DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8046 and CG15553

DIOPT Version :9

Sequence 1:	NP_724761.1	Gene:	CG8046 / 35936	FlyBaseID:	FBgn0033388	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_651841.3	Gene:	CG15553 / 43677	FlyBaseID:	FBgn0039817	Length:	521	Species:	Drosophila melanogaster

Alignment Length:	507	Identity:	184/507 - (36%)
Similarity:	288/507 - (56%)	Gaps:	53/507 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 MYLLEPFILILLFAYNFSSTVLKNEVIYQSCTAGFGYPDSVCQLLGTKNITNETKRIEEQVQPYA 125
            |:.:||.:.:|:|::..|.||::|::|||:||..|.|.::.|:||.:||.|.|.:.||.::|.|.
  Fly    20 MFYIEPVLFMLIFSHMLSGTVMRNQLIYQACTVIFQYNETDCKLLDSKNTTTEIQAIETELQDYV 84

  Fly   126 AQVTLAMRLVECFIPAFCGLFAGSWADHYGRKPLLMCSFLGYGLQYLISAAIAYCAMYTQGLVSP 190
            |.:.|...|.|..:||.||||.|||:|.||||||::.|.:|:....|||:.|.:.:.|.  :|:|
  Fly    85 ANMFLTRTLFESIMPAICGLFVGSWSDQYGRKPLMIVSLVGFSASALISSIICWLSSYY--MVNP 147

  Fly   191 WWYVLSIVPLSCLGSSVTYSVAAVCFIADVSGGKVRSYRMIAYELAIYVGLLLGSLGSGYAYEAT 255
            |||.|:.||.|.||....:||||.|||.|.:..|.|.||||..|:.::|.|..|||.|.:.|.||
  Fly   148 WWYTLAAVPHSVLGGWCVFSVAAFCFITDTTDMKTRPYRMIFMEIILFVALTSGSLLSSFVYAAT 212

  Fly   256 DAYIVFSISAVCIFTALFLMALLLPESL---------PARNRTLSTPTTD----TSVVSM----- 302
            .:..|.|:|.:.:..|...:...|||||         |.:.:.:.....|    |:.:|.
  Fly   213 SSAFVQSLSCLIVIIATLFIIFYLPESLGMSPEEDEIPEKEKNVVVTVLDHKNKTNEISAEAEKT 277

  Fly   303 ------------------------------LKSLWSTCSKPREHQNRFMLTTIMVVLLLTAFVSD 337
                                          :|.::|||.|.||:....::..:.:...::.||:|
  Fly   278 ENCDDPPKYESPEKPLEDKVEKAGLFSIKHVKDMFSTCFKKRENNAHTIIWLVTLAGFVSIFVAD 342

  Fly   338 GSNSVFYKFMRIKFHWTVKQFTEYETVGILVPAVAGSGGVLFIWSLRKCTNSAILWLALVSLLSH 402
            |..:|.|.|:|.:||:||:.||.:||....||.:   |.||.|..|||....:::.|||:||||.
  Fly   343 GVMTVNYLFVRQQFHFTVRDFTIFETFSQSVPML---GAVLGILILRKFFGLSVVALALLSLLSE 404

  Fly   403 CSSSLMKGFALESWQIYVAIGLGVFKSLVNPMCRTMITNLLPADERGKIFALLGVLQALSPLISS 467
            .::::.:|||..||.:|:::.||:|:|:..||.||:::|::|..:.||:||:..:||:.:|.:::
  Fly   405 VAANIARGFAYLSWHLYLSVVLGIFRSIQGPMFRTIVSNIVPPSDTGKLFAIGNILQSFAPFVAA 469

  Fly   468 TLYVAIYTRTLNTEPGIFNVFSAFLFGIGIILLGTVWHKKSRNLVYYEPVFK 519
            .||.|||..:|.:.||.||..||..:|:..||:|.|...|.::..:|....|
  Fly   470 PLYTAIYKESLASNPGGFNFLSAAFYGLAFILIGWVMRIKFKHQKFYAKTLK 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8046	NP_724761.1	MFS_1	138..467	CDD:284993	133/376 (35%)
CG8046	NP_724761.1	MFS	141..503	CDD:119392	148/409 (36%)
CG15553	NP_651841.3	MFS_1	96..469	CDD:284993	133/377 (35%)
CG15553	NP_651841.3	MFS	97..239	CDD:304372	64/143 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458927
Domainoid	1	1.000	92	1.000	Domainoid score	I7560
eggNOG	1	0.900	-	-		E1_KOG2816
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	144	1.000	Inparanoid score	I4421
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D333052at33208
OrthoFinder	1	1.000	-	-		FOG0001349
OrthoInspector	1	1.000	-	-		mtm6480
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23507
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X552
	10	9.900