DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rme-8 and rme-8

DIOPT Version :9

Sequence 1:	NP_610467.1	Gene:	Rme-8 / 35939	FlyBaseID:	FBgn0015477	Length:	2408	Species:	Drosophila melanogaster
Sequence 2:	NP_492222.2	Gene:	rme-8 / 172594	WormBaseID:	WBGene00004378	Length:	2279	Species:	Caenorhabditis elegans

Alignment Length:	2477	Identity:	930/2477 - (37%)
Similarity:	1401/2477 - (56%)	Gaps:	279/2477 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ENVDLECFLVTKHSWKGRYKRILSIGTAGISTYNPDKLDLTNRWSYSDIVAAAP----SKTTNIP 66
            ||.|:.|:|||||||||:|||:.||||..|:||||:.|::||:|.|.|.::..|    ....:..
Worm     7 ENRDIACYLVTKHSWKGKYKRVFSIGTLAITTYNPNTLEITNQWLYEDFLSVKPLRNGGSNDSKQ 71

  Fly    67 HDFVITIKKDKKLDTIKLSSEYRNDILSSILKYYKEFADKPKNAQRFSAYKYHWSGISLPTVLEV 131
            .::.|.::...|.:.::.||:|..|||:..|::..:||||.......:|:|..||...:|..|..
Worm    72 DEYKIHVRNRGKNNDMRFSSDYTTDILTHCLQFSTKFADKNFEPLTVTAFKQSWSDRRIPVTLRA 136

  Fly   132 TPCSLDQLDPTTNDVLASYMYKDIEGIIAGISDYEGGIVMAYGGFSRLHLFKALNHHEIVQNIAQ 196
            ....|:|:| ....|:.||.||:|.. |..:||..||.|:..|...|.|:|.:.|:.|:|:.|.:
Worm   137 NASCLEQID-NRGVVVQSYPYKNIRS-IGKVSDCPGGFVVDVGEHRRRHMFASSNNEELVKEIRR 199

  Fly   197 RSAQFLGIETKILKSQITLEQFERQRFGKFSGDQFQTSSTEFSVHKITPRHPDPVKRILCLTEVT 261
            .::..:||...|.|.|:|||.|.|.|.|..|.|:..||..||.:.|||.|:..||:|:|||:|..
Worm   200 LASDNIGIIVPIAKEQLTLEDFMRTRLGLCSRDEELTSYAEFKISKITRRNEMPVRRLLCLSETC 264

  Fly   262 LLERDPQTYSVCTLRPLTDVFALVRDKDNLQRFSIEYKNGIVRNYSTNDRDSLLATVLDAVRSSG 326
            ::|||..||:|....||..:..|||.:.:.|:|.:||:||..|.|...:||.:||::||.:|:||
Worm   265 IIERDLATYAVICATPLKHIVCLVRSEKDPQQFIVEYENGDGRAYVAAERDLILASLLDGIRASG 329

  Fly   327 NQDVHVRIGNTPRGKRYVPLNSSVDEETEANLMRLVINNFQNPS-KRYEILERFNANVPHSGLNY 390
            |.:|.|......|..|.:|.::::||::|:..|:.:|  ...|. :|.:::.|||||||:|||.:
Worm   330 NNEVFVCGHRFERNLRVIPFSTNLDEDSESQCMKHII--APPPGLRRCDLIRRFNANVPYSGLRF 392

  Fly   391 SVTQDSLFAENKDKLILSALQALAQKELDSPTAQLSNLELEAIFHALTRLLASKVGYAAFTNLPG 455
            |.:.:..|:|||.|:|::|::|:..:.......:..: :.||....|.||.|||.|:.|||.:.|
Worm   393 SKSHEGFFSENKGKVIVNAIEAVLMENYTKDDKEYKH-KTEAQLQCLRRLFASKSGFQAFTEVNG 456

  Fly   456 FREIIGTKVVAALRRKDLAVTYSAIDMINSLMHSVNSDHDLKQEQLNKSSILSSKSFLETLLNMW 520
            .||.:|:.||..|..|..::.:|.::.:.:||:.::..::|:.|||||.|::||..|:|.||::.
Worm   457 VREKLGSLVVRVLSWKSESIDHSTVEALCALMYPMHDQYELRIEQLNKQSLMSSPKFVENLLDLI 521

  Fly   521 TTHVSHGSGALVLSAMLDFMTFALCVPYSETTDGKQFDTLLELVADRGRYLYKLFQHPSLAIVKG 585
            ..||...:|.||:::||:|:||::|.||||||.|..||.:|:||:.|||..::|||.||:.||||
Worm   522 VLHVDRSTGWLVIASMLNFLTFSVCSPYSETTAGDTFDHILKLVSLRGRSFFRLFQCPSMTIVKG 586

