DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rme-8 and Dnajc13

DIOPT Version :9

Sequence 1:	NP_610467.1	Gene:	Rme-8 / 35939	FlyBaseID:	FBgn0015477	Length:	2408	Species:	Drosophila melanogaster
Sequence 2:	NP_001346669.1	Gene:	Dnajc13 / 235567	MGIID:	2676368	Length:	2248	Species:	Mus musculus

Alignment Length:	2441	Identity:	1126/2441 - (46%)
Similarity:	1562/2441 - (63%)	Gaps:	251/2441 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KENVDLECFLVTKHSWKGRYKRILSIGTAGISTYNPDKLDLTNRWSYSDIVAAAP---SKTTNIP 66
            :||.||.||..|||||:|:|||:.|:||..::||||:.|::||:|.|.||.:.:|   .:.|
Mouse     5 RENKDLACFYTTKHSWRGKYKRVFSVGTHAVTTYNPNTLEVTNQWPYGDICSISPVGKGQGT--- 66

  Fly    67 HDFVITIKK--DKKLDTIKLSSEYRNDILSSILKYYKEFADKPKNAQRFSAYKYHWSGISLPTVL 129
             :|.:|.:|  .||.:|:|.|:|:|.::|:..|::..:||:.....:|::.||:|||....|.||
Mouse    67 -EFNLTFRKGSGKKSETLKFSTEHRTELLTEALRFRTDFAEGKITGRRYNCYKHHWSDAKKPVVL 130

  Fly   130 EVTPCSLDQLDPTTNDVLASYMYKDIEGIIAGISDYEGGIVMAYGGFSRLHLFKALNHHEIVQNI 194
            ||||...||::|.||.||.||.|::|||.: .:|||:||..:.||||||||||.:....||:::.
Mouse   131 EVTPGGFDQINPVTNRVLCSYDYRNIEGFV-DLSDYQGGFCILYGGFSRLHLFSSEQREEIIKSA 194

  Fly   195 AQRSAQFLGIETKILKSQITLEQFERQRFGKFSGDQFQTSSTEFSVHKITPRHPDPVKRILCLTE 259
            .:.:..::||..:|.|..:..||:...||||:|.|:..||..||.|.||:|||.:||||:|.:||
Mouse   195 IEHAGNYIGISLRIRKEPLEFEQYLNLRFGKYSTDESITSLAEFVVQKISPRHSEPVKRVLAVTE 259

  Fly   260 VTLLERDPQTYSVCTLRPLTDVFALVRDKDNLQRFSIEYKNGIVRNYSTNDRDSLLATVLDAVRS 324
            ..|:||||.||::.||:||.:|||||.|.:|.|.|:||:..|.||.||:.:||||||::||.||:
Mouse   260 TCLVERDPATYNIATLKPLGEVFALVCDSENPQLFTIEFIKGQVRKYSSTERDSLLASLLDGVRA 324

  Fly   325 SGNQDVHVRIGNTPRGKRYVPLNSSVDEETEANLMRLVI----NNFQNPSKRYEILERFNANVPH 385
            |||:||.|::..|.:|:|:..|:..:|||.|:..:|.:.    .||.      :.:.|||||:.:
Mouse   325 SGNRDVCVKMAPTHKGQRWGLLSMPIDEEVESLHLRFLAAPPNGNFA------DAVFRFNANISY 383

  Fly   386 SGLNYSVTQDSLFAENKDKLILSALQALAQKELDSPTAQLSNLELEAIFHALTRLLASKVGYAAF 450
            ||:.::||||.||:|||:|||.:|:.||..:|.|   ...||.|||:.|.|:.||:|||.|:.||
Mouse   384 SGVLHAVTQDGLFSENKEKLINNAITALLSQEGD---VVASNAELESQFQAVRRLVASKAGFLAF 445

  Fly   451 TNLPGFREIIGTKVVAALRRKDLAVTYSAIDMINSLMHSVNSDHDLKQEQLNKSSILSSKSFLET 515
            |.||.|||.:|.|||.||:|.:..|.::|:||:.:||..::.|:||:||||||:|:||||.|||.
Mouse   446 TQLPKFRERLGMKVVKALKRSNNGVIHAAVDMLCALMCPMHDDYDLRQEQLNKASLLSSKKFLEN 510

  Fly   516 LLNMWTTHVSHGSGALVLSAMLDFMTFALCVPYSETTDGKQFDTLLELVADRGRYLYKLFQHPSL 580
            ||..:.:||.||:||||:|::|||:|||||.||||||:|:|||.|||:||..||.|:|||||||:
Mouse   511 LLEKFNSHVDHGTGALVISSLLDFLTFALCAPYSETTEGQQFDMLLEMVASNGRTLFKLFQHPSM 575

