DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8008 and AgaP_AGAP005317

DIOPT Version :9

Sequence 1:	NP_001137623.1	Gene:	CG8008 / 35935	FlyBaseID:	FBgn0033387	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	XP_315331.4	Gene:	AgaP_AGAP005317 / 1276027	VectorBaseID:	AGAP005317	Length:	486	Species:	Anopheles gambiae

Alignment Length:	521	Identity:	171/521 - (32%)
Similarity:	273/521 - (52%)	Gaps:	87/521 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 EKVFRMFYIEPVVFMLLFSHTLSGTIQRNQVIYQTCTVIFHYNESDCKQLDVKNASAEINAIETE 84
            |:.:|...:||.|.::.|:..:|..:..||::|||||..|..|:|.|.||..:|.:.||..:|..
Mosquito    27 ERKYRYLILEPAVLLIFFAWNVSSAVFANQIVYQTCTGAFGKNKSLCDQLGTENETEEIQQLEKA 91

  Fly    85 LQPYVANLFLARTLLESIVPAFCGLFIGSWSDHYGRKPLLIVSMIGFSASFLMMAAICELSSYYV 149
            :|||.||:.:|::|:|||:||...:|||.|||.|||||:::....|...::.::|.|..||.||.
Mosquito    92 IQPYSANILMAKSLVESIIPALGSMFIGPWSDRYGRKPVIVSCFTGAFLTYAIVALISLLSMYYT 156

  Fly   150 VNPWWYIMAAVPHSLLGGNCVFSVAAFCFISDITDCKSRPYRMIFMESLFFIGLTSGSLLSSFVY 214
            :|||:|::|::..:|.||.|......||:|:|:|..|:|..:|..:|:..|.||.:|:|.||::.
Mosquito   157 INPWYYVLASITTALSGGTCALITGVFCYIADVTVEKTRATKMAIVEAAVFTGLLAGTLSSSYIL 221

  Fly   215 AAVGSAATIGISGCIVTFATLFIIFFVPESLHFHKEQETKNAITANVEKECIDSKVPITACDLQL 279
            ..........|:...|....::|||::.||:..::..||.|
Mosquito   222 RWTNGTTVFAIAAGAVFLGLMYIIFYIEESIKPNELSETNN------------------------ 262

  Fly   280 DRVAIDCPPNFMNDEEPGKDKRMELPTPATPAMSFDDDLLAKYVERLPQKAEERKRQEAEEQAKK 344
                                                                 |.|:
Mosquito   263 -----------------------------------------------------RARE-------- 266

  Fly   345 AGLFSMVHIRDMISTCFKRRDHHARAIIWLVTLAMFLSIFVFDGVMTVMYLFVREKFHWTVRDYT 409
              ||.:..:.:::.||||||.::.|.|||||.||:..:||..||..||..||:||:|.|||:||:
Mosquito   267 --LFRLDLVSELMQTCFKRRPNYDRLIIWLVILALAANIFAMDGSQTVFLLFLRERFEWTVKDYS 329

  Fly   410 FFETVSHLVPMIGALIGFLILRKVFRLSVVTLALLAFFSEILNNLAKGFATMPWHMYLSVTLGVF 474
            :::..:.:..:||...|..::||:|..||..||.|.:....:|:..:..|:.|||:|:...:...
Mosquito   330 YYDASAIVFMIIGNTAGLYVIRKLFNPSVTVLAALGYCCYAINSTIQALASEPWHLYMGTAICFM 394

  Fly   475 RSISGPMCRTIVSNIVPPSDLGKIFSIKNVLQSFAPFVAAPLYTLIYKRSLTTYPGLFNFVSSFL 539
            :.|:|||.|.::||..||:|:|||||:...::|..|..:|||||.:||.:|..|||.||.:::.:
Mosquito   395 KGIAGPMSRAVISNTAPPNDIGKIFSLTTSIESITPLFSAPLYTFVYKSTLAWYPGAFNLITATV 459

  Fly   540 Y 540
            |
Mosquito   460 Y 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8008	NP_001137623.1	MFS	101..547	CDD:119392	139/440 (32%)
		MFS_1	101..>261	CDD:284993	57/159 (36%)
		MFS_1	375..>558	CDD:284993	67/166 (40%)
AgaP_AGAP005317	XP_315331.4	MFS	108..469	CDD:119392	139/440 (32%)
AgaP_AGAP005317	XP_315331.4	MFS_1	108..434	CDD:284993	125/412 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48502
OrthoDB	1	1.010	-	-		D333052at33208
OrthoFinder	1	1.000	-	-		FOG0001349
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23507
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X552
TreeFam	0	0.000	Not matched by this tool.
	7	6.930