Protein Alignment Prp38 and PRPF38A

DIOPT Version :9

• Sequence 1: NP_610463.2
• Gene: Prp38 / 35934
• FlyBaseID: FBgn0050342
• Length: 330
• Species: Drosophila melanogaster
• Sequence 2: XP_011540617.1
• Gene: PRPF38A / 84950
• HGNCID: 25930
• Length: 319
• Species: Homo sapiens
• Alignment Length: 348
• Identity: 184/348 - (52%)
• Similarity: 227/348 - (65%)
• Gaps: 51/348 - (14%)

  Fly     1 MANRTVKEAKNVHGTNPQYLIEKIIRSRIYDSKYWKEQCFALTAELLVDKAMELRFVGGVYGGNI 65
            |||||||:|.::||||||||:|||||:|||:||||||:||.|||||:||||||||||||||||||
Human     1 MANRTVKDAHSIHGTNPQYