DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rme-8 and CG10565

DIOPT Version :9

Sequence 1:	NP_610467.1	Gene:	Rme-8 / 35939	FlyBaseID:	FBgn0015477	Length:	2408	Species:	Drosophila melanogaster
Sequence 2:	NP_001246856.1	Gene:	CG10565 / 40332	FlyBaseID:	FBgn0037051	Length:	646	Species:	Drosophila melanogaster

Alignment Length:	676	Identity:	117/676 - (17%)
Similarity:	214/676 - (31%)	Gaps:	221/676 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1295 PPQMTIQQAYQDLGIDLTKTPKPDESMIRKSYYKLAQMYHPDK-NPNGREI------FEKVNQAY 1352
            |.:...|..|..||:...:. :..|..:|::|.::..::|||| ...|.|:      |..:.:||
  Fly    69 PKEWKDQDHYAVLGLGKLRY-EASEDDVRRAYRRMVLLHHPDKRKAKGEEVIQDDDYFTCITKAY 132

  Fly  1353 EFLCS---RNVWSSGGPDPNNIVLILRTQSILFERYPDVLRPY-----KYAGYPQLIKTIRLETR 1409
            |.|.:   |..:.|..|:.::   .|.:|:.:...|..|...:     :::..|.:....:::.:
  Fly   133 EILGTSKPRRSFDSVDPEFDD---SLPSQNDIDNDYFGVFNKFFTLNGRWSEKPHVPSFGQVDAK 194

  Fly  1410 DDELFSKEAQLLTAASELCYHTVH-------CSALNAEELRREEGIE----ALLEAYTRCVSILG 1463
            .:|:            |..|:..:       .|.|:.|:  :|:|.:    ..:|...|...|
  Fly   195 REEV------------ERFYNFWYDFKSWREFSYLDEED--KEKGQDRDERRWIEKENRAARI-- 243

  Fly  1464 VDSKPDSLHYQVISNVTRCFEVACNFEKCKQKIIQLPQLLSDVCRVVYFKHTLSVSLVTSLAANN 1528
             ..|.:.:     |.:....::|.|.:|                |:..||.........:..|..
  Fly   244 -KRKKEEM-----SRIRSLVDLAYNNDK----------------RIQRFKQEEKDRKAAAKRAKM 286

  Fly  1529 YDLQCQLSRNGVLWSLLLFIFEYDYTLDESGV--DVSDKSNQQQLANNLAKMAVLGCIALAGYSM 1591
            ...|.|.:             |.|..:.|:.:  :.::|:.|::
  Fly   287 DAAQAQKA-------------EADRAIREAALAKEKAEKAEQKR--------------------- 317

  Fly  1592 ELRQKPVTGSETNSPAAKAPPVIKPKPSVSAASSSTYTQNAHNPLQSKQLAITSGKEKESDT--- 1653
             :.|..:...:......|....::.|    ......|.:|     ...||....|.||..:|
  Fly   318 -IEQIRIEREQQKKLLKKERKTLRDK----VKDCKYYAKN-----DKDQLKHMEGTEKICETFNL 372

  Fly  1654 -----------SSGSSDTASSTPT---------ESEQQQQLTKTRTSA--------IQQKYIVTG 1690
                       |.|.....::..|         |...|.|..|..:||        :::..:.:.
  Fly   373 AELQALNKAMESKGRESFVAALQTAEQKIAAELEEINQTQAKKLASSAATPKGVKEVKKNELWSN 437

  Fly  1691 EAKNSLIK-------------QVLDRLLTRYISNQLATVRDSDVLKLLTA--NTRNPYLIWDNGT 1740
            |....|||             .|:...:.::..:....|...|||....|  ||        :.:
  Fly   438 ENVQLLIKAVNLFPAGTAQRWDVIATFINQHSPDNTVLVNARDVLNKAKALQNT--------DHS 494

  Fly  1741 RAQLKDFLEQQRTASAKETHEDIAQVSELVSSFE-FDAHKDELQIGGIFIRIYNDMPTHPIAQPK 1804
            ::.||........||.:::.:|:....::....| ..|.|:.|:..|:..:..|
  Fly   495 KSSLKTQANDAAFASFEKSKKDVQTCKDITLGEETAQASKENLKQNGVDHKANN----------- 548

  Fly  1805 LFIMDLLEYLKHAYQFLQYKKNPASTAAPVNATPKMGNDGILTPTLAPNHPQLQQASTGKSGTTF 1869
                             |..|...:..||.|            ||.||........|||....
  Fly   549 -----------------QSTKQNGTAPAPAN------------PTAAPAPVPATNGSTGGGAA-- 582

  Fly  1870 DEVLTAYNRSKSRKKLETDALTEQQL 1895
                     ||:..| |..||.||.:
  Fly   583 ---------SKTWTK-EEQALLEQAI 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rme-8	NP_610467.1	DUF4339	972..1020	CDD:290937
		DnaJ	1304..1356	CDD:278647	16/58 (28%)
		HEAT repeat	2174..2200	CDD:293787
		HEAT repeat	2212..2243	CDD:293787
		HEAT repeat	2253..2282	CDD:293787
		HEAT repeat	2291..2327	CDD:293787
CG10565	NP_001246856.1	CbpA	76..282	CDD:225124	44/247 (18%)
		DnaJ	76..145	CDD:278647	18/69 (26%)
		RILP-like	268..>344	CDD:304877	13/114 (11%)
		RAC_head	332..401	CDD:293322	13/77 (17%)
		SANT	584..633	CDD:197842	7/16 (44%)
		SANT	585..632	CDD:238096	6/15 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464426
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930