Protein Alignment CG8046 and SLC46A3

DIOPT Version :10

• Sequence 1: NP_724761.1
• Gene: CG8046 / 35936
• FlyBaseID: FBgn0033388
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_001129391.1
• Gene: SLC46A3 / 283537
• HGNCID: 27501
• Length: 463
• Species: Homo sapiens
• Alignment Length: 496
• Identity: 105/496 - (21%)
• Similarity: 200/496 - (40%)
• Gaps: 93/496 - (18%)

  Fly    64 LEPFILILLFAYNFSSTVLKNEVIYQSC---TAGFGYPD----SVCQLLGTKNITNETKRIEEQV 121
            :||.|.:..||...:.. |..:.:|:..   |..:.:..    |.|:    ||.::.....:|:|
Human     6 VEPAIFLSAFAMTLTGP-LTTQYVYRRIWEETGNYTFSSDSNISECE----KNKSSPIFAFQEEV 65

  Fly   122 QPYAAQVTLAMRLVECFIPAFCGLF-AGSWADHYGRK-PLLMCS--------------FLGYGLQ 170
            |...::..|.|. :...||.....| ..|.:|||||| |:::.|              :..:..|
Human    66 QKKVSRFNLQMD-ISGLIPGLVSTFILLSISDHYGRKFPMILSSVGALATSVWLCLLCYFAFPFQ 129

  Fly   171 YLISAAI--AYCAMYTQGLVSPWWYVLSIVPLSCLGSSVTYSVAAVCFIADVSGGKVRSYRMIAY 233
            .||::..  |:|..||                       |:..|...:|.|    :.:.::....
Human   130 LLIASTFIGAFCGNYT-----------------------TFWGACFAYIVD----QCKEHKQKTI 167

  Fly   234 ELAI---YVGLLLG--SLGSGYAYEATD---AYIVFSIS-AVCIFTALFLMALLLPESLPARNRT 289
            .:||   .:||:.|  .|.|||......   ::::.::| ||.:...||.:...:.| ..::|.|
Human   168 RIAIIDFLLGLVTGLTGLSSGYFIRELGFEWSFLIIAVSLAVNLIYILFFLGDPVKE-CSSQNVT 231

  Fly   290 LSTPTTDTSVVSMLKSLWSTCSKPREHQNRFMLTTIMVVLLLTAFVSDGSNSVFYKF-MRIKFHW 353
            :|......::......|:...|..|    ||:|..::..::...||..|...:|..: :.....|
Human   232 MSCSEGFKNLFYRTYMLFKNASGKR----RFLLCLLLFTVITYFFVVIGIAPIFILYELDSPLCW 292

  Fly   354 TVKQFTEYETVGILVPAVAGSGGVLFIWSLRKCTNSAILWLALVSLLSHCSSSLMKGFALESWQI 418
            . :.|..|   |..:.:.:.....|.||....|...  :.:|.:.:.:..:...|..||..:..:
Human   293 N-EVFIGY---GSALGSASFLTSFLGIWLFSYCMED--IHMAFIGIFTTMTGMAMTAFASTTLMM 351

  Fly   419 YVAIGLGVFKSLVNPMCRTMITNLLPADERGKIFALLGVLQALSPLISSTLYVAIYTRTLNTEPG 483
            ::|....:|..:...:.|:|::.::.:.|:|.:||.:..|:.|..:.:.:.:..||:.|:...||
Human   352 FLARVPFLFTIVPFSVLRSMLSKVVRSTEQGTLFACIAFLETLGGVTAVSTFNGIYSATVAWYPG 416

  Fly   484 IFNVFSAFLFGIGIILLG---------TVWHKKSRNLVYYE 515
            .     .||...|::||.         |.|::.|..|:..|
Human   417 F-----TFLLSAGLLLLPAISLCVVKCTSWNEGSYELLIQE 452

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8046	NP_724761.1	MFS_SLC46	61..504	CDD:340944	101/483 (21%)
SLC46A3	NP_001129391.1	MFS_SLC46A3	3..437	CDD:341006	100/479 (21%)
		Tyrosine-based lysosomal-sorting motif. /evidence=ECO:0000269|PubMed:36741448	446..449		0/2 (0%)