DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rad51D and RAD51C

DIOPT Version :9

Sequence 1:	NP_610466.2	Gene:	Rad51D / 35937	FlyBaseID:	FBgn0033389	Length:	336	Species:	Drosophila melanogaster
Sequence 2:	XP_006722064.1	Gene:	RAD51C / 5889	HGNCID:	9820	Length:	377	Species:	Homo sapiens

Alignment Length:	269	Identity:	61/269 - (22%)
Similarity:	99/269 - (36%)	Gaps:	91/269 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 ELCGQPGVGKTQLLYTLALN------FVWKHSQAVLFIDTKREFSCKRIQDMLRAREVDEEASER 161
            |:||.||||||||...||::      |.....:|| ||||:..|...|:.|:..|
Human   122 EICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAV-FIDTEGSFMVDRVVDLATA---------- 175

  Fly   162 AMKGIRVVQAATGADINDLLKSFDH-QLTAETHASMQTKLVL----IDSLAACFAFYRGRRMRDV 221
                                 ...| ||.||.|...:.:..|    :|::.:...::|.|...::
Human   176 ---------------------CIQHLQLIAEKHKGEEHRKALEDFTLDNILSHIYYFRCRDYTEL 219

  Fly   222 RKSV------LTELACKIRKLALRGVAFVIGN-------------------VSFFENNKDSCGDD 261
            ...|      |:|.: |:|.:.:.|:||...:                   :|...|::.:....
Human   220 LAQVYLLPDFLSEHS-KVRLVIVDGIAFPFRHDLDDLSLRTRLLNGLAQQMISLANNHRLAVILT 283

  Fly   262 GEQNGDDEEVTRQQ--LEPMLGSYWSSVATLRL-------------SVELPEEED----FTLQDD 307
            .:..   .::.|.|  |.|.||..|...||:||             ..:.|.:::    |.::..
Human   284 NQMT---TKIDRNQALLVPALGESWGHAATIRLIFHWDRKQSRLATLYKSPSQKECTVLFQIKPQ 345

  Fly   308 GLRFIYVIS 316
            |.|...|.|
Human   346 GFRDTVVTS 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rad51D	NP_610466.2	P-loop_NTPase	80..336	CDD:304359	61/269 (23%)
Rad51D	NP_610466.2	radB	80..335	CDD:236482	61/269 (23%)
RAD51C	XP_006722064.1	HHH_5	12..57	CDD:291205
		recomb_radA	21..349	CDD:131290	58/262 (22%)
		Rad51_DMC1_radA	100..348	CDD:238543	58/261 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0468
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810