DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rme-8 and GRV2

DIOPT Version :9

Sequence 1:	NP_610467.1	Gene:	Rme-8 / 35939	FlyBaseID:	FBgn0015477	Length:	2408	Species:	Drosophila melanogaster
Sequence 2:	NP_180257.3	Gene:	GRV2 / 817230	AraportID:	AT2G26890	Length:	2554	Species:	Arabidopsis thaliana

Alignment Length:	2751	Identity:	731/2751 - (26%)
Similarity:	1192/2751 - (43%)	Gaps:	594/2751 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 FLVTKHSWKGRYKRILSIGTAGISTYNPDKLDLTNRWSY---SDIVAAAP-----SKTTNIPHDF 69
            :||.||||:|||||||.|.:.||.|.:|:.|.:||  ||   |:...|:|     ..|.::..:|
plant    26 YLVVKHSWRGRYKRILCISSGGIVTLDPNTLAVTN--SYDTGSNFDGASPLVGRDENTESVGGEF 88

  Fly    70 VITIKKD--KKLDTIKLSSEYRNDILSSILKYYKEFADKPKNAQRFSAYKYHWSGIS-------- 124
            .:.::.|  .|...:|.||..|..||:.:                   |:..|:.|.
plant    89 TVNVRTDGKGKFKAMKFSSRCRASILTEL-------------------YRLRWNQIRPVAEFQVL 134

  Fly   125 ---------LPTVLEVTPCSLDQLDPTTNDVLASYMYKDI-EGIIAGISDY-------EGGIVMA 172
                     :|..|::|...|:.:|..:.:......::|: ...|..:||.       ..|.|:.
plant   135 HLRRRNAEWVPYKLKITFVGLELVDSKSGNSRWILDFRDMGSPAIILLSDAYRTKSADSAGFVLC 199

  Fly   173 --YGGFSRLHLFKA---LNHHEIVQNIAQRSAQFLGIETKILKSQ-ITLEQFERQRFGKFSGDQF 231
              ||..|:  .|:|   ..:..||.::|:.:...:|:...:..|| :|:.::..:|..:..|.:
plant   200 PMYGRKSK--AFRAAPGTTNSSIVASLAKTAKSMVGVFLSVDDSQLLTVSEYMTRRAKEAVGAE- 261

  Fly   232 QTSSTEFSVHK-----------------ITPR-----HPDPVKRILCLTEVTLLERDPQTYSVCT 274
            :|.:..:||.:                 |.|:     |.|.|...|.||:.:|:||....|.|..
plant   262 ETPNGWWSVTRLRSAAHGTLNMPGLSLAIGPKGGLGEHGDAVALQLILTKASLVERRIDNYEVVI 326

  Fly   275 LRPLTDVFALVRDKDNLQRFSIEYKNGI-VRNYSTNDRDSLLATVLDAVRSSGNQDVHVRIGNTP 338
            :|||:.|.:|||..:..|.|:||:.:|. |..|::..||:|||.:||.:::.|:..:.|....|.
plant   327 VRPLSSVSSLVRFAEEPQMFAIEFSDGCPVLVYASISRDNLLAAILDTLQTEGHCPIPVLPRLTM 391

  Fly   339 RGKRYVPLNSSV-----------DEET-EANLMRL-------VINNFQNPSKRYEILER---FNA 381
            .|.|..|....|           |.|| ..:|..|       |......|..|..:..|   |||
plant   392 PGHRIDPPCGRVSLISGPQHLVADLETCSLHLKHLAAAAKDAVAEGGSVPGCRARLWRRIREFNA 456

  Fly   382 NVPHSGL--NYSVTQDSLFAENKDKLILSALQALAQKELDSPTAQLSNLELEA----IFHALTRL 440
            .:|::|:  |..|.:.:|.|      :::.|.:.....:|:|.....:.:..|    ....|.||
plant   457 CIPYTGVPANSEVPEVTLMA------LITMLPSTPNLPVDAPPLPPPSPKAAATVIGFVTCLRRL 515

