DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8008 and Slc46a2

DIOPT Version :9

Sequence 1:	NP_001137623.1	Gene:	CG8008 / 35935	FlyBaseID:	FBgn0033387	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_066395.3	Gene:	Slc46a2 / 30936	MGIID:	1353616	Length:	479	Species:	Mus musculus

Alignment Length:	554	Identity:	115/554 - (20%)
Similarity:	206/554 - (37%)	Gaps:	131/554 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 YIEPVVFMLLFSHTLSGTIQRNQVIYQTCTVIFHYNESDCKQLDVKNASAEINAI---ETELQPY 88
            :|||||    .|..::|:      :|....::........:.....|.||..:.:   |.:.|..
Mouse    21 WIEPVV----ASTQVAGS------LYDAGLLLVVKESFKSEAGGSSNYSANQSLVEYQEDQQQKA 75

  Fly    89 VANLFLARTLLESIVPAFCGLFIGSWSDHYGRKPLLIVSMIGF--SASFLMMAAICELSSYYVVN 151
            ::|..:...|:..:.|......:|..||.|.||..:..:|:||  |...|::..:.:
Mouse    76 ISNFNIIYNLVLGLTPLLSAYGLGWLSDRYHRKISICTAMLGFLLSRIGLLLKVMLD-------- 132

  Fly   152 PWWYIMAAVPHSLLGGNCVFSVAAFCFISDI--TDCKS--RPYRMIFMESLFFIGLTSGSLLSSF 212
              |.:......:.|.|.|....|.:..:..:  ..|..  |..|:|.::.:..:...|||:.|..
Mouse   133 --WPVEVMYGAAALNGLCGSFSAYWSGVMALGSLGCSEGRRSVRLILIDLVLGLAGFSGSMASGH 195

  Fly   213 VYAAV--GSAATIGISGCIVTFATLFIIFFVPESLHFHKEQETKNAITANVEKECIDSKVPITAC 275
            ::..:  .||..:.::.|.|..|. |.:|:   ||...|..|:|            .:||..|
Mouse   196 LFKQIVGHSAQGLLLTACSVGCAA-FALFY---SLFVLKVPESK------------PNKVHPT-- 242

  Fly   276 DLQLDRVAIDCPPNFMNDE---EPGKDKRMELP-TPATPAMSFDDDLLAKYVERLPQKAEERKRQ 336
                    :|.....|...   :|.:..:..:| .|.||.                 |.:..:|:
Mouse   243 --------VDTVSGMMGTYRTLDPDQQDKQNVPRNPRTPG-----------------KGKSSQRE 282

  Fly   337 EAEEQAKKAGLFSMVHIRDMISTCFKRRDHHARAIIWLVTLAMFLSIFVFD----GVMTVMYLFV 397
                                                  |...:|:...::|    |.:.||.|||
Mouse   283 --------------------------------------VVALLFVGAIIYDLAAVGTVDVMALFV 309

  Fly   398 -REKFHWTVRDYTFFETVSHLVPMIGALIGFLILRKVFR-LSVVTLALLAFFSEILNNLAKGFAT 460
             :|..||......:.....::: .|.:.:|.|:..:.|| .:::.:.:|:|.|   ..|...|..
Mouse   310 LKEPLHWNQVQLGYGMASGYII-FITSFLGVLVFSRCFRDTTMIIIGMLSFGS---GALLLAFVK 370

  Fly   461 MPWHMYLSVTLGVFRSISGPMCRTIVSNIVPPSDLGKIFSIKNVLQSFAPFVAAPLYTLIYKRSL 525
            ..:..|::..:.:|..|.....|:.:|.::..|..||||.|..:..:....|.:.:|..||:.:|
Mouse   371 ETYMFYIARAIMLFALIPITTIRSAMSKLIKDSSYGKIFVILQLCLTLTGVVTSTIYNKIYQLTL 435

  Fly   526 TTYPGLFNFVSSFLYLLSFVFIGYVLRIKYRYKQ 559
            ..:.|....:||||..|:.|.||.|     .|||
Mouse   436 DKFIGTCFVLSSFLSFLAIVPIGVV-----AYKQ 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8008	NP_001137623.1	MFS	101..547	CDD:119392	94/463 (20%)
		MFS_1	101..>261	CDD:284993	37/167 (22%)
		MFS_1	375..>558	CDD:284993	48/188 (26%)
Slc46a2	NP_066395.3	MFS	86..455	CDD:119392	93/463 (20%)
		MFS_1	88..422	CDD:284993	82/428 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	255..277		6/38 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844279
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7720
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8701
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23507
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.790