  Fly   586 AGLVLRAIIEEGELQVAQQMQALALDEAALCRHLLVALYTPSNDPTQTTQRQLSRHLIGLWLTDS 650
            ||:|:||||||.:::.::.||.|||.|.|...||.::|.:...|....|.:|||.|||.||:.|:
Worm   587 AGMVMRAIIEEADVETSKSMQMLALSEGAFLTHLFMSLLSTGKDLRVMTNKQLSGHLISLWIADN 651

  Fly   651 EEAMELFKRIFPAGLLTFLESEETVPESDVEEDKLNFRDNLKFAIQHSNKTRKNVIEKHL----- 710
            ::|.:|..|..|.|||.::||:|.||.:  |:|.|..|:|...|   ||:|::|.:::..
Worm   652 QQANDLLIRCLPRGLLNYMESDEKVPVN--EKDLLIVRNNFDAA---SNETKQNAMKEKFDQLRV 711

  Fly   711 -------QGIKHWG----MNLIEKQ-DGAAQALKNRPVVLRNRRQKKKTSDVVVNLPFFFYSFAK 763
                   :.::||.    :|.:.|: ....|..:.:|||||.||.:.:.:   ||...|.|.|:|
Worm   712 TAEAGLERFVQHWDLEQKLNFLPKRVIDEKQQQRQQPVVLRKRRNRVRPN---VNWKLFAYQFSK 773

  Fly   764 DHSLPNLIWNHKTREELRMCLENELRQFLNDRDLAGQ-MIVAWNYQEFEVAYQCLADEIKIGDYY 827
            |||..:||||.|||||.|..::.|.|..:::::.|.. :.:|||:.||::.|..|.:||||||||
Worm   774 DHSQADLIWNEKTREEFRHAMDTETRALISEKEQAPTGLPIAWNHTEFQIRYPSLLEEIKIGDYY 838

  Fly   828 IRLILEKDDWPQNLVKDPIELFNALYRRVLCRQRVNDDQMTVFSLQALAKVYRRYHAEIGKFNDM 892
            :||:|.:.|.....:.:|:|.||.:|.|.|...:|:   |....|:|:|..|.|:|..||.|.|.
Worm   839 LRLLLIEADENATPIHNPLEFFNNVYHRFLLSTKVD---MKCLCLRAMAITYSRHHMTIGAFQDS 900

  Fly   893 SYILQLSDRCLSPSMRDALINLISCLVLEKSNSRALI--DHVQCLVDLITLAHLHKGRAQLNTKT 955
            .|.:::..:|::|..||.|:.|:|.|.|.|.|.|.||  :.:..||||..|||||..||::..:|
Worm   901 KYFVEMLQKCINPLERDHLVLLLSKLALNKDNVRELIISNILPLLVDLCVLAHLHVQRAKVQNQT 965

  Fly   956 NVIEA-GPNMGTYEEKDWYYNIEKDGQKPERQGPITYSELKELWQKGLITPKTRCWAIGMDGWRS 1019
            ||||| ...|.....::|||: :||.   ::.||:::.::|.|:.:..|..|::.||.|||.|.|
Worm   966 NVIEASAEQMAEGGSEEWYYH-DKDA---KQVGPLSFEKMKSLYTEKTIFEKSQIWAAGMDKWMS 1026

  Fly  1020 LQQIPQLKWCL-----------IAKG---TPLYDETELSSKILDILIKCTSFFPSRTQNGVAVLI 1070
            |..:||.:|.:           ..||   ..:.:.|:||...||.:::...|||||..:. .|:.
Worm  1027 LAAVPQFRWTVCQQKDQPNEINTGKGPFQATVMNFTDLSVLCLDTILQMCEFFPSRDSHD-CVVR 1090

  Fly  1071 PGPKLSRKLSEFICLPHVVQVCLTHDPGLLERVATLLYQIMEDNPEMPKVYLTGVFYFMLMYTGS 1135
            |.|.:.::|:|.:.|..:||:.||::|.:::|||.|||.:|:|||.:|::||:|||||:|||.||
Worm  1091 PMPSVKKQLTEPVLLYQLVQLLLTYEPQIVQRVALLLYLVMQDNPFLPRLYLSGVFYFILMYNGS 1155

  Fly  1136 NILPITRFLKMTHMKQGFRSEETSQSGIMHRSILGQLLPEAMVCFLENYSAEKFAEIFLGEFDTP 1200
            |:|||.|||..|||||.|||......| ..:|:|..|||||...:||.|..||:||:||||||.|
Worm  1156 NVLPIARFLHYTHMKQAFRSTLPQFEG-QRQSVLATLLPEAATFYLEQYGPEKYAEVFLGEFDNP 1219

