DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8008 and AgaP_AGAP005318

DIOPT Version :9

Sequence 1:	NP_001137623.1	Gene:	CG8008 / 35935	FlyBaseID:	FBgn0033387	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	XP_555956.2	Gene:	AgaP_AGAP005318 / 3289944	VectorBaseID:	AGAP005318	Length:	472	Species:	Anopheles gambiae

Alignment Length:	532	Identity:	146/532 - (27%)
Similarity:	258/532 - (48%)	Gaps:	90/532 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 TLEKLRN-LQWEKVFRMFYIEPVVFMLLFSHTLSGTIQRNQVIYQTCTVIFHYNESDCKQLDVKN 73
            :|.:||| .:|.:..:....||.:.:..|:.::|..:..|.:|.||| ::..::..||:.|:..:
Mosquito    22 SLMRLRNAARWREQAQYISFEPALLVFCFAMSISEVVLANHIILQTC-LVEGFDRGDCQLLNTDS 85

  Fly    74 ASAEINAIETELQPYVANLFLARTLLESIVPAFCGLFIGSWSDHYGRKPLLIVSMIGFSASFLMM 138
            .|::...|||::||..||:.:...:::|:||....|.:|:|||.|||||.::::..|...||:::
Mosquito    86 NSSQRAMIETQVQPLAANVTMVIVIIKSVVPVLSALLLGAWSDRYGRKPAMLIASAGVLCSFVLL 150

  Fly   139 AAICELSSYYVVNPWWYIMAAVPHSLLGGNCVFSVAAFCFISDITDCKSRPYRMIFMESLFFIGL 203
            ..:..||....:.||:|..|.:|.|:|||..|.:.|||.::||:|:.::|..||.|||:....|.
Mosquito   151 TLLAFLSMQVTLTPWYYTAAYLPFSVLGGMTVITAAAFSYLSDVTNEQTRTMRMGFMEASMMAGA 215

  Fly   204 TSGSLLSSFVYAAVGSAATIGISGCIVTFATLFIIFFVPESLHFHKEQETKNAITANVEKECIDS 268
            ..|.|.||::...:..|||..|:..::..|.::|..|..:|:           |.:|
Mosquito   216 LLGFLASSYIVEWLNVAATFLIASVLILLAIVYIARFTEDSI-----------ILSN-------- 261

  Fly   269 KVPITACDLQLDRVAIDCPPNFMNDEEPGKDKRMELPTPATPAMSFDDDLLAKYVERLPQKAEER 333
                                                                      ...|.|:
Mosquito   262 ----------------------------------------------------------SNSAVEK 268

  Fly   334 KRQEAEEQAKKAGLFSMVHIRDMISTCFKRRDHHARAIIWLVTLAMFLSIFVFDGVMTVMYLFVR 398
            .|.          |.|...:|::..|.|.||..:.|.|:|.:.|...|:... .|...|.|:|.|
Mosquito   269 LRD----------LLSCERLRELSGTFFMRRSGYVREILWSIVLLTGLTELA-GGSGGVFYMFTR 322

  Fly   399 EKFHWTVRDYTFFETVSHLVPMIGALIGFLILRKVFRLSVVTLALLAFFSEILNNLAKGFATMPW 463
            .||.|.::.:::|:....|:.:.|.:||..||:::...|..|:|:::..|.|:::|..|||:..|
Mosquito   323 RKFGWDLKQFSYFQFTDVLIIIFGNVIGIPILKQILHCSDTTVAIVSIASYIVDSLIMGFASSGW 387

  Fly   464 HMYLSVTLGVFRSISGPMCRTIVSNIVPPSDLGKIFSIKNVLQSFAPFVAAPLYTLIYKRSLTTY 528
            .:||::::.|.:...|....||.|.|:|..|:.|.|::...|.:..|.|:|||:|.:|..::.:.
Mosquito   388 MLYLAISVTVLKGTDGAALMTICSTILPAGDMAKFFTMALSLTAVVPLVSAPLFTFVYNATIESL 452

  Fly   529 PGLFNFVSSFLY 540
            |.:||||::.:|
Mosquito   453 PEVFNFVAASVY 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8008	NP_001137623.1	MFS	101..547	CDD:119392	121/440 (28%)
		MFS_1	101..>261	CDD:284993	54/159 (34%)
		MFS_1	375..>558	CDD:284993	53/166 (32%)
AgaP_AGAP005318	XP_555956.2	MFS	109..256	CDD:304372	52/146 (36%)
AgaP_AGAP005318	XP_555956.2	MFS_1	113..438	CDD:284993	110/412 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	210	1.000	Domainoid score	I6049
eggNOG	1	0.900	-	-		E1_KOG2816
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	293	1.000	Inparanoid score	I5157
OMA	1	1.010	-	-		QHG48502
OrthoDB	1	1.010	-	-		D333052at33208
OrthoFinder	1	1.000	-	-		FOG0001349
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23507
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X552
TreeFam	1	0.960	-	-
	11	10.940