  Fly   441 LASKVGYAAFTNLPGFREIIGTKVVAALRRKDLAVTYSAIDMINSLMHSVNSD----HDLKQEQ- 500
            |:|:   :|.:::..|...: .:::..||.....|...|..:|.||:...::|    .|.:.|:
plant   516 LSSR---SAASHIMSFPAAV-NRIMGLLRNGSEGVAAEAAGLIASLIGGWSADLSTAPDSRGEKH 576

  Fly   501 ----LNKSSILSSKSFLETLLN-MWTTHVSHGSGALVLSAMLDFMTFALCVPYSETTDGKQFDTL 560
                ..||.:.:.:.::..|:| :....||    .|...|:::.....:|.|:.|||....|..|
plant   577 ATIMHTKSVLFAQQGYVTILVNRLKPMSVS----PLFSMAIVEVFEAMVCDPHGETTQYTVFVEL 637

  Fly   561 LELVADRGRYLYKLFQHPSLAIVKGAGLVLRAIIEEGELQVAQQMQALALDEAALCRHLLVALYT 625
            |..:|...|.|:.||.||:.::.:...:::|.|.||..: .|:.|:..||.:.||.||||.|...
plant   638 LRQIAALRRRLFALFAHPAESVRETIAVIMRTIAEEDAI-AAESMRDAALRDGALLRHLLNAFSL 701

  Fly   626 PSNDPTQTTQRQLSRHLIGLWLTDSEEAMELFKRIFPAGLLTFLES--EETVPESDVEEDKLNFR 688
            |:::     :|::||.|:.||....:.|::|..|:.|.||:.:|.:  ::.|.::|.|....|.|
plant   702 PASE-----RREVSRQLVALWADSYQPALDLLSRVLPPGLVAYLHTRPDDVVDDTDQEGSSTNRR 761

  Fly   689 DNLKFAIQHSNKTRKNVIEKHL--QGIKHWGMNLIEKQDGAAQALKNRPV--------------- 736
            .  |..:|.    |:..|.|.:  |.|.....|.:|..|.|.....|..|
plant   762 Q--KRLLQQ----RRGRIAKGMGAQDIPLPPGNNVEAGDAAKHMSANASVPDNFQRRAADSSSEA 820

  Fly   737 -----------------VLRN---------------RRQKKKTSDVV------------------ 751
                             |.:|               .:.:...||||
plant   821 SNPQASAFPGVDSTIAGVSQNGYPAFASVTTNANGHEQPETNASDVVGSDPNLYGIQNSVLPAPA 885

  Fly   752 ---------------VNLPFFFYSFAKDHSLPNLIWNHKTREEL---------RMCLENELRQFL 792
                           :|...|:.:|..||:..:||||.:||:||         .:.:|.|..:.:
plant   886 QVIVESTAVGSGKLLLNWREFWRAFGLDHNRADLIWNERTRQELIEALKAEVHNLDVEKERTEDI 950

  Fly   793 NDRDL---AGQMI---VAWNYQEFEVAYQCLADEIKIGDYYIRLILEK------DDWPQNLVKDP 845
            :..|:   .||.|   ::|||.||.|:|:.|:.|:.:|.||:||:||.      .|:|   ::||
plant   951 SPGDVEATTGQEIIPRISWNYSEFSVSYRSLSKEVCVGQYYLRLLLESGNAGKAQDFP---LRDP 1012

  Fly   846 IELFNALYRRVLCRQRVNDDQMTV---------------------------------FSLQALAK 877
            :..|.|||.|..|..   |..:|:                                 ...:|:|.
plant  1013 VAFFRALYHRFQCDA---DMGLTIDGAVPDELGSSGDWCDMSRLDGFGGGGGASVRELCARAMAI 1074

  Fly   878 VYRRYHAEIGKFNDMSYILQLSDRCLSPSMRDALINLISCLVLEKSNSRALIDHVQCL--VDLIT 940
            ||.:::..||.|...::|..|.||....::|..|:.|:..||....|....:....|:  |||:|
plant  1075 VYEQHYNTIGPFEGTAHITALIDRTNDRALRHRLLLLLKALVKVLLNVEGCVVVGGCVLAVDLLT 1139