  Fly   581 AIVKGAGLVLRAIIEEGELQVAQQMQALALDEAALCRHLLVALYTPSNDPTQTTQRQLSRHLIGL 645
            |||||||||::||||||:.::|.:||.|||.|.||.|||..|::|.|:|....|.|||||||:||
Mouse   576 AIVKGAGLVMKAIIEEGDREIATKMQELALSEGALPRHLHTAMFTISSDQRMLTNRQLSRHLVGL 640

  Fly   646 WLTDSEEAMELFKRIFPAGLLTFLESEETVPESDVEEDKLNFRDNLKFAIQHSNKTRKNVIEKHL 710
            |..|:..|..|.|||.|.|||.:|:|.:.|||.|.  |:::.|||:|.|:....|..|....:.|
Mouse   641 WTADNTTATNLLKRILPPGLLAYLDSSDPVPEKDA--DRMHVRDNVKIAMDQYGKFNKVPEWQRL 703

  Fly   711 QG-----------------IKHW--GMNLIEKQDGAAQALKNRPVVLRNRRQKKKTSDVVVNLPF 756
            .|                 :.||  .|.:.:|:|.....:..:|||||.|||:.|   :..|...
Mouse   704 AGKAAKEVEKFAKEKVDLVLMHWRDRMGIAQKEDKNHMNINQKPVVLRKRRQRIK---IEANWDL 765

  Fly   757 FFYSFAKDHSLPNLIWNHKTREELRMCLENELRQFLNDRDLAGQMIVAWNYQEFEVAYQCLADEI 821
            |:|.|::||:..|||||.||||||:..||:|:|.|..||:|....:::||:.||||.|:|||:||
Mouse   766 FYYRFSQDHARSNLIWNFKTREELKDALESEMRTFNIDRELGSASVISWNHHEFEVKYECLAEEI 830

  Fly   822 KIGDYYIRLILEKDDWPQN-LVKDPIELFNALYRRVLCRQRVNDDQMTVFSLQALAKVYRRYHAE 885
            ||||||:||:||:|:..:: .:|...|.||.||.|.|...:||   |....|||||.||.|.|.|
Mouse   831 KIGDYYLRLLLEEDENEESGSIKRSYEFFNELYHRFLLTPKVN---MKCLCLQALAIVYGRCHEE 892

  Fly   886 IGKFNDMSYILQLSDRCLSPSMRDALINLISCLVLEKSNSRALIDH--VQCLVDLITLAHLHKGR 948
            ||.|.|..||:.:.:||.....||.||..::.|:|.|.|.:.|:|.  ::.||||:||||||..|
Mouse   893 IGPFTDTRYIIGMLERCTDKLERDRLILFLNKLILNKKNVKDLMDSNGIRILVDLLTLAHLHVSR 957

  Fly   949 AQLNTKTNVIEAGPNMGTYEEKDWYY-NIEKDGQKPERQGPITYSELKELWQKGLITPKTRCWAI 1012
            |.:..::|||||.|:|....||:||: |.:|     ||.||..:.|::|||.||::..||||||.
Mouse   958 ATVPLQSNVIEASPDMKRESEKEWYFGNADK-----ERSGPYGFHEMQELWAKGMLNAKTRCWAQ 1017

  Fly  1013 GMDGWRSLQQIPQLKWCLIAKGTPLYDETELSSKILDILIKCTSFFPSRTQNGVAVLIPGPKLSR 1077
            ||||||.||.||||||||:|.|..:.:||:|::.||::||....:||||.|:. |::.|.|::.|
Mouse  1018 GMDGWRPLQAIPQLKWCLLASGQAVLNETDLATLILNMLITMCGYFPSRDQDN-AIIRPLPRVKR 1081

  Fly  1078 KLSEFICLPHVVQVCLTHDPGLLERVATLLYQIMEDNPEMPKVYLTGVFYFMLMYTGSNILPITR 1142
            .||:..|||||:|:.||.||.|:|:||.||:.||:|||::|::||:|||:|::||||||:||:.|
Mouse  1082 LLSDSTCLPHVIQLLLTFDPILVEKVAILLHHIMQDNPQLPRLYLSGVFFFIMMYTGSNVLPVAR 1146

  Fly  1143 FLKMTHMKQGFRSEETSQSGIMHRSILGQLLPEAMVCFLENYSAEKFAEIFLGEFDTPEVIWSSE 1207
            |||.||.||.|:||||....|..|||||.:|||||||:||||..|||:|||||||||||.|||||
Mouse  1147 FLKYTHSKQAFKSEETKGQDIFQRSILGHILPEAMVCYLENYEPEKFSEIFLGEFDTPEAIWSSE 1211

