DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8008 and AgaP_AGAP003000

DIOPT Version :9

Sequence 1:	NP_001137623.1	Gene:	CG8008 / 35935	FlyBaseID:	FBgn0033387	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	XP_311884.5	Gene:	AgaP_AGAP003000 / 1272954	VectorBaseID:	AGAP003000	Length:	524	Species:	Anopheles gambiae

Alignment Length:	566	Identity:	122/566 - (21%)
Similarity:	222/566 - (39%)	Gaps:	124/566 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SNAFTLEKLRNLQW-EKVFRMFYIEPVVFMLLFSHTLSGTIQRNQVIYQTCTVIFHYNESDCKQL 69
            :.|.....:|..:| ||:    .:||.:|:.:.:..|:..:::...:|:.|||...|:...|..:
Mosquito    31 AGAMATASVRAERWYEKI----SVEPSMFLYMMAFMLTSVVEQAFFLYKACTVDHGYSHEICLNI 91

  Fly    70 DVKNASAEINAIETELQPYVANLFLARTLLESIVPAFCGLFIGSWSDHYGRKPLLIVSMIGFSAS 134
            :      :...|:.::|...:.......:...:||....||:|:|||..|||..||:.::|   .
Mosquito    92 E------QYQDIKKQVQVTTSTFHQWNNIAMYVVPIVLALFLGAWSDRRGRKLPLILGLMG---K 147

  Fly   135 FLMMAAICELSSYYVVN---PWW---YIM--AAVPHSLLGGNCVFSVAAFCFISDITDCKSRPYR 191
            |:....|       |||   |.|   ||:  |.:|..|.|.:.....:.|.:|||||..:.|..|
Mosquito   148 FVYSVMI-------VVNTRMPSWPVEYIIYTATIPSVLTGADIAIFASCFAYISDITTVEERTLR 205

  Fly   192 MIFMESLFFIGLTSGSLLSSFVYAAVGSAATI------GISGCIVTFATLFIIFFVPESLHFHKE 250
            :..:::.:...:..|..|.:.::...|.:.||      .:..|.:.::.|.:           |.
Mosquito   206 ITILDATYLSTMPIGVALGNVIFNHTGKSYTIMFIINASLLACSIVYSMLRL-----------KS 259

  Fly   251 QETKNAITANVEKECIDSKVPITACDLQLDRVAIDCPPNFMNDEEPGKDKRMELPTPATPAMSFD 315
            :.|        |::|                                  ...|||....|...||
Mosquito   260 RTT--------ERQC----------------------------------SIRELPWYRMPLDFFD 282

  Fly   316 DDLLAKYVERLPQKAEERKRQEAEEQAKKAGLFSMVHIRDMISTCFKRRDHHARAIIWLVTLAMF 380
                               ||               |:...:.|..:||..|.|..::|:.:||.
Mosquito   283 -------------------RQ---------------HVVRSVRTFVRRRTMHRRTYMYLLMVAMS 313

  Fly   381 LSIFVFDGVMTVMYLFVREKFHWTVRDYTFFETVSHLVPMIGALIGFLILRKVFRLSVVTLALLA 445
            ...|..| ....|||:.:.:|:|....|::|:|......::...:|..:..||..|....:.::.
Mosquito   314 FYTFQRD-EKPKMYLYTQLRFNWDTDLYSYFKTYQSAAYVVMMFLGVPLFTKVLGLKDTLIIMIG 377

  Fly   446 FFSEILNNLAKGFATMPWHMYLSVTLGVFRSISGPMCRTIVSNIVPPSDLGKIFSIKNVLQSFAP 510
            ..:.........||.:.|.:|:..|:.....:..|:.|:::|.:||.::.|.|||..:|..:..|
Mosquito   378 ALAHASARFVYIFAQVGWVLYIGATISSVGPVVAPVLRSMISKMVPTNERGIIFSFLSVFDNAVP 442

  Fly   511 FVAAPLYTLIYKRSLTTYPGLFNFVSSFLYLLSFVFIGYVLRIKYR 556
            ..:..|||.:|..|:.|||.....::....::.| ||...:.:..|
Mosquito   443 LFSGVLYTQVYNSSINTYPQAIFLLTMGTQMIVF-FIALAIHMSLR 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8008	NP_001137623.1	MFS	101..547	CDD:119392	102/459 (22%)
		MFS_1	101..>261	CDD:284993	44/173 (25%)
		MFS_1	375..>558	CDD:284993	44/182 (24%)
AgaP_AGAP003000	XP_311884.5	MFS	110..478	CDD:119392	102/466 (22%)
AgaP_AGAP003000	XP_311884.5	MFS_1	110..437	CDD:284993	91/424 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48502
OrthoDB	1	1.010	-	-		D333052at33208
OrthoFinder	1	1.000	-	-		FOG0001349
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X552
TreeFam	0	0.000	Not matched by this tool.
	6	5.830