DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rme-8 and dnajc13

DIOPT Version :9

Sequence 1:	NP_610467.1	Gene:	Rme-8 / 35939	FlyBaseID:	FBgn0015477	Length:	2408	Species:	Drosophila melanogaster
Sequence 2:	XP_002937780.2	Gene:	dnajc13 / 100486485	XenbaseID:	XB-GENE-5915507	Length:	2244	Species:	Xenopus tropicalis

Alignment Length:	2441	Identity:	1107/2441 - (45%)
Similarity:	1556/2441 - (63%)	Gaps:	252/2441 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KENVDLECFLVTKHSWKGRYKRILSIGTAGISTYNPDKLDLTNRWSYSDIVAAAP---SKTTNIP 66
            :||.||.||..|||||:|:|||:.||||..|:||||:.|::||:|.|.||...:|   .:.|
Frog     5 RENKDLACFYTTKHSWRGKYKRVFSIGTHAITTYNPNTLEVTNQWPYGDICGISPVGKGQGT--- 66

  Fly    67 HDFVITIKK--DKKLDTIKLSSEYRNDILSSILKYYKEFADKPKNAQRFSAYKYHWSGISLPTVL 129
             :|.:|.:|  .||.:|:|.|:|:|.::|:..|::..:|::.....:|::.||:|||.......|
Frog    67 -EFALTFRKGSGKKSETLKFSTEHRTELLTEALRFRTDFSEGKITGRRYNCYKHHWSDTRKLVTL 130

  Fly   130 EVTPCSLDQLDPTTNDVLASYMYKDIEGIIAGISDYEGGIVMAYGGFSRLHLFKALNHHEIVQNI 194
            ||||..:||:||:.|.||.:|.|::||| ...:|.|:||..:.||||||||||.:....||:::.
Frog   131 EVTPGGIDQIDPSNNRVLCTYDYRNIEG-FTEVSGYQGGFCILYGGFSRLHLFASEQREEIIKSA 194

  Fly   195 AQRSAQFLGIETKILKSQITLEQFERQRFGKFSGDQFQTSSTEFSVHKITPRHPDPVKRILCLTE 259
            .:.:..|:||..:..|..:..|.:...|.||:|.|:..||..||.|.|||.||.:||||:|.|||
Frog   195 IEHAGNFIGITLRTRKEPVDFEYYVSLRLGKYSNDESITSLAEFIVQKITSRHTEPVKRLLALTE 259

  Fly   260 VTLLERDPQTYSVCTLRPLTDVFALVRDKDNLQRFSIEYKNGIVRNYSTNDRDSLLATVLDAVRS 324
            ..||||||.||::.||:||.::||||.|.:|.|.|::|:..|.:|.||:.:||||||::||.||:
Frog   260 TCLLERDPATYNIVTLKPLGEIFALVYDPENPQIFTVEFIKGQIRKYSSTERDSLLASLLDGVRA 324

  Fly   325 SGNQDVHVRIGNTPRGKRYVPLNSSVDEETEANLMRLVI----NNFQNPSKRYEILERFNANVPH 385
            |||:||.|::..|.||:|:..|:..||||.|:..:|.:.    .||.      :.:.|||||:.:
Frog   325 SGNRDVCVKMTPTQRGQRWGLLSVPVDEEVESLHLRFLTTPPNGNFA------DAVFRFNANISY 383

  Fly   386 SGLNYSVTQDSLFAENKDKLILSALQALAQKELDSPTAQLSNLELEAIFHALTRLLASKVGYAAF 450
            ||:.::||||.||:|||:|||.:|:.:|..:|.:   ...||.|||:.|.|:.||:|||.|:.||
Frog   384 SGVLHAVTQDGLFSENKEKLINNAITSLLSQEGE---LAASNAELESQFQAVRRLVASKAGFLAF 445

  Fly   451 TNLPGFREIIGTKVVAALRRKDLAVTYSAIDMINSLMHSVNSDHDLKQEQLNKSSILSSKSFLET 515
            |.||.|||.:|.|||.||:|.:..||::||||:.:||..::.|:||:||||||:|:||||.|||.
Frog   446 TQLPKFRERLGVKVVKALKRNNDGVTHAAIDMLCALMCPMHDDYDLRQEQLNKASLLSSKKFLEN 510

  Fly   516 LLNMWTTHVSHGSGALVLSAMLDFMTFALCVPYSETTDGKQFDTLLELVADRGRYLYKLFQHPSL 580
            ||..:..||::|:||||:|::|||:|||||.||||||:|:|||.|||:||..||.|:|||||||:
Frog   511 LLEKFNLHVNYGTGALVISSLLDFLTFALCAPYSETTEGQQFDMLLEMVASNGRTLFKLFQHPSM 575