  Fly  1208 MRRLLIEKIAAHIADFTPRLRGHTMARYPYLAIPVISYPQLENELFCHIYYLRHLCDTQKFPNWP 1272
            ||||:|||||||:|||||||:.:|.|.|.|..||||:||||||||||:||||:.||||.:||:||
Mouse  1212 MRRLMIEKIAAHLADFTPRLQSNTRALYQYCPIPVINYPQLENELFCNIYYLKQLCDTLRFPDWP 1276

  Fly  1273 ISDPVQLLKHTLDAWRKEVEKKPPQMTIQQAYQDLGIDLTKTPKPDESMIRKSYYKLAQMYHPDK 1337
            |.|||:|||.:||||:||||||||.|:|..||:.|.:.:.: ...|||.|||:|::|||.|||||
Mouse  1277 IKDPVKLLKDSLDAWKKEVEKKPPMMSIDDAYEVLNLPIGQ-GLHDESKIRKAYFRLAQKYHPDK 1340

  Fly  1338 NPNGREIFEKVNQAYEFLCSRNVWSSGGPDPNNIVLILRTQSILFERYPDVLRPYKYAGYPQLIK 1402
            ||.||::|||||:||||||:::.....||||.||:|||:||||||.|:.:.|:||||||||.||:
Mouse  1341 NPEGRDMFEKVNKAYEFLCTKSTKIVDGPDPENIILILKTQSILFNRHKEELQPYKYAGYPMLIR 1405

  Fly  1403 TIRLETRDDELFSKEAQLLTAASELCYHTVHCSALNAEELRREEGIEALLEAYTRCVSILGVDSK 1467
            ||.:||.||.|||||:.||.||:||.:|||:||||||||||||.|:|.|.||::|||::|...||
Mouse  1406 TITMETSDDLLFSKESPLLPAAAELAFHTVNCSALNAEELRRENGLEVLQEAFSRCVAVLNRSSK 1470

  Fly  1468 PDSLHYQVISNVTRCFEVACNFEKCKQKIIQLPQLLSDVCRVVYFKH------TLSVSLVTSLAA 1526
            |..:..||..:::||:.||..||:|::||.::|.::.|:|||:||..      .|:|..|:|.|.
Mouse  1471 PSDMSVQVCGHISRCYSVAAQFEECREKITEMPGIIKDLCRVLYFGKCIPRVAALAVECVSSFAV 1535

  Fly  1527 NNYDLQCQLSRNGVLWSLLLFIFEYDYTLDESGVDVSDKSNQQQLANNLAKMAVLGCIALAGYSM 1591
             ::.||..|.:.|:||.||:::|.|||||:|||:..::::|||::||:|||::|.....|.||..
Mouse  1536 -DFWLQTHLFQAGILWYLLVYLFNYDYTLEESGIQKNEETNQQEVANSLAKLSVHALSRLGGYLS 1599

  Fly  1592 ELRQKPVTGSETNSPAAKAPPVIKPKPSVSAASSSTYTQNAHNPLQSKQLAITSGKEKESDTSSG 1656
            |.:..|                                   .||...|.||
Mouse  1600 EDQATP-----------------------------------ENPTVRKSLA-------------- 1615

  Fly  1657 SSDTASSTPTESEQQQQLTKTRTSAIQQKYIVTGEAKNSLIKQVLDRLLTRYISNQLATVRDSDV 1721
                                                          .:||.||:.:||....::.
Mouse  1616 ----------------------------------------------GMLTPYIARKLAVASATET 1634

  Fly  1722 LKLLTANTRNPYLIWDNGTRAQLKDFLEQQRTASAKETHEDIAQVSELVSSFEFDAHKDELQIGG 1786
            ||:|.:||.:|||:|:|.|||:|.:|||.|:....|:...|....:|    |.:..|..||.:|.
Mouse  1635 LKMLNSNTESPYLMWNNSTRAELLEFLESQQENMIKKGDCDKTYGAE----FVYSEHAKELIVGE 1695

  Fly  1787 IFIRIYNDMPTHPIAQPKLFIMDLLEYLKHAYQFLQYKKNPASTAAPVNATPKMGNDGILTPTLA 1851
            ||:|:||::||..:..||.|...||:|:....|:|.
Mouse  1696 IFVRVYNEVPTFQLEVPKEFAASLLDYIGSQAQYLH----------------------------- 1731

  Fly  1852 PNHPQLQQASTGKSGTTFDEVLTAYNRSKSRKKLETDALTEQQLALQQSKYDFSSDGKIELHITM 1916
                            ||..:..|                        :|.:....|.....:.|
Mouse  1732 ----------------TFMAITHA------------------------AKVESEQHGDRLPRVEM 1756

