DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8046 and Mfsd14b

DIOPT Version :9

Sequence 1:	NP_724761.1	Gene:	CG8046 / 35936	FlyBaseID:	FBgn0033388	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001100804.1	Gene:	Mfsd14b / 306687	RGDID:	1308377	Length:	507	Species:	Rattus norvegicus

Alignment Length:	550	Identity:	117/550 - (21%)
Similarity:	195/550 - (35%)	Gaps:	184/550 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 STASEKQRSSGASAIAVGTEFPGNPQAS-RPQSLGMYLLEPFILILLFAYNFSSTVLKNEVIYQS 90
            ||..|.....|..|:|       :|:|| .|:..|.            |...||:.|:
  Rat     2 STDGESPEEPGWKAVA-------SPKASAMPEKRGS------------AQAASSSWLQ------- 40

  Fly    91 CTAGFGYPDSVCQ-------------LLGTKNIT--NETKRIEEQVQPYAAQVTLAMRLVECFIP 140
               |||.| ||..             ||.|..:|  :||          ..|.|.   |:...|.
  Rat    41 ---GFGQP-SVYHAAFVIFFEFFAWGLLTTPMLTVLHET----------FPQHTF---LMNGLIQ 88

  Fly   141 AFCGLFA-------GSWADHYGRKPLLMCSFLGYGLQYLISAAIAYCAMYTQGLVSPWWYVLSIV 198
            ...||.:       |:.:|.:||||            :|:......|.......:||||| ..::
  Rat    89 GVKGLLSFLSAPLIGALSDVWGRKP------------FLLGTVFFTCFPIPLMRISPWWY-FGMI 140

  Fly   199 PLSCLGSSVTYSVAAVCFIADVSGGKVRS--YRMIAYELAIYVGLLLGS------LGSGYAYEAT 255
            .:|.: .|||:|| ...::||.:....||  |..::   |.:...|:.|      |.|.|.
  Rat   141 SVSGV-FSVTFSV-IFAYVADFTQEHERSTAYGWVS---ATFAASLVSSPAIGTYLSSNYG---- 196

  Fly   256 DAYIVFSISAVCIFTALFLMALLLPESLPARNRTLSTPTTDTSVVSMLKSLWSTCSKPREHQNRF 320
            |:.:|...:.|.:....|:: :.:|||||.:.|    |.:..:.:|     |.. :.|.....:.
  Rat   197 DSLVVLVATVVALLDICFIL-VAVPESLPEKIR----PASWGAQIS-----WKQ-ADPFASLKKV 250

  Fly   321 MLTTIMVVLLLTAFVS----DGSNSVFYKFMRIKFHWTVKQFTEYETVGILVPAVAGSGGVLFIW 381
            ...:.::::.:|.|:|    .|..|.|:.::|                     .|.|.|.|
  Rat   251 GKDSTVLLICITVFLSYLPEAGQYSSFFLYLR---------------------QVIGFGSV---- 290

  Fly   382 SLRKCTNSAILWLALVSLLSHCS-----SSLMK----------------------GFALESWQIY 419
                   ..:.::|:|.:||..:     |.||:                      ||..::|.::
  Rat   291 -------KIVAFIAMVGILSILAQTVFLSKLMRSLGNKNTVLLGLGFQILQLAWYGFGAQAWMMW 348

  Fly   420 VAIGLGVFKSLVNPMCRTMITNLLPADERGK----IFALLGVLQALSPLISSTLYVAIYTRTLNT 480
            .|..:....|:..|....:|:....:|::|.    |..:.|:...|.|.:...::...:......
  Rat   349 AAGTVAAMSSITFPAVSALISRNAESDQQGVAQGIITGIRGLCNGLGPALYGFIFYLFHVELNEL 413

  Fly   481 EP----------GIFNVFSAFLFGIGIILL 500
            .|          |.|.....||||..|:|:
  Rat   414 GPKLDSDNDPLQGAFIPGPPFLFGACIVLM 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8046	NP_724761.1	MFS_1	138..467	CDD:284993	78/378 (21%)
CG8046	NP_724761.1	MFS	141..503	CDD:119392	86/419 (21%)
Mfsd14b	NP_001100804.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22		7/26 (27%)
		MFS_MFSD14	47..452	CDD:340945	97/474 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	462..483
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D763423at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820