DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8046 and YJL163C

DIOPT Version :9

Sequence 1:	NP_724761.1	Gene:	CG8046 / 35936	FlyBaseID:	FBgn0033388	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_012372.1	Gene:	YJL163C / 853276	SGDID:	S000003699	Length:	555	Species:	Saccharomyces cerevisiae

Alignment Length:	591	Identity:	109/591 - (18%)
Similarity:	210/591 - (35%)	Gaps:	172/591 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 HAHENLVAKAQRSG---DADPEVASTASEKQRSSGASAIAVGTEFPGNPQASRPQSLGMYLLEPF 67
            :|.|.::::...:|   |.: |.|..:|........|.::|.....|  :..|.:.|.:|.|
Yeast    26 NALEEIISQNDSTGINLDTN-ETAQDSSYDSIRRSPSILSVAKSVEG--EHGRRKLLCLYGL--- 84

  Fly    68 ILILLFAYNFSSTV---LKNEVIYQSCTAGFGYPDSVCQLLGTKNITNETKRIEEQVQPYAAQVT 129
            ::|:..|.:.|.|.   |..:.:.:..:...|:.|||.......:|::.|..|       |..::
Yeast    85 VMIICIAESISMTATIPLVMDKVAEGISDENGHYDSVAVQTIVSSISSSTMMI-------AGAIS 142

  Fly   130 LAMRLVECFIPAFCGLFAGSW---ADHYGRKPLL--MCSFLGYGL---QYLISAAIAYCAMYTQG 186
            :.|              ||.|   :|..||..:.  |......||   .:.:|:.:.|
Yeast   143 IFM--------------AGKWGELSDRIGRVRVFKYMSGIRVIGLLTHVFTLSSKMKY------- 186

  Fly   187 LVSPWWYVLSIVPLSCLGSSVTYSVAAVCFIADVSGGKVRS-YRMIAYEL---AIY----VGLLL 243
              ..|..||:...:...|...........:::|:    |:: :||:...:   .||    ||.:.
Yeast   187 --HKWAIVLTACIVPSFGGLFALVANGNSYVSDI----VKTEHRMVTIGIMMSCIYATMGVGPMF 245

  Fly   244 GSL------GSGYAYEATDAYIVFSISAVCIFT--ALFLMALLLPESL--PARNRTLSTPTTDT- 297
            ||.      |:|:               :.|:|  |..::||::.|::  ..|:.|....:..|
Yeast   246 GSFLVKWTHGNGF---------------IPIYTSIAFVILALIICETIMVEPRHETQMAHSQSTY 295

  Fly   298 ---------------------------------SVVSMLKSLW----STCSKPREHQNRFMLTTI 325
                                             .:::.:|.||    |..|....|      |.|
Yeast   296 TKRREKLRSQSGSDDARNYQSVTYGKFQIMRLMDLLAPVKKLWLKPDSAGSLVPRH------TVI 354

  Fly   326 MVVLLLTAFVSDGSNS---VFYKFMRIKFHWTVKQFTEYETV-GILVPAVAGSGGVLFIWSLRKC 386
            ::::|...||. |:.|   ....|...::.|...:...:.:: ||      |.|.||.:
Yeast   355 LLIVLDILFVC-GTTSCMPALILFSTYEYKWHAVELGYFISILGI------GRGVVLLV------ 406

  Fly   387 TNSAILWLALVSLLSHCSSSLMK--GFALESWQIYVAIGLGV--------------------FKS 429
             .|..|...|..:..|.:.|:.|  .|.::...|.:.:.|.|                    ..:
Yeast   407 -VSPTLLYTLKRIYQHLNHSIDKIDIFCIQFSMIVITLSLFVMIRFGEKTPTSMIIFALLQALSA 470

  Fly   430 LVNPMCRTMITNLLPADERGKIFALLGVLQALSPLISSTLYVAIYTRTLNTEPGIFNVFSAFLFG 494
            ..:|..::.|.........|::|..:.::::...|:...:.:.:|..|::..|.:| ::..|...
Yeast   471 FCSPTLQSGIIKYTSKKHTGEMFGAMALVRSCVMLVIPPILLKLYGSTVSVNPSLF-MYIPFSTS 534

  Fly   495 IGIILL 500
            |..|||
Yeast   535 IVAILL 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8046	NP_724761.1	MFS_1	138..467	CDD:284993	72/418 (17%)
CG8046	NP_724761.1	MFS	141..503	CDD:119392	81/450 (18%)
YJL163C	NP_012372.1	MFS	139..545	CDD:421695	82/465 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344980
Domainoid	1	1.000	56	1.000	Domainoid score	I2684
eggNOG	1	0.900	-	-		E1_KOG2816
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	74	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001349
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_111049
Panther	1	1.100	-	-	O	PTHR23507
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.790