DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8046 and slc46a1

DIOPT Version :9

Sequence 1:	NP_724761.1	Gene:	CG8046 / 35936	FlyBaseID:	FBgn0033388	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_956579.1	Gene:	slc46a1 / 393255	ZFINID:	ZDB-GENE-040426-1012	Length:	481	Species:	Danio rerio

Alignment Length:	477	Identity:	107/477 - (22%)
Similarity:	195/477 - (40%)	Gaps:	71/477 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 TEFPGNPQASRPQSLGMYLLEPFILILLFAYNFSSTV---LKNEVIYQSCTAGFGYPDSVCQLLG 106
            ||....|..|.|.|:   .:||    ::|...||..:   |..:.::...:...||.       |
Zfish    29 TENKAPPPCSCPLSV---TVEP----VMFLSTFSIVLQAPLCTQYLWDRLSEDVGYN-------G 79

  Fly   107 TK----NITNETKRIEEQVQPYAAQVTLAMRLVECFIPAFCGLFAGSWADHYGRKPLLMCSFLGY 167
            ||    |.:.....::.:|:...|..:|.:.|....:..|..:..|||:|..||:.:|:...||.
Zfish    80 TKTGGCNASTVHDPLQTEVETLTAHWSLYINLGGFLVGLFMVILLGSWSDRAGRRLVLIIPSLGL 144

  Fly   168 GLQYLISAAIAYCAMYTQGLVSPWWYVLSIVPLSCLGSSVTY-SVAAVCF--IADVSGGKVRSYR 229
            .:|    ||:....||.:  :..:|:::..:   |.|.|..: ::.|.||  :||.|....|::|
Zfish   145 AVQ----AAVYLTVMYLK--LPVFWFLIGRI---CSGLSGDFNAILAGCFAYVADTSERGSRTFR 200

  Fly   230 MIAYELAIYVGLLLGSLGSGYAYEATDAYI-VFSISAVCIFTALFLMALLLPESLPARNRTLSTP 293
            :...|..:.:..:..|:..| .:.....|| .|.:......||.....|.:||::....:.....
Zfish   201 VAILEACLGLAGMFASIIGG-QWRRAQGYINPFWLVLATNLTAALYAYLFVPETVTPDPQARLFS 264

  Fly   294 TTDTSVVSMLKSLWSTCSKPREHQNRFMLTTIMVVLLLTAFVSDGSNSVFYKFMRIKFHWTVKQF 358
            |.....|..|.|    ...|...:::..|..:...|::|..:......|.|: :.....|.
Zfish   265 TRHHQAVCRLYS----SDAPPGRRSKLWLYILCFFLVVTVHLGCSDLYVLYE-LSAPLCWG---- 320

  Fly   359 TEYETVGILVPAVAGSGG----VLFIWSL------RKCTNSAILWLALVSLLSHCSSSLMKGFAL 413
                      |.:.|.|.    :.::.||      :.|...:  |:|||.|.|:....::...|.
Zfish   321 ----------PELIGYGSAAKHLAYLTSLTGLRAMQCCLEDS--WVALVGLTSNMVGLVVISVAD 373

  Fly   414 ESWQIYVAIGLGVFKSLVNPMCRTMITNLLPADERGKIFALLGVLQALSPLISSTLYVAIYTRTL 478
            .:..::...||........|:.|:.::.|:...|:|.:||.:..::.|..|:||.::.|:|..||
Zfish   374 TTALMFTGYGLCFLFMASTPVLRSKLSKLVDPAEQGALFASVACVEGLCSLVSSGVFNALYPATL 438

  Fly   479 NTEPGIFNVFSAFLFGIGIILL 500
            :...|.     .|:||..|:|:
Zfish   439 HFMKGF-----PFVFGAAILLI 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8046	NP_724761.1	MFS_1	138..467	CDD:284993	73/342 (21%)
CG8046	NP_724761.1	MFS	141..503	CDD:119392	85/374 (23%)
slc46a1	NP_956579.1	MFS	93..460	CDD:119392	89/399 (22%)
slc46a1	NP_956579.1	MFS_1	114..427	CDD:284993	73/343 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48502
OrthoDB	1	1.010	-	-		D333052at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6480
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23507
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X552
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.930