  Fly   581 AIVKGAGLVLRAIIEEGELQVAQQMQALALDEAALCRHLLVALYTPSNDPTQTTQRQLSRHLIGL 645
            |:|||||||::|||||.:.::|.:||.|||.|.||.|||..:::|.|.|....|.|||||||:||
Frog   576 AVVKGAGLVMKAIIEEADKEIATKMQELALSEGALPRHLHTSMFTISADQRMLTNRQLSRHLVGL 640

  Fly   646 WLTDSEEAMELFKRIFPAGLLTFLESEETVPESDVEEDKLNFRDNLKFAIQHSNKTRK------- 703
            |..|:..::.|.|||.|.|||.:|:|.:.|||.|:  |:::.|||||.|.....|..|
Frog   641 WTADNTTSLNLLKRILPPGLLAYLDSTDPVPEKDI--DRMHIRDNLKIASDQYGKFNKIPEWQRI 703

  Fly   704 -----NVIEKHLQG-----IKHW--GMNLIEKQDGAAQALKNRPVVLRNRRQKKKTSDVVVNLPF 756
                 ..:||..:.     :.||  .|.:.:|:|..:.....:||:||.|||:.|   :.:|...
Frog   704 AGKAAKEVEKFAKEKVDLVLLHWRDRMGIAQKEDRNSMNTAQKPVILRKRRQRIK---IELNWDL 765

  Fly   757 FFYSFAKDHSLPNLIWNHKTREELRMCLENELRQFLNDRDLAGQMIVAWNYQEFEVAYQCLADEI 821
            |:|.|.:||:..|||||.|||||||..||.|:|.|..||:|....:::||:|||||.|.||::||
Frog   766 FYYRFHQDHARSNLIWNFKTREELRDTLEAEMRAFNVDRELGSSTVISWNHQEFEVKYDCLSEEI 830

  Fly   822 KIGDYYIRLILEKDDWPQN-LVKDPIELFNALYRRVLCRQRVNDDQMTVFSLQALAKVYRRYHAE 885
            ||||||:||:||:|:..:| .:|...|.||.||.|.|...:||   |....||||:.||.|.|.|
Frog   831 KIGDYYLRLLLEEDENEENAAIKQSYEFFNELYHRFLLTPKVN---MKCLCLQALSIVYGRCHEE 892

  Fly   886 IGKFNDMSYILQLSDRCLSPSMRDALINLISCLVLEKSNSRALIDH--VQCLVDLITLAHLHKGR 948
            ||.|.|..||:.:.:||.....||.||..::.|:|.|.|.:.::|.  ::.||||:||||||..|
Frog   893 IGPFGDTKYIVGMLERCTDRLERDRLILFLNKLILNKKNVKDIMDSNGIRILVDLLTLAHLHTSR 957

  Fly   949 AQLNTKTNVIEAGPNMGTYEEKDWYY-NIEKDGQKPERQGPITYSELKELWQKGLITPKTRCWAI 1012
            |.:..::|||||.|:|....||:||: |.:|     ||.||.::.|::|.|.||:::|||||||.
Frog   958 ATVPLQSNVIEAAPDMKRESEKEWYFGNADK-----ERSGPYSFVEMQEFWNKGILSPKTRCWAQ 1017

  Fly  1013 GMDGWRSLQQIPQLKWCLIAKGTPLYDETELSSKILDILIKCTSFFPSRTQNGVAVLIPGPKLSR 1077
            ||||||.||.||||||||:|.|..:.:||:|::.||::||...|:||||.|:. |::.|.||:.|
Frog  1018 GMDGWRPLQVIPQLKWCLLAAGQAVLNETDLATLILNMLITMCSYFPSRDQDN-AIIRPLPKVKR 1081

  Fly  1078 KLSEFICLPHVVQVCLTHDPGLLERVATLLYQIMEDNPEMPKVYLTGVFYFMLMYTGSNILPITR 1142
            .|::..||||:.|:.||.||.|:|:|:.|||.||:|||::|:.||||||:|::||||||:|||.|
Frog  1082 LLTDNTCLPHITQLLLTFDPILVEKVSILLYHIMQDNPQLPRFYLTGVFFFIMMYTGSNVLPIAR 1146

  Fly  1143 FLKMTHMKQGFRSEETSQSGIMHRSILGQLLPEAMVCFLENYSAEKFAEIFLGEFDTPEVIWSSE 1207
            |||.||.||.||:||:....|..|||||.:|||||||:||||..|||:|||||||||||.|||||
Frog  1147 FLKHTHAKQAFRTEESKGPDIFQRSILGHILPEAMVCYLENYEPEKFSEIFLGEFDTPEAIWSSE 1211

