DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8008 and slc22a18

DIOPT Version :9

Sequence 1:	NP_001137623.1	Gene:	CG8008 / 35935	FlyBaseID:	FBgn0033387	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_001032462.1	Gene:	slc22a18 / 559752	ZFINID:	ZDB-GENE-051120-165	Length:	400	Species:	Danio rerio

Alignment Length:	552	Identity:	100/552 - (18%)
Similarity:	185/552 - (33%)	Gaps:	197/552 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 RNQVIYQTCTVIFHYNESDCKQLDVKNASAEIN--AIETELQPYVANL---------FLARTLLE 100
            :.:|||.|..:                |:.||.  .::..:.||:|..         :|..|:
Zfish     6 KQKVIYITYLI----------------AALEITWMFLQFSITPYLARRLGFDTIWFGYLQTTV-- 52

  Fly   101 SIVPAFCGLFIGSWSDHYGRKPLLIVSMIGFSASFLMMAAICELSSYYVV------NPWWYIMAA 159
            .::....|...|.::|.:|.:..|.||              |..|.:|.:      :|:...:..
Zfish    53 GVIQLLGGPIYGRFADIFGARAALSVS--------------CGASVFYFLPLTVADSPFMLFVHK 103

  Fly   160 VP----HSLLGGNCVFSVAAFCFISDITDCKSRPYRMIFMESLFFIGLTSGSLLSSFVYAAVGS- 219
            :|    |:|.|...|        ::|:::.:.|...:..:...|.||:.:||.|...:....|.
Zfish   104 LPAVFMHALPGAQMV--------VADLSEKEKRAEALGKLGLCFGIGMIAGSSLGGTLSTRFGER 160

  Fly   220 -AATIGISGCIVTFATLFIIFFVPESLHFHKEQETKNAITANVEKECIDSKVPITACDLQLDRVA 283
             ||:.|..|..|:.  :.::.|:|        ::||
Zfish   161 FAASFGAVGSFVSL--MLVLNFIP--------KQTK----------------------------- 186

  Fly   284 IDCPPNFMNDEEPGKDKRMELPTPATPAMSFDDDLLAKYVERLPQKAEERKRQEAEEQAKKAGLF 348
                                  |..||                          |::|:.....:|
Zfish   187 ----------------------TQTTP--------------------------ESDEKGSSKSVF 203

  Fly   349 SMVHIRDMISTCFKRRDHHARAIIWLVTLAMFLSIFVFDGVMTVMYLFVREKFHWTVRDYT-FFE 412
            :|..|..::......:....:.|..|.|           |:..||:..:...|.....:.. :..
Zfish   204 NMGEITRLMKFPGVAKTFTVKIISGLPT-----------GIFQVMFSIIAMNFFQLKAEQNGYLM 257

  Fly   413 TVSHLVPMI--GALIGFLIL----RKVFRLSVVTLALLAFFSEILNNLAK-GFATMPWHMYLSVT 470
            ....:|.|:  ||:||.|..    ..:..|||...:|:.....::.|:.: .|..:|    :..:
Zfish   258 AYFGIVQMVIQGAVIGRLTSSFSENSLLLLSVGVSSLVGLAQALMTNVFQFCFIVIP----MMFS 318

  Fly   471 LGVFRSISGPMCRTIVSNIVPPSD----LGKIFSIKNVLQSFAPFVAAPLYTLIYKRSLTTYPGL 531
            |.||..|:..|    ::..|.|:|    ||...|::::|::..|.:...||        .||.
Zfish   319 LSVFNVITDSM----LTKSVSPADTGTMLGLCASVQSLLRTVGPTIGGFLY--------ETYG-- 369

  Fly   532 FNFVSSFLYL---LSFVFIGYVLRIKYRYKQH 560
               |.||.|:   ::....|.:|....|.:.|
Zfish   370 ---VPSFGYIQCVINAAVFGLLLTTGGRSQTH 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8008	NP_001137623.1	MFS	101..547	CDD:119392	84/472 (18%)
		MFS_1	101..>261	CDD:284993	34/171 (20%)
		MFS_1	375..>558	CDD:284993	43/197 (22%)
slc22a18	NP_001032462.1	MFS	10..389	CDD:119392	96/537 (18%)
slc22a18	NP_001032462.1	MFS_1	10..358	CDD:284993	86/493 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910