DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8008 and SLC46A2

DIOPT Version :9

Sequence 1:	NP_001137623.1	Gene:	CG8008 / 35935	FlyBaseID:	FBgn0033387	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_149040.3	Gene:	SLC46A2 / 57864	HGNCID:	16055	Length:	475	Species:	Homo sapiens

Alignment Length:	511	Identity:	107/511 - (20%)
Similarity:	189/511 - (36%)	Gaps:	143/511 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 AIETELQPYVANLFLARTLLESIVPAFCGLFIGSWSDHYGRKPLLIVSMIGF--SASFLMMAAIC 142
            |:|.:.|..::|.::...|:..:.|......:|..||.|.||..:.:|::||  |...|::..:.
Human    65 ALEDQQQRAISNFYIIYNLVVGLSPLLSAYGLGWLSDRYHRKISICMSLLGFLLSRLGLLLKVLL 129

  Fly   143 ELSSYYVVNPWWYIM----AAVPHSLLGGNCVFSVAAFCFISDITDCKSRPYRMIFMESLFFIGL 203
            :          |.:.    ||..:.|.||...|........|..:....|..|:|.::.:..:..
Human   130 D----------WPVEVLYGAAALNGLFGGFSAFWSGVMALGSLGSSEGRRSVRLILIDLMLGLAG 184

  Fly   204 TSGSLLSSFVYAAVGSAATIG--ISGCIV---TFATLF--IIFFVPESLHFHKEQETKNAITANV 261
            ..||:.|..::..:...:..|  ::.|.|   :||.|:  ::..||||:  .|..:...|:
Human   185 FCGSMASGHLFKQMAGHSGQGLILTACSVSCASFALLYSLLVLKVPESV--AKPSQELPAV---- 243

  Fly   262 EKECIDSKVPI--TACDLQLD-RVAIDCPPNFMNDEEPGKDKRMELPTPATPAMSFDDDLLAKYV 323
              :.:...|..  |....||| :.|:..||:      |||.|
Human   244 --DTVSGTVGTYRTLDPDQLDQQYAVGHPPS------PGKAK----------------------- 277

  Fly   324 ERLPQKAEERKRQEAEEQAKKAGLFSMVHIRDMISTCFKRRDHHARAIIWLVTLA-MFLSIFVFD 387
               |.|                                             .|:| :|:...::|
Human   278 ---PHK---------------------------------------------TTIALLFVGAIIYD 294

  Fly   388 ----GVMTVMYLFV-REKFHWT--------VRDYTFFETVSHLVPMIGALIGFLILRKVFR-LSV 438
                |.:.|:.||| ||...|.        ...||.|         |.:.:|.|:..:.|| .::
Human   295 LAVVGTVDVIPLFVLREPLGWNQVQVGYGMAAGYTIF---------ITSFLGVLVFSRCFRDTTM 350

  Fly   439 VTLALLAFFSEILNNLAKGFATMPWHMYLSVTLGVFRSISGPMCRTIVSNIVPPSDLGKIFSIKN 503
            :.:.:::|.|   ..|...|....:..|::..:.:|..|.....|:.:|.::..|..||:|.|..
Human   351 IMIGMVSFGS---GALLLAFVKETYMFYIARAVMLFALIPVTTIRSAMSKLIKGSSYGKVFVILQ 412

  Fly   504 VLQSFAPFVAAPLYTLIYKRSLTTYPGLFNFVSSFLYLLSFVFIGYVLRIKYRYKQ 559
            :..:....|.:.||..||:.::..:.|....:||||..|:.:.|..|     .|||
Human   413 LSLALTGVVTSTLYNKIYQLTMDMFVGSCFALSSFLSFLAIIPISIV-----AYKQ 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8008	NP_001137623.1	MFS	101..547	CDD:119392	97/476 (20%)
		MFS_1	101..>261	CDD:284993	38/172 (22%)
		MFS_1	375..>558	CDD:284993	47/197 (24%)
SLC46A2	NP_149040.3	MFS_1	84..421	CDD:284993	86/443 (19%)
SLC46A2	NP_149040.3	MFS	<282..453	CDD:304372	45/182 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154045
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7720
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D333052at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23507
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.800