  Fly  1208 MRRLLIEKIAAHIADFTPRLRGHTMARYPYLAIPVISYPQLENELFCHIYYLRHLCDTQKFPNWP 1272
            ||||:|||||||:|||:|||:.:|.|.|.|..||||:||||||||||:||||:|.|||.|||:||
Frog  1212 MRRLMIEKIAAHLADFSPRLQSNTRALYQYCPIPVINYPQLENELFCNIYYLKHFCDTLKFPDWP 1276

  Fly  1273 ISDPVQLLKHTLDAWRKEVEKKPPQMTIQQAYQDLGIDLTKTPKPDESMIRKSYYKLAQMYHPDK 1337
            |.|||:|||.||:||:||||||||.|:|..||:.||:...: .:.|||.|||:|::|||.|||||
Frog  1277 IKDPVKLLKDTLEAWKKEVEKKPPTMSIDDAYEVLGLSRGQ-GQYDESKIRKAYFRLAQKYHPDK 1340

  Fly  1338 NPNGREIFEKVNQAYEFLCSRNVWSSGGPDPNNIVLILRTQSILFERYPDVLRPYKYAGYPQLIK 1402
            ||.||::|||||:||||||:::.....||||.||:|||:||||||.|:.:.|:||||||||.||:
Frog  1341 NPEGRDMFEKVNKAYEFLCTKSKKVVDGPDPENIILILKTQSILFNRHKEDLQPYKYAGYPMLIR 1405

  Fly  1403 TIRLETRDDELFSKEAQLLTAASELCYHTVHCSALNAEELRREEGIEALLEAYTRCVSILGVDSK 1467
            ||.:||.|::|||| ..||.||:||.||||:||||||||||||.|||.|.:.::||||:|...||
Frog  1406 TITMETSDEQLFSK-VSLLPAATELAYHTVNCSALNAEELRRENGIEVLQDGFSRCVSVLTASSK 1469

  Fly  1468 PDSLHYQVISNVTRCFEVACNFEKCKQKIIQLPQLLSDVCRVVYFKH------TLSVSLVTSLAA 1526
            ||.:..||..::.:|:.||..||.|::||.::|.::.|:|||:|:..      .::|..|:|.|.
Frog  1470 PDDMPVQVCGHICKCYSVAAQFETCREKITEMPNIIKDLCRVLYYGKRVQRLAAMAVECVSSFAV 1534

  Fly  1527 NNYDLQCQLSRNGVLWSLLLFIFEYDYTLDESGVDVSDKSNQQQLANNLAKMAVLGCIALAGYSM 1591
             :|.||..|.:.||||.||.:.|.||:||:|||:..::.:|||::||:|||:::|....|.||
Frog  1535 -DYWLQTHLLQAGVLWHLLAYPFNYDFTLEESGIQKNEDTNQQEVANSLAKLSLLALSRLGGY-- 1596

  Fly  1592 ELRQKPVTGSETNSPAAKAPPVIKPKPSVSAASSSTYTQNAHNPLQSKQLAITSGKEKESDTSSG 1656
                                                                          .||
Frog  1597 --------------------------------------------------------------LSG 1599

  Fly  1657 SSDTASSTPTESEQQQQLTKTRTSAIQQKYIVTGEAKNSLIKQVLDRLLTRYISNQLATVRDSDV 1721
            ..:|                               .:|.::::.|..:||.||:.:|.....:::
Frog  1600 DQET-------------------------------PENPVLRKSLAGMLTPYIARKLTVSSPTEI 1633

  Fly  1722 LKLLTANTRNPYLIWDNGTRAQLKDFLEQQRTASAKETHEDIAQVSELVSSFEFDAHKDELQIGG 1786
            ||:|.:||.:|||:|:|||||:|.::||.|:.:..:....|::..::    |.:..|..||.:|.
Frog  1634 LKMLNSNTESPYLLWNNGTRAELLEYLESQQESMVRRGDCDVSYGAD----FVYSEHSKELIVGD 1694

  Fly  1787 IFIRIYNDMPTHPIAQPKLFIMDLLEYLKHAYQFLQYKKNPASTAAPVNATPKMGNDGILTPTLA 1851
            ||:||||:.||..:..||.|...||:|:....|:|
Frog  1695 IFVRIYNEQPTFQLELPKAFAASLLDYIGSQAQYL------------------------------ 1729

  Fly  1852 PNHPQLQQASTGKSGTTFDEVLTAYNRSKSRKKLETDALTEQQLALQQSKYDFSSDGKIELHITM 1916
              |..:....||                    |:|:|...::   ||:              :.|
Frog  1730 --HTLMALTQTG--------------------KVESDQHVDR---LQR--------------VEM 1755