  Fly  1201 EVIWSSEMRRLLIEKIAAHIADFTPRLRGHTMARYPYLAIPVISYPQLENELFCHIYYLRHLCDT 1265
            |:||::.|||.|||:||.|:|||:.||..:..|.|.:..||:|.||:|..|||||:|||||||:.
Worm  1220 EIIWNTAMRRHLIERIAVHVADFSHRLTSNVRALYQFCPIPLIDYPELAQELFCHVYYLRHLCNK 1284

  Fly  1266 QKFPNWPISDPVQLLKHTLDAWRKEVEKKPPQMTIQQAYQDLGIDLTKTPKPDESMIRKSYYKLA 1330
            |:||:|.|.||:..|:..|..|..|:||||..|::..|.:.|.:|||.......:.||:.|||||
Worm  1285 QRFPDWEIRDPIPFLRCCLATWYNELEKKPATMSVDLAREILSVDLTNEEHRKPAFIRRQYYKLA 1349

  Fly  1331 QMYHPDKNPNGREIFEKVNQAYEFLCSRNVWSSGGPDPNNIVLILRTQSILFERYPDVLRPYKYA 1395
            ..|||||||.|||:||::|.|||.|.|....:||.||.:.|||.|:.|||::.||...|..||||
Worm  1350 AKYHPDKNPEGREMFERINAAYELLSSETANNSGMPDSHRIVLCLQAQSIIYSRYSQELSEYKYA 1414

  Fly  1396 GYPQLIKTIRLETRDDELFSK-EAQLLTAASELCYHTVHCSALNAEELRREEGIEALLEAYTRCV 1459
            ||.||||||.||.:|:.||.| ...||:||.||..:|:..||||||:|||:.|:|||:.|:.|||
Worm  1415 GYSQLIKTIDLEAKDEALFIKGGGDLLSAAIELANYTLISSALNAEQLRRDNGLEALVTAFDRCV 1479

  Fly  1460 SILGVDSKPDSLHYQVISNVTRCFEVACNFEKCKQKIIQLPQLLSDVCRVVYFKH-----TLSVS 1519
            .::.:.|.||.:..:|..:|..||..|..||.|:|:::::|.:...:.|::.|.:     |.:..
Worm  1480 PMVTMSSLPDDMAVRVCIHVCDCFATAATFEACRQRLMEMPSIFGALTRLLQFSNLPRLSTAAAQ 1544

  Fly  1520 LVTSLAANNYDLQCQLSRNGVLWSLLLFIFEYDYTLDESGVDVSDKSNQQQLANNLAKMAVLGCI 1584
            .:.::|.:.. ||.||.:.||||.|:..:|.:||||||.||..|:.||:|.|||:||:.:.....
Worm  1545 CIRAMAVDTL-LQFQLFQTGVLWQLVPHLFHFDYTLDEGGVQHSEDSNKQSLANSLARSSCEALA 1608

  Fly  1585 ALAGYSMELRQKPVTGSETNSPAAKAPPVIKPKPSVSAASSSTYTQNAHNPLQSKQLAITSGKEK 1649
            ||||:            ..|:|
Worm  1609 ALAGF------------RENTP------------------------------------------- 1618

  Fly  1650 ESDTSSGSSDTASSTPTESEQQQQLTKTRTSAIQQKYIVTGEAKNSLIKQVLDRLLTRYISNQLA 1714
                                                       .|..::..|..|||.||...:.
Worm  1619 -------------------------------------------DNDGVQASLRALLTPYICRCMK 1640

  Fly  1715 TVRDSDVLKLLTANTRNPYLIWDNGTRAQLKDFLEQQRTASAKETHEDIAQVSELV-SSFEFDAH 1778
            ...:..|||.|.:|..|||:||||||||::.:|:|:.||::        ...|||. :.||...|
Worm  1641 LETNDMVLKTLNSNMENPYMIWDNGTRAEVLEFVERHRTSN--------EPTSELYGAEFELSVH 1697

  Fly  1779 KDELQIGGIFIRIYNDMPTHPIAQPKLFIMDLLEYLKHAYQFLQYKKNPASTAAPVNATPKMGND 1843
            |:||.:|.|||||||:.||..:.:||...:|||:|:|        |.:...|.||   .||..:|
Worm  1698 KNELIVGDIFIRIYNEQPTFALHEPKKVAIDLLDYIK--------KHSAELTGAP---KPKAISD 1751

  Fly  1844 GILTPTLAPNHPQLQQASTGKSGTTFDEVLTAYNRSKSRKKLETDALTEQQLALQQSKYDFSSDG 1908
            .::                        |:........:...|:|
Worm  1752 DLI------------------------EIDWGNGSQANGNSLDT--------------------- 1771

  Fly  1909 KIELHITMVLKALIAVIKAN--------AEVEIQCIGNFDMIFGFLASNIFPDNSTVKAVALEVV 1965
              |..:.|.:.||..::.||        ..|||..||||.::..:|.....|   .::..||:|:
Worm  1772 --ETKVLMTMTALANLVSANPGALFANKKGVEILLIGNFPLLITYLRCRKHP---KLQIAALQVI 1831