  Fly   941 LAHLHKGRAQLNTKTNVIEAGPNMGTYEEKDWYYNIEKDGQKPERQGPITYSELKELWQKGLITP 1005
            :.|.:..|..:..::|:|.|...|  ...|:|.| |:|.|.:   .||:....::.||.|..|..
plant  1140 VVHENSERTPIPLQSNLIAATAFM--EPPKEWMY-IDKGGAE---VGPVEKDVIRSLWSKKDIDW 1198

  Fly  1006 KTRCWAIGMDGWRSLQQIPQLKWCLIAKGTPLYDETELSSKILDILIKCTSFFPSRTQNGVAVLI 1070
            .|:|.|:||..|:.|:.|.:|:|. :|...|:...:::....|.||....|........| .::.
plant  1199 TTKCRALGMSDWKKLRDIRELRWA-VAVRVPVLTPSQVGDAALSILHSMVSAHSDLDDAG-EIVT 1261

  Fly  1071 PGPKLSRKLSEFICLPHVVQVCLTHDPGLLERVATLLYQIMEDNPE-MPKVYLTGVFYFMLMYTG 1134
            |.|::.|.||...||||:.|..|:.:|.::|..|.||..::..|.: |.::|.||.|||.|.|.|
plant  1262 PTPRVKRILSSTRCLPHIAQALLSGEPVIVEAGAALLKDVVTRNSKAMIRLYSTGAFYFALAYPG 1326

  Fly  1135 SNILPITRFLKMTHMKQGFRSEE----TSQSGIMHRSILGQLLPEAMVCFLENYSAEKFAEIFLG 1195
            ||:..|.:...:||:.|.|...|    :|...:..||:||.||||:::..||......||...:.
plant  1327 SNLYSIAQLFSVTHVHQAFHGGEEATVSSSLPLAKRSVLGGLLPESLLYVLERSGPAAFAAGMVS 1391

  Fly  1196 EFDTPEVIWSSEMR-RLLIEKIAAHIADFTPRLRGHTMARYPYLAIPVISYPQLENELFCHIYYL 1259
            :.||||:||:.:|| ..||.::..|:.|:..:|..|..:.|.|..:|.::||:|.:|::||.|||
plant  1392 DSDTPEIIWTHKMRAENLICQVLQHLGDYPQKLSQHCHSLYDYAPMPPVTYPELRDEMWCHRYYL 1456

  Fly  1260 RHLCDTQKFPNWPISDPVQLLKHTLDAWRKEVEKKPPQMTIQQAYQDLGI--------DLTKTPK 1316
            |:|||..:||||||.:.|:.|:..|..||:|:.:||..::..:|.:.|.|        ||.:|..
plant  1457 RNLCDEIQFPNWPIVEHVEFLQSLLVMWREELTRKPMDLSEGEACKILEISLNNVSSDDLNRTAS 1521

  Fly  1317 P----------------DESMIRKSYYKLAQMYHPDKNPNGREIFEKVNQAYEFLCSRNVWSSGG 1365
            .                ||..:::.|.|||..|||||||.|||.|..|.:|||.| ...:....|
plant  1522 VELNEEISNISKQIQNLDEEKLKRQYRKLAMRYHPDKNPEGREKFLAVQKAYECL-QATMQGLQG 1585

  Fly  1366 PDPNNIVLILRTQSILFERYPDVLRPYKYAGYPQLIKTIRLETRDDELFSKE-AQLLTAASELCY 1429
            |.|..::|:|:.|.||:.||..||||:||||||.|:..:.::..|:...|.: :.||.|||||..
plant  1586 PQPWRLLLLLKAQCILYRRYGHVLRPFKYAGYPMLLDAVTVDKDDNNFLSNDRSPLLVAASELVS 1650