  Fly  1917 VLKALIAVIKANAEVEIQCIGNFDMIFGFLASNIFPDNSTVKAVALEVVSLVSRNKECVSEVAAC 1981
            .|:||..|||.|...|.:|||:|.::|..|..:   ....|:.:|||||::|:.|::||:.:|..
Frog  1756 ALEALRNVIKHNPGSETECIGHFKLLFSLLRVH---GAGKVQQLALEVVNIVTSNQDCVNNIAES 1817

  Fly  1982 EILGNYLVALKDPELRASQVKVLETLSGLMNVQEMIKEAQAKGATIYLLDMFCNSRNPQIREMCA 2046
            .:|.:.|..|.  .|..|:..||.||..|.:..::||||.||||.||||||||||.:||:|...|
Frog  1818 MVLSSLLSLLH--SLPTSRQLVLATLYALTSSTKIIKEAMAKGALIYLLDMFCNSTHPQVRSQTA 1880

  Fly  2047 GILAKMTADRLSGPKVRITVSKFLPALFIDAMVESPATSVQLFESIHEHPELIWNDTTRSNVCDA 2111
            .:.|||.:|:|.||||||.:.||||.:|:|||.::|..:|.:||..||:|||||||.:|..|...
Frog  1881 ELFAKMISDKLIGPKVRIVLMKFLPGVFMDAMRDNPEAAVHIFEGTHENPELIWNDNSRERVSTT 1945

  Fly  2112 VADTCQRFYQLQKANSRHVWKDPE---ILKDIVSNEIVVAGVYLRLFVSNPAWTLRKPKQFLSDL 2173
            |.:.....::.|..|....||.|:   :.......|::|.||:||:|::.|||.||||::||..|
Frog  1946 VREMMLEHFKQQVENPDANWKLPDDFTVAYGEAQGELLVGGVFLRIFIAQPAWVLRKPREFLVAL 2010

  Fly  2174 LDFVVEQIGKSSSEQDVLDLSTTALVELLRSQPNLADDIPVLGHIPKLFNLLS----VQPKNTLS 2234
            |:...|.:.|:::..:.|:..|.|.|.|..:||.|.|.:|.|||:||:...:|    ..||..:.
Frog  2011 LEKFTELLEKNNAHGETLETITNATVCLFSAQPQLMDQVPPLGHLPKILQAMSHKNNAVPKCAIR 2075

  Fly  2235 VLHQLSLSEFCVSAISQTECVAPLKKCMEHNRDCIEKACEALSRLFKHQHDSLISQSLEVGLIPF 2299
            |:|.|:.:|.||.:::..:.:.||...|:...|.|..|||||:|:|:.:...|::|:|:|.|:|:
Frog  2076 VIHILTDNELCVRSLASLDTIGPLMSGMKKRSDMIGFACEALNRMFQKEQTELVAQALKVDLVPY 2140

  Fly  2300 LLGLLDSR-LEFVDNPSAVKAQIVAALKGMTHNLNYGDRVTQILLKHPVWAEFKDQRHDLFIADT 2363
            ||.||:.: ||.:::|:|.|||||.|||.||.:|.||::|.:||.:..||:.||||:|||||:::
Frog  2141 LLRLLEGQGLENLESPAATKAQIVKALKSMTRSLQYGEQVNEILTRSSVWSAFKDQKHDLFISES 2205

  Fly  2364 TIRGYLTGVNPTAGYLTAGPAQSVEVLTSPPPIDRD 2399
            ...|||||.. .|||||||.:.:|..:. |||:|::
Frog  2206 QTAGYLTGPG-VAGYLTAGSSSTVMPIV-PPPVDQE 2239

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rme-8	NP_610467.1	DUF4339	972..1020	CDD:290937	26/48 (54%)
		DnaJ	1304..1356	CDD:278647	31/51 (61%)
		HEAT repeat	2174..2200	CDD:293787	6/25 (24%)
		HEAT repeat	2212..2243	CDD:293787	12/34 (35%)
		HEAT repeat	2253..2282	CDD:293787	12/28 (43%)
		HEAT repeat	2291..2327	CDD:293787	19/36 (53%)
dnajc13	XP_002937780.2	DUF4339	981..1031	CDD:379517	30/54 (56%)
dnajc13	XP_002937780.2	DnaJ	1306..1364	CDD:365959	34/58 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	864	1.000	Domainoid score	I59
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13574
Inparanoid	1	1.050	2028	1.000	Inparanoid score	I52
OMA	1	1.010	-	-		QHG53869
OrthoDB	1	1.010	-	-		D11434at2759
OrthoFinder	1	1.000	-	-		FOG0007583
OrthoInspector	1	1.000	-	-		oto102867
Panther	1	1.100	-	-	LDO	PTHR36983
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3172
SonicParanoid	1	1.000	-	-		X5690
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110