  Fly  1966 SLVSRNKECVSEVAACEILGNYLVALKD-PELRASQVKVLETLSGLMNVQEMIKEAQAKGATIYL 2029
            .|.:.|||||:::|.|.:.......|:| |::.|   :||:.|..|.:..::.||....|..:|:
Worm  1832 LLAAANKECVTDLATCNVTTTLFTLLRDQPKMIA---RVLDVLIALSSNGQIGKEMLEHGGLMYI 1893

  Fly  2030 LDMFC--NSRNPQIREMCAGILAKMTADRLSGPKVRITVSKFLPALFIDAMVESPATSVQLFESI 2092
            |.:.|  ||...| |...|.:|||:.||:|:||:....:.||||.:|.|::.:||.|::|:|:|.
Worm  1894 LSILCLTNSDQGQ-RLQAAELLAKLQADKLTGPRWTRFIIKFLPEIFADSLRDSPNTALQMFDSS 1957

  Fly  2093 HEHPELIWNDTTRSNVCDAVADTCQRFYQLQKANSRHVWKDPEI-------------LKDIVSNE 2144
            .|:||||||:.||..| ..:.||     ::.|...:|: |||.:             ..|.::.|
Worm  1958 SENPELIWNEVTRQKV-KGIIDT-----EVGKLYEQHI-KDPTVKWNTTSLADKSCAYGDSINGE 2015

  Fly  2145 IVVAGVYLRLFVSNPAWTLRKPKQFLSDLLDFVVEQIGKSSSEQDVLDLSTTALVELLRSQPNLA 2209
            :||.||::||:|.||.:.:|.||.|.::|::.|:|.:.:.:.|   |||.|.|.|||:|..||.|
Worm  2016 LVVGGVFVRLYVENPGFNVRHPKLFSTELIEKVLELMSRPTPE---LDLVTKAFVELVRHHPNTA 2077

  Fly  2210 DDIPVLGHIPKLFNLLSVQ----PKNTLSVLHQLSLSEFCVSAISQTECVAPLKKCMEHNRDCIE 2270
            |.:|..|::|:....:.:|    .::.:.:|.:||.::||..|:||..|:..:.|.|::....:.
Worm  2078 DQLPSQGYLPQFCTAMCLQNTSASRSAILILQELSENQFCCDALSQLPCIDGIMKSMKNQPSLMR 2142

  Fly  2271 KACEALSRLFKHQHDSLISQSLEVGLIPFLLGLLDSRLEFVDNPSAVKAQIVAALKGMTHNLNYG 2335
            ::..||..|.|.....|..|.|..|::|:||.:|||.:..|.|.:|.:|:||.|||....:|..|
Worm  2143 ESAHALKCLMKRNTGELAQQMLSCGMVPYLLQVLDSSMNGVSNGAAARAEIVDALKSAILDLKVG 2207

  Fly  2336 DRVTQILLKHPVWAEFKDQRHDLFIADTTIRGYLTGVNPTAGYLTAGPAQSVEVLTSPPPIDRDD 2400
            .::.:||.|.||||:|||||||||:.:...:....|....|||||.|......:...|||:.:..
Worm  2208 QKIAEILDKSPVWAQFKDQRHDLFLPEARTQAITGGPTGVAGYLTEGMFNPPPMSNQPPPMHQTS 2272

  Fly  2401 PSARPPI 2407
            ...:||:
Worm  2273 GDFQPPL 2279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rme-8	NP_610467.1	DUF4339	972..1020	CDD:290937	17/47 (36%)
		DnaJ	1304..1356	CDD:278647	27/51 (53%)
		HEAT repeat	2174..2200	CDD:293787	8/25 (32%)
		HEAT repeat	2212..2243	CDD:293787	7/34 (21%)
		HEAT repeat	2253..2282	CDD:293787	6/28 (21%)
		HEAT repeat	2291..2327	CDD:293787	16/35 (46%)
rme-8	NP_492222.2	DUF4339	983..1033	CDD:379517	20/53 (38%)
rme-8	NP_492222.2	DnaJ	1324..1378	CDD:365959	29/53 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156197
Domainoid	1	1.000	696	1.000	Domainoid score	I54
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13574
Inparanoid	1	1.050	1624	1.000	Inparanoid score	I34
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53869
OrthoDB	1	1.010	-	-		D11434at2759
OrthoFinder	1	1.000	-	-		FOG0007583
OrthoInspector	1	1.000	-	-		oto20823
orthoMCL	1	0.900	-	-		OOG6_103669
Panther	1	1.100	-	-	LDO	PTHR36983
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3172
SonicParanoid	1	1.000	-	-		X5690
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.940