVGMD--- 246
            .|......|.|:|   ||....:....:|:                 |.|..|  .:|.|.|
Mosquito   216 QQQQQQQQQQQQPRYLTPSSPGTGYTTTGAALEPNGVNPGTGNGQLHHQPQSPGETIDPGSDGGP 280

  Fly   247 ED-------FECSGDSC------SDISLTMSPRNYNGEMDKSRNGAYTNSDSEDCSDDEGAQSRH 298
            ||       .|..|:|.      .|||||:||.......|..      :|||:.||:|:..|: .
Mosquito   281 EDEERTRPTIEDGGESADGSAYSDDISLTLSPSGCGKTTDLG------DSDSDACSEDDCTQN-S 338

  Fly   299 EGGGMGGKDSQGNGSSSNSKSRRRRTAFTSEQLLELEREFHAKKYLSLTERSQIATSLKLSEVQV 363
            ...|..||...|   :.||||||||||||||||||||||||||||||||||||||||||||||||
Mosquito   339 SSSGRAGKSGSG---AENSKSRRRRTAFTSEQLLELEREFHAKKYLSLTERSQIATSLKLSEVQV 400

  Fly   364 KIWFQNRRAKWKRVKAGLTSHGLG-RNGTTSGT-------KIVVPIPVHVNRFAVRSQHQQLEKM 420
            ||||||||||||||||||.||||| ||.:.|||       ||||||||||||||:||||||:|||
Mosquito   401 KIWFQNRRAKWKRVKAGLNSHGLGNRNASGSGTGTTGTANKIVVPIPVHVNRFAIRSQHQQMEKM 465

  Fly   421 CLSGPKPDLRK-KLSAEAIGGFEKF----------------------------------SGSTNA 450
            .|.|||.:||| .|.....||||:|                                  |.|:..
Mosquito   466 NLVGPKAELRKADLGLAESGGFERFGLNKHLSKVVPSAEVTGNRVDPAFQAAPAPSEGASKSSIE 530

  Fly   451 SSPSGGPVGLG---VGVGVGVGVGLGV----------STPLSL 480
            ||.:||..|.|   .|:|||..:|:||          |.|::|
Mosquito   531 SSGTGGGGGGGAGTAGIGVGFQLGMGVCSLAAPPHSASHPVAL 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unpg	NP_477146.1	Homeobox	324..375	CDD:278475	50/50 (100%)
AgaP_AGAP006923	XP_308835.4	Homeobox	359..412	CDD:278475	52/52 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	115	1.000	Domainoid score	I11801
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	255	1.000	Inparanoid score	I5555
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D858478at2759
OrthoFinder	1	1.000	-	-		FOG0003648
OrthoInspector	1	1.000	-	-		oto110902
Panther	1	1.100	-	-	LDO	PTHR24334
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X14
TreeFam	1	0.960	-	-
	11	10.930