  Fly  1430 HTVHCSALNAEELRREEGIEALLEAYTRCVSILGVDSKPDSLHYQ----VISNVTRCFEVACNFE 1490
            .|...|:||.|||.|:.|::.|....:||:.::    :|.:..::    :::||.|...|...||
plant  1651 LTCAASSLNGEELVRDGGVQLLSTLLSRCMCVV----QPTTSQHEPAAIIVTNVMRTLSVISQFE 1711

  Fly  1491 KCKQKIIQLPQLLSDVCRVVYFKHTLSV--SLVTSLAANNY--DLQCQLSRNGVLWSLLLFIFEY 1551
            ..:...::||.|:.|:......:...:.  :.:.|:|..:.  :||..|.:.|.||.:|..:.:|
plant  1712 SARAGFLELPSLIEDIVHCTELERVPAAVDAALQSIAKVSVFPELQHGLLKAGALWYILPLLLQY 1776

  Fly  1552 DYTLDESGVDVSDKSNQQQLANNLAKMAVLGCIALAGYSMELRQKPVTGSETNSPAAKAPPVIKP 1616
            |.|.:||              |::....|       |.|:::
plant  1777 DSTAEES--------------NSVESHGV-------GVSIQI----------------------- 1797

  Fly  1617 KPSVSAASSSTYTQNAHNPLQSKQLAITSGKEKESDTSSGSSDTASSTPTESEQQQQLTKTRTSA 1681
                        .:|.| .||:.|..         ...:|.....|.||
plant  1798 ------------AKNEH-ALQASQAL---------SRLTGLCADESLTP---------------- 1824

  Fly  1682 IQQKYIVTGEAKNSLIKQVLDRLLTRYISNQLATVRDSDVLKLLTANTRNPYLIWDNGTRAQLKD 1746
                       .|:....||..|||..:::.|......|:|..|..|...|.:||::.||::|.:
plant  1825 -----------YNATAADVLKALLTPKLASLLKDEVAKDLLSKLNTNLETPEIIWNSATRSELLN 1878

  Fly  1747 FLEQQRTASAKETHEDIAQVSELVSSFEFDAHKDELQIGGIFIRIYNDMPTHPIAQPKLF---IM 1808
            |:::||.....:...|:..    ..||.:||...|:.:|.:::::|||.|...|::|:.|   ::
plant  1879 FVDEQRACQCPDGSYDLKN----AQSFSYDALSKEVFVGNVYLKVYNDQPDSEISEPESFCNALI 1939

  Fly  1809 DLLEYLKHAY-------QFLQYKKNPASTAAPVNATPKMGNDGILTPTLAPNHPQLQQASTGKSG 1866
            |.:..|.|..       |.|...:|.:      |.||:: ...:..|:|...|...|.:|.|
plant  1940 DFISSLVHTELPSVSEDQNLIEDRNSS------NDTPEL-QSSVAEPSLIEEHSDHQPSSEG--- 1994

  Fly  1867 TTFDEVLTAYNRSKSRKKLETDALTEQQLALQQ--SKY-DFSSDGKIELHITMVLKALIAVIKAN 1928
                        .|:.:....|.|.....|||.  :|| |.:|....:..:..:.:.....|.:.
plant  1995 ------------MKNEECFLIDHLQLGLTALQNLLTKYPDLASVFSSKERLLPLFECFSVAIASK 2047

  Fly  1929 AEVEIQCIGNFDMIFGFLASNIFPDNSTVKAVALEVVSLVSRNKECVSEVAACEILGNYLVAL-- 1991
            .::...|                          |.|:|.::....|:..:.:.   |:.|:.|
plant  2048 TDIPKLC--------------------------LNVLSRLTAYAPCLETMVSD---GSSLLLLLQ 2083

  Fly  1992 ---KDPELRASQVKVLETLSGLMNVQEMIKEAQAKGATIYLLDMFCNSRNP---QIREMCAGILA 2050
               ..|..|...:.||..|:   :..|:...|...|..:|:|::....:..   |.|...|.:|.
plant  2084 MLHSAPSFREGALHVLYALA---STPELAWAAAKHGGVVYILELLLPLQKEIPLQQRAAAASLLG 2145

