DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8008 and AgaP_AGAP004562

DIOPT Version :9

Sequence 1:	NP_001137623.1	Gene:	CG8008 / 35935	FlyBaseID:	FBgn0033387	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	XP_562320.4	Gene:	AgaP_AGAP004562 / 1274703	VectorBaseID:	AGAP004562	Length:	557	Species:	Anopheles gambiae

Alignment Length:	571	Identity:	131/571 - (22%)
Similarity:	226/571 - (39%)	Gaps:	110/571 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EKASNAFTLEKL----RNLQWEKVFRMFYIEPVVFMLLFSHTLSGTIQRNQVIYQTCTVIFHYNE 63
            ||.|.:...||.    ||:.         :||::...:....|:|...:|..:.:.|.|...|.:
Mosquito    21 EKKSPSSLREKYLYFKRNIT---------VEPMLACYIMPSVLAGLATQNLNLEKACRVNLGYGD 76

  Fly    64 SDCKQL---DVKNASAEINAIETELQPYVANLFLARTLLESIVPAFCGLFIGSWSDHYG-RKPLL 124
            ..|..|   |..|.:.|    |..:|..||.:...:|:|:|.:|....||.|||||.:| |||.:
Mosquito    77 VICDALTRRDTANYTHE----EEMVQHLVARMAGWKTVLQSALPCMLILFWGSWSDRHGRRKPCM 137

  Fly   125 IVSMIGFSASFLMMAAICELSSYYVVNPWWY--IMAAVPHSLLGGNCVFSVAAFCFISDITDCKS 187
            ::.:||   .|:....:. |.:|:...|...  |..|:..:|.||.....:..|.:|:|:|..:.
Mosquito   138 LIPIIG---EFMTAIGLI-LCTYFKSVPMEVAGITEALFPALTGGWFTMFMGVFSYIADVTTTEE 198

  Fly   188 RPYRMIFMESLFFIGLTSGSLLSSFVYAAVGSAATIGISGCIVTFATLFIIFFVPESLHFHKEQE 252
            |..|:..:...|.:|:..|...|..:...:|......||..:...|..:.:|.|.|.
Mosquito   199 RTLRIGIVNLCFSLGVPIGMAFSGILLKQIGFYGVFSISASLYLVAFFYGVFVVKEV-------- 255

  Fly   253 TKNAITANVEKECIDSKVPITACDLQLDRVAIDCPPNFMNDEEPGKDKRMELPTPATPAMSFDDD 317
                                                                            |
Mosquito   256 ----------------------------------------------------------------D 256

  Fly   318 LLAKYVERLPQKAEERKRQEAEEQAKKAGLFSMVHIRDMISTCFKRRDHHARAIIWLVTLAMFLS 382
            :|           .|::|..|:|:...|..|...|:.:.....||..:...|..:.::.:.:.:.
Mosquito   257 IL-----------NEKQRLRAQEKGLLADFFDREHVMETFRVAFKIGERQRRLRVIMLMIVVMVV 310

  Fly   383 IFVFDGVMTVMYLFVREKFHWTVRDYTFFETVSHLVPMIGALIGFLILRKVFRLSVVTLALLAFF 447
            |....|.|.|:|||.|.:|:|:..:::||.|...|..:||.|....:...:.::....:.:::..
Mosquito   311 IGPLHGEMAVIYLFTRYRFNWSEVEFSFFSTYGMLTGLIGTLFSVGVFSHLLKIDDALIGVMSCM 375

  Fly   448 SEILNNLAKGFATMPWHMYLSVTLGVFRSISGPMCRTIVSNIVPPSDLGKIFSIKNVLQSFAPFV 512
            |:||::....||...|.:||...:.:....|....|:|.|.:|...:|||:.|:..|.::..|.|
Mosquito   376 SKILSSFVYAFAVTTWQLYLGPIVEMLNGTSFISMRSIASKLVASDELGKVNSLFGVAEALMPLV 440

  Fly   513 AAPLYTLIYKRSLTTYPGLFNFVSSFLYLLSFVFIGYVLRIKYRYKQHYAK 563
            .|||||.:|..|:...||.|..:...|...:.|...::.|:..|..:..|:
Mosquito   441 YAPLYTTVYTLSINVLPGAFFLLGGALTSPAVVIFLWMYRVHRREARELAE 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8008	NP_001137623.1	MFS	101..547	CDD:119392	102/448 (23%)
		MFS_1	101..>261	CDD:284993	41/162 (25%)
		MFS_1	375..>558	CDD:284993	51/182 (28%)
AgaP_AGAP004562	XP_562320.4	MFS	98..479	CDD:119392	107/467 (23%)
AgaP_AGAP004562	XP_562320.4	MFS_1	99..440	CDD:284993	93/427 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48502
OrthoDB	1	1.010	-	-		D333052at33208
OrthoFinder	1	1.000	-	-		FOG0001349
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X552
TreeFam	0	0.000	Not matched by this tool.
	6	5.830