Protein Alignment Rab32 and RAB32

DIOPT Version :10

• Sequence 1: NP_525109.1
• Gene: Rab32 / 35940
• FlyBaseID: FBgn0002567
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_006825.1
• Gene: RAB32 / 10981
• HGNCID: 9772
• Length: 225
• Species: Homo sapiens
• Alignment Length: 227
• Identity: 146/227 - (64%)
• Similarity: 171/227 - (75%)
• Gaps: 9/227 - (3%)

  Fly   460 GDLTMDQEMEPAIMTSTSDKREHLYKILVIGELGTGKTSFIKRYVHQFFSQNYRATIGVDFALKV 524
            ||..:.....||     .:.||||:|:|||||||.||||.|||||||.|||:|||||||||||||
Human     7 GDPGLGAAAAPA-----PETREHLFKVLVIGELGVGKTSIIKRYVHQLFSQHYRATIGVDFALKV 66

  Fly   525 LQWDANTIVRLQLWDIAGQERFGNMTRVYYKEAVGAFIVFDVTRSGTFDCVSKWKEDLDSKVQLP 589
            |.||:.|:|||||||||||||||||||||||||||||:|||::||.||:.|.|||.||||||.||
Human    67 LNWDSRTLVRLQLWDIAGQERFGNMTRVYYKEAVGAFVVFDISRSSTFEAVLKWKSDLDSKVHLP 131

  Fly   590 DGSPIPCILLANKCDQEKQGIITQPEKMDEYVRENGFAGWFETSAKENINIDEAARALVNKILIN 654
            :|||||.:||||||||.|.. ...|.::|::.:|:|||||||||||:||||:||||.||.|||:|
Human   132 NGSPIPAVLLANKCDQNKDS-SQSPSQVDQFCKEHGFAGWFETSAKDNINIEEAARFLVEKILVN 195

  Fly   655 DKLISADLADGDKFNLSAADATGSDAKNKCSC 686
            .:....:..|.||..|   |.....|:||..|
Human   196 HQSFPNEENDVDKIKL---DQETLRAENKSQC 224

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab32	NP_525109.1	PHA03247	<126..481	CDD:223021	4/20 (20%)
		Rab32_Rab38	484..686	CDD:206692	137/201 (68%)
RAB32	NP_006825.1	Rab32_Rab38	26..224	CDD:206692	137/201 (68%)
		Switch 1. /evidence=ECO:0000269|PubMed:24856514, ECO:0007744|PDB:4CYM, ECO:0007744|PDB:4CZ2	48..62		11/13 (85%)
		Switch 2. /evidence=ECO:0000269|PubMed:24856514, ECO:0007744|PDB:4CYM, ECO:0007744|PDB:4CZ2	84..97		12/12 (100%)
		PKA-RII subunit binding domain	178..197		14/18 (78%)