  Fly  1917 VLKALIAVIKANAEVEIQCIGNFDMIFGFLASNIFPDNSTVKAVALEVVSLVSRNKECVSEVAAC 1981
            .|:||..|||.|...|.:|||:|.:||..|..:   ....|:.:|||||::|:.|::||:.:|..
Mouse  1757 ALEALRNVIKYNPGSESECIGHFKLIFSLLRVH---GAGQVQQLALEVVNIVTSNQDCVNNIAES 1818

  Fly  1982 EILGNYLVALKDPELRASQVKVLETLSGLMNVQEMIKEAQAKGATIYLLDMFCNSRNPQIREMCA 2046
            .:|.|.|..|.  .|.:|:..|||||..|.:..::||||.||||.||||||||||.:||:|...|
Mouse  1819 MVLSNLLALLH--SLPSSRQLVLETLYALASNTKIIKEAMAKGALIYLLDMFCNSTHPQVRSQTA 1881

  Fly  2047 GILAKMTADRLSGPKVRITVSKFLPALFIDAMVESPATSVQLFESIHEHPELIWNDTTRSNVCDA 2111
            .:.||||||:|.|||||||:.||||::|:|||.::|..:|.:||..||:|||||||::|..|...
Mouse  1882 ELFAKMTADKLIGPKVRITLMKFLPSVFMDAMRDNPEAAVHIFEGTHENPELIWNDSSRDKVSTT 1946

  Fly  2112 VADTCQRFYQLQKANSRHVWKDPE---ILKDIVSNEIVVAGVYLRLFVSNPAWTLRKPKQFLSDL 2173
            |.:.....::.|:.|....||.||   ::......|:.|.||:||:|::.|||.||||::||..|
Mouse  1947 VREMMLEHFKNQRDNPDVNWKLPEDFAVVFGEAEGELAVGGVFLRIFIAQPAWVLRKPREFLIAL 2011

  Fly  2174 LDFVVEQIGKSSSEQDVLDLSTTALVELLRSQPNLADDIPVLGHIPKLFNLLSVQ----PKNTLS 2234
            |:.:.|.:.|::...:.|:..|.|.|.|..:||.|||.:|.|||:||:...::.:    ||:.:.
Mouse  2012 LEKLTELLEKNNPHGETLETLTMATVCLFSAQPQLADQVPPLGHLPKVIQAMNHRNNAIPKSAIR 2076

  Fly  2235 VLHQLSLSEFCVSAISQTECVAPLKKCMEHNRDCIEKACEALSRLFKHQHDSLISQSLEVGLIPF 2299
            |:|.||.:|.||.|::..|.:.||...|....|.:..||||::|:|:.:...|::|:|:..|:|:
Mouse  2077 VIHVLSDNELCVRAMASLETIGPLMNGMRKRADTVGLACEAINRMFQKEQSELVAQALKAELVPY 2141

  Fly  2300 LLGLLDS-RLEFVDNPSAVKAQIVAALKGMTHNLNYGDRVTQILLKHPVWAEFKDQRHDLFIADT 2363
            ||.||:. .||.:|:|:|.|||||.|||.||.:|.||::|::||.:..||:.||||:|||||:|:
Mouse  2142 LLKLLEGVGLENLDSPAATKAQIVKALKAMTRSLQYGEQVSEILSRSSVWSAFKDQKHDLFISDS 2206

  Fly  2364 TIRGYLTGVNPTAGYLTAGPAQSVEVLTSPPPIDRD 2399
            ...|||||.. .|||||||.:.|. :...|||:|.:
Mouse  2207 QTAGYLTGPG-VAGYLTAGTSSSA-MSNLPPPVDHE 2240

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rme-8	NP_610467.1	DUF4339	972..1020	CDD:290937	26/48 (54%)
		DnaJ	1304..1356	CDD:278647	30/51 (59%)
		HEAT repeat	2174..2200	CDD:293787	6/25 (24%)
		HEAT repeat	2212..2243	CDD:293787	12/34 (35%)
		HEAT repeat	2253..2282	CDD:293787	11/28 (39%)
		HEAT repeat	2291..2327	CDD:293787	19/36 (53%)
Dnajc13	NP_001346669.1	DUF4339	981..1025	CDD:316732	26/48 (54%)
Dnajc13	NP_001346669.1	DnaJ	1306..1359	CDD:306689	31/53 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830968
Domainoid	1	1.000	901	1.000	Domainoid score	I50
eggNOG	1	0.900	-	-		E1_KOG1789
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13574
Inparanoid	1	1.050	2073	1.000	Inparanoid score	I45
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53869
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007583
OrthoInspector	1	1.000	-	-		oto92568
orthoMCL	1	0.900	-	-		OOG6_103669
Panther	1	1.100	-	-	LDO	PTHR36983
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3172
SonicParanoid	1	1.000	-	-		X5690
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790