DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8046 and MFSD14A

DIOPT Version :9

Sequence 1:	NP_724761.1	Gene:	CG8046 / 35936	FlyBaseID:	FBgn0033388	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_149044.2	Gene:	MFSD14A / 64645	HGNCID:	23363	Length:	490	Species:	Homo sapiens

Alignment Length:	399	Identity:	86/399 - (21%)
Similarity:	161/399 - (40%)	Gaps:	97/399 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 GSWADHYGRKPLLMCSFLGYGLQYLISAAIAYCAMYTQGLVSPWWYVLSIVPLSCLGSSVTYSVA 212
            |:.:|.:|||            .:|:......||......:||||| .:::.:|.: .:||:||
Human    93 GALSDVWGRK------------SFLLLTVFFTCAPIPLMKISPWWY-FAVISVSGV-FAVTFSV- 142

  Fly   213 AVCFIADVSGGKVRSYRMIAYEL--AIYVGLLLGS------LGSGYAYEATDAYIVFSISAVCIF 269
            ...::||::....||   :||.|  |.:...|:.|      ||..|.    |:.:|...:|:.:.
Human   143 VFAYVADITQEHERS---MAYGLVSATFAASLVTSPAIGAYLGRVYG----DSLVVVLATAIALL 200

  Fly   270 TALFLMALLLPESLPARNRTLSTPTTDTSVVSMLKSLWSTCSKPREHQNRFMLTTIMVVLLLTAF 334
            ...|:: :.:|||||.:.|    |.:..:.:|     |.. :.|.....:....:|::::.:|.|
Human   201 DICFIL-VAVPESLPEKMR----PASWGAPIS-----WEQ-ADPFASLKKVGQDSIVLLICITVF 254

  Fly   335 VS----DGSNSVFYKFMRIKFHWTVKQFTEYETVGILVPAVAGSGGVLFIWS--------LRKCT 387
            :|    .|..|.|:.::|     .:.:|:. |:|...:..:    |:|.|.:        :|...
Human   255 LSYLPEAGQYSSFFLYLR-----QIMKFSP-ESVAAFIAVL----GILSIIAQTIVLSLLMRSIG 309

  Fly   388 NSAILWLALVSLLSHCSSSLMKGFALESWQIYVAIGLGVFKSLVNPMCRTMITNLLPADERGKIF 452
            |...:.|.|...:...:   ..||..|.|.::.|..:....|:..|....:::....||::|.:.
Human   310 NKNTILLGLGFQILQLA---WYGFGSEPWMMWAAGAVAAMSSITFPAVSALVSRTADADQQGVVQ 371

  Fly   453 ALL----GVLQALSPLISSTLYVAIYTRT-----------LNTE-----------PGIFNVFSAF 491
            .::    |:...|.|.:...::...:...           .||.           ||     ..|
Human   372 GMITGIRGLCNGLGPALYGFIFYIFHVELKELPITGTDLGTNTSPQHHFEQNSIIPG-----PPF 431

  Fly   492 LFGIGIILL 500
            |||...:||
Human   432 LFGACSVLL 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8046	NP_724761.1	MFS_1	138..467	CDD:284993	76/342 (22%)
CG8046	NP_724761.1	MFS	141..503	CDD:119392	86/399 (22%)
MFSD14A	NP_149044.2	MFS_MFSD14	37..449	CDD:340945	86/399 (22%)
MFSD14A	NP_149044.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	465..490
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810