DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8008 and slcr-46.1

DIOPT Version :9

Sequence 1:	NP_001137623.1	Gene:	CG8008 / 35935	FlyBaseID:	FBgn0033387	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_001033534.2	Gene:	slcr-46.1 / 180736	WormBaseID:	WBGene00016705	Length:	481	Species:	Caenorhabditis elegans

Alignment Length:	558	Identity:	121/558 - (21%)
Similarity:	210/558 - (37%)	Gaps:	147/558 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 IEPVVFMLLFSHTLSGTIQRNQVIYQTCTVIFHYNESDCKQLDVKN---ASAEINAIETELQPYV 89
            :||::|:|...:|..|.:                 ....|::.:|.   |..:|:..:.| :.|.
Worm    18 VEPLMFVLAACNTAVGIV-----------------SPALKEMKMKRVYPAPPDIHGKDLE-KYYN 64

  Fly    90 ANLFLARTLLESI-VPAFC--GLFIGSWSDHYGRK-PLL--IVSMIGFSASFLMMAAICELSSYY 148
            ..:.:.....|.| :|..|  |:..|.:|||.||| |:|  |:|::..:|..::|
Worm    65 KKMVMWDNYYEYINLPIACVFGIIYGGYSDHRGRKYPMLIGILSVLVSNAMNILM---------- 119

  Fly   149 VVNPW---------WYIMAAVPHSLLGG-----NCVFSVAAFCFISDITDCKSRPYRMIFMESLF 199
                |         |....||...:||.     :|:.:..|..|...||    ..|||:.:..:|
Worm   120 ----WDENTDWPLAWTYPTAVVTGVLGDFLLTMSCINAYIADEFPDKIT----LSYRMVVVSIIF 176

  Fly   200 FIGLTSGSLLSSFV-----YAAVGSAATIGISGCIVTFATLFIIFFVPESLHFHKEQETKNAITA 259
            .:|   ..:.|.||     :.:..:...|...|.::||....:|.       ..|:.:|||.:..
Worm   177 SLG---SFVASRFVKDLVKWTSKPTVMIIAEGGYLLTFLVSLLIL-------DQKKPKTKNCLLK 231

  Fly   260 NVEKECIDSKVPITACDLQLDRVAIDCPPNFMNDEEPGKDKRMELPTPATPAMSFDDDLLAKYVE 324
              |.|.|               |.::...|                               :.:.
Worm   232 --EDESI---------------VTVEGSEN-------------------------------QSLA 248

  Fly   325 RLPQKAEERKRQEAEEQAKKAGLF-----SMVHIRDMISTCFKRRDHHARAIIWLVTLAMFLSIF 384
            .||...:|          .|..:|     |.|.|.|......:.|..|.|..::|...|.||..|
Worm   249 SLPNSTQE----------NKLSVFEIIKTSFVAIYDAAKIFLQPRAGHRRLFLYLCFAANFLDQF 303

  Fly   385 VFDGVMTVMYLFVR-EKFHWTVRDYTFFETVSHLVPMIGALIGFLILRKVFRLS---VVTLALLA 445
            |:.....::..:|| ..|.|....|..:::...:|.::|..:|.|..:::|...   ::.||:|:
Worm   304 VWGEEKGLLGTYVRLPPFTWDTSTYADYKSWRPIVQIVGMAVGMLFFKRIFHFRDTFIICLAILS 368

  Fly   446 FFSEILNNLAKGFATMPWHMYLSVTLGVFRSISGPMCRTIVSNIVPPSDLGKIFSIKNVLQSFAP 510
            ....:   |..|.|...|.::.|:..|....:..||..|.::.||...::||.::|.:|.|..|.
Worm   369 MTGCV---LMIGLAQASWLIFASLAPGSLHGLLNPMSYTFIACIVEQDEIGKAYAISSVAQKLAG 430

  Fly   511 FVAAPLYTLIYKRSLTTYPGLFNFVSSFLYLLSFVFIG 548
            ...:.:...||..::..|.|   ||...:..:|||.:|
Worm   431 IAQSLVLQNIYIATVDWYQG---FVWLLMAAISFVAVG 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8008	NP_001137623.1	MFS	101..547	CDD:119392	107/479 (22%)
		MFS_1	101..>261	CDD:284993	45/184 (24%)
		MFS_1	375..>558	CDD:284993	45/178 (25%)
slcr-46.1	NP_001033534.2	NAGidase	<5..116	CDD:369423	29/115 (25%)
slcr-46.1	NP_001033534.2	MFS	72..471	CDD:391944	109/486 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I4344
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D333052at33208
OrthoFinder	1	1.000	-	-		FOG0001349
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23507
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X552
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.020