  Fly  2051 KMTADRLSGPKVRITVSKFLPALFIDAMVESPATS-VQLFESIHEHPELIWNDTTRSNVCDAVAD 2114
            |:.|..:.||:|.||:.:|||...:..:.:.|..: |...|...|.|||:|.....:::...:|.
plant  2146 KLVAQPMHGPRVAITLVRFLPDGLVSIIRDGPGEAVVHALERTTETPELVWTPAMAASLSAQIAT 2210

  Fly  2115 TCQRFYQLQKANSRHVWKDPE--ILKDIVSNEIVVAGVYLRLFVSNPAWTLRKPKQFLSDLLDFV 2177
            .....|:.|:..|...|..||  ..:..:.:|..|.|:|:|.|:.:|.:.||.||:||..|||..
plant  2211 MASDIYREQQKGSVIEWDVPEQSAGQQEMRDEPQVGGIYVRRFLKDPKFPLRNPKRFLEGLLDQY 2275

  Fly  2178 VEQIGKSSSEQDVLD-----LSTTALVELLRSQPNLADDIPVLGHIPKLFNLLSVQ--------- 2228
            :..:..:..||..:|     |.:.|||.|||..|.|||.|..||::|||...::.:
plant  2276 LSAMAATHYEQHPVDPELPLLLSAALVSLLRVHPALADHIGHLGYVPKLVAAVAYEGRRETMSSG 2340

  Fly  2229 ---------------------PKNT---------LSVLHQLSLSEFCVSAISQTEC----VAP-L 2258
                                 |..|         |.|||||:.|..|..|::.|..    |.| |
plant  2341 EVKAEEIGSDGVNESTDPSSLPGQTPQERVRLSCLRVLHQLAASTTCAEAMAATSAGNAQVVPLL 2405

  Fly  2259 KKCMEHNRDCIEKACEALSRLF---KHQHDSLISQSLEVGLIPFLLGLLD----------SRLEF 2310
            .|.:......| .|.|.|.|:.   ....|:|::|.|:||||..||||||          |.:::
plant  2406 MKAIGWLGGSI-LALETLKRVVVAGNRARDALVAQGLKVGLIEVLLGLLDWRTGGRYGLSSHMKW 2469

  Fly  2311 VDNPSAV-KAQIVAALKGMTHNLNYGDRVTQILLKHPVWAEFKDQRHDLFIADTTIRGYLTGVNP 2374
            .::.::: :...|..|.|......:..:|.:||....||:.:|||:||||:...|...  .||
plant  2470 NESEASIGRVLAVEVLHGFATEGAHCSKVREILDASEVWSAYKDQKHDLFLPSNTQSA--AGV-- 2530

  Fly  2375 TAGYLTAGPAQSVEVLTSPPP 2395
             ||::..........||:|||
plant  2531 -AGFIENSSNSLTYALTAPPP 2550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rme-8	NP_610467.1	DUF4339	972..1020	CDD:290937	17/47 (36%)
		DnaJ	1304..1356	CDD:278647	26/75 (35%)
		HEAT repeat	2174..2200	CDD:293787	8/30 (27%)
		HEAT repeat	2212..2243	CDD:293787	14/69 (20%)
		HEAT repeat	2253..2282	CDD:293787	9/36 (25%)
		HEAT repeat	2291..2327	CDD:293787	14/46 (30%)
GRV2	NP_180257.3	DUF4339	1169..1213	CDD:290937	17/47 (36%)
GRV2	NP_180257.3	DnaJ	1527..1576	CDD:278647	21/48 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	321	1.000	Domainoid score	I278
eggNOG	1	0.900	-	-		E1_KOG1789
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13574
Inparanoid	1	1.050	819	1.000	Inparanoid score	I79
OMA	1	1.010	-	-		QHG53869
OrthoDB	1	1.010	-	-		D11434at2759
OrthoFinder	1	1.000	-	-		FOG0007583
OrthoInspector	1	1.000	-	-		oto3898
orthoMCL	1	0.900	-	-		OOG6_103669
Panther	1	1.100	-	-	LDO	PTHR36983
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5690
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840