DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rab32 and Rasef

DIOPT Version :9

Sequence 1:	NP_525109.1	Gene:	Rab32 / 35940	FlyBaseID:	FBgn0002567	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_001264263.1	Gene:	Rasef / 298138	RGDID:	1306418	Length:	709	Species:	Rattus norvegicus

Alignment Length:	783	Identity:	176/783 - (22%)
Similarity:	287/783 - (36%)	Gaps:	202/783 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 EGDGDPKDESEEATAKIKGRSRFTAALRSLSKT-KTKRERELDKSTDRETRSAEEEAQETPGELE 92
            |.|.||::               .|.|||:..| .|.....|:::   |.|:...|......|.|
  Rat     2 EADADPEE---------------LARLRSVFTTYDTNCSGRLERA---EFRTLCAELHVAEAEAE 48

  Fly    93 DVASSISTD--------------SGALGKTKKKSLTRRLLLGGLRKSGKTPKGRP-HS------- 135
            .|...:.||              .||||:...::   :.|...:......|..|. |:
  Rat    49 AVFLGLDTDRDGAITFPEFARGFRGALGQDSGEA---QGLWDAVEPESPGPAWRDFHTRLGEEAQ 110

  Fly   136 -LATSDDISV----------------EH----------LETTPLPSPPGSPTSAGSSTLQITISG 173
             :...:.:|.                ||          |::|.:.:              :.|:.
  Rat   111 LIPRKEQVSTLYQNINLVEPRLIQPYEHVIRNFLREIRLQSTEMEN--------------LAIAV 161

  Fly   174 KKVEPSPAKKSGKSRPKSDTDYLTPAAEERKPRKKTTTTTVTTRDTSSSTRTTKLLVSKKKPQSP 238
            |:.:...|.:..:...:.|........|.||..|:.....:|.......|....|.|:.|:.:..
  Rat   162 KRAQDKAAIQLSELEEEMDQRIQAVENETRKDEKRKAEEALTDLRRQYETEVGDLQVTIKRLKKL 226

  Fly   239 ERESPSASPSPLIT---------TTESTR-------------------DTPPRERAPAKPSRVQS 275
            |.:|...|....:|         |||:.:                   |....:.|   ...:.|
  Rat   227 EEQSRKISQKQDVTSLKKQIYDLTTENQKLKKDLLETQTNLAFLQSELDALKSDYA---DQTMNS 288

  Fly   276 ASGTGAVRK-SQSSSASSRKLELMQQQQQRGHRLNARPLAELANTEPQ----------------P 323
            ......:|: ::..|...|::|::|...::.|..|....:.|.||..:                .
  Rat   289 ERDLELIREFNEDRSNLERQIEVLQTANRKLHDSNDGLRSALENTYSKLTKSLRMNNISPGNTIS 353

  Fly   324 SGQQSLDPSTSPPAAEDGVSSAESAQ------TIANPPPVVRFEVGSAVRSPLSAYEAALAAAAS 382
            |.....:..:|.|...|..|.:..|.      .:.:|...:.:||.|.   |.|.:::.|    |
  Rat   354 SSSPKFNHHSSQPLGYDRSSHSSYADEDCDCLALCDPLQKMNYEVDSL---PESCFDSGL----S 411

  Fly   383 QQPNSNEELSDSSIRRLSFAQQQLILGDH---DSIEG-----------RRETLHYQSVASEYSNQ 433
            ...:|||  .||.:   .:..|:.....|   :|:||           ..||...:||||.....
  Rat   412 TLRDSNE--CDSEV---DYKPQEGFQSLHRTEESLEGDTSDTDVPDMRDEETFDCESVASVLHGH 471

  Fly   434 DSGSEDDSEEQADTTEPENAKPMPAFGDLTMDQEMEPAIMTSTSDKREHLYKILVIGELGTGKTS 498
            ..||..:.     :|...:.|.:.|   |:.:.:|....:.|||.|   .|||::.|:...||:|
  Rat   472 PQGSAGEG-----STVSSSRKTISA---LSPETDMVNNTLKSTSQK---AYKIVLAGDAAVGKSS 525

  Fly   499 FIKRYVHQFFSQNYRATIGVDFALKVLQWDANTIVRLQLWDIAGQERFGNMTRVYYKEAVGAFIV 563
            |:.|.....|..|..||:||||.:|.|..|....| |||||.||||||.::.:.|:::|.|..::
  Rat   526 FLMRLCKNEFQGNTSATLGVDFQMKTLMVDGEPTV-LQLWDTAGQERFRSIAKSYFRKADGVLLL 589

  Fly   564 FDVTRSGTFDCVSKWKEDLDSKVQLPDGS--PIPCILLANKCD------QEKQGIITQPEKMDEY 620
            :|||...:|..|.:|      ...:.||:  .:|.:|:.||.|      .|.|..|:  ..:.|.
  Rat   590 YDVTCEKSFLNVREW------VAMVEDGTHRSVPIMLVGNKADLRDAATAENQKCIS--SHLGEK 646

  Fly   621 VRENGFAGWFETSAKENINIDEAARALVNKILINDKLISADLADGDKFNLSAADATGSDA---KN 682
            :.....|.:.|||||:..|:.||...|..::....:      .|..|...|.|.:|...:   ||
  Rat   647 LAMTYGALFCETSAKDGSNVVEAVLHLAREVKKRAE------NDDSKSITSLATSTSRKSLQMKN 705

  Fly   683 KCS 685
            .|:
  Rat   706 CCN 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab32	NP_525109.1	Rab32_Rab38	484..686	CDD:206692	70/213 (33%)
Rab32	NP_525109.1	RAB	484..652	CDD:197555	62/175 (35%)
Rasef	NP_001264263.1	EFh	12..72	CDD:238008	14/62 (23%)
		EF-hand_7	13..71	CDD:290234	14/60 (23%)
		RILP-like	<191..268	CDD:304877	15/76 (20%)
		BBP1_C	192..381	CDD:291921	33/191 (17%)
		RAB	511..680	CDD:197555	62/177 (35%)
		Rab	511..675	CDD:206640	62/172 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I4870
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.960