Protein Alignment Prp38 and PRPF38A

DIOPT Version :10

• Sequence 1: NP_610463.2
• Gene: Prp38 / 35934
• FlyBaseID: FBgn0050342
• Length: 330
• Species: Drosophila melanogaster
• Sequence 2: NP_116253.2
• Gene: PRPF38A / 84950
• HGNCID: 25930
• Length: 312
• Species: Homo sapiens
• Alignment Length: 323
• Identity: 182/323 - (56%)
• Similarity: 228/323 - (70%)
• Gaps: 30/323 - (9%)

  Fly     1 MANRTVKEAKNVHGTNPQYLIEKIIRSRIYDSKYWKEQCFALTAELLVDKAMELRFVGGVYGGNI 65
            |||||||:|.::||||||||:|||||:|||:||||||:||.|||||:||||||||||||||||||
Human     1 MANRTVKDAHSIHGTNPQYLVEKIIRTRIYESKYWKEECFGLTAELVVDKAMELRFVGGVYGGNI 65

  Fly    66 KPTQFLCLTLKMLQIQPEKDIVVEFIKNEEFKYVRALGAFYLRLTGAALDCYKYLEPLYIDNRKL 130
            |||.|||||||||||||||||:|||||||:|||||.|||.|:||||.|:||||||||||.|.||:
Human    66 KPTPFLCLTLKMLQIQPEKDIIVEFIKNEDFKYVRMLGALYMRLTGTAIDCYKYLEPLYNDYRKI 130

  Fly   131 RRQNRAGQFEIVYMDEYIDELLRNDRVCDIILPRIQKRSILEENNEIEPKVSVLDEDLDD-ELPS 194
            :.|||.|:||::::||:|||||.::|||||||||:|||.:|||..::||:||.|:||:|| |...
Human   131 KSQNRNGEFELMHVDEFIDELLHSERVCDIILPRLQKRYVLEEAEQLEPRVSALEEDMDDVESSE 195

  Fly   195 DEEKADE-----------------TNRPKENSTAVRRPRRVRSKS-RSRSRERERRSGQGNSARS 241
            :||:.||                 .::|:.:.|.  |.||.||:| |.|||..:|||......|.
Human   196 EEEEEDEKLERVPSPDHRRRSYRDLDKPRRSPTL--RYRRSRSRSPRRRSRSPKRRSPSPRRERH 258

  Fly   242 RDYYDELEDYDRQRNRVRNRDTHNEDYDRRQNNGRHDRERERQDRDSIRERERDGDRDRRDRE 304
            |       ....:|:|.|:||..:.  .|.::.|.|...|.|....|....::...:.||..|
Human   259 R-------SKSPRRHRSRSRDRRHR--SRSKSPGHHRSHRHRSHSKSPERSKKSHKKSRRGNE 312

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp38	NP_610463.2	PRP38	10..172	CDD:460901	126/161 (78%)
		PRK12678	<193..>330	CDD:237171	35/130 (27%)
PRPF38A	NP_116253.2	N-terminal protein interaction domain. /evidence=ECO:0000269|PubMed:26673105	1..179		137/177 (77%)
		PRP38	10..172	CDD:460901	126/161 (78%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	181..312		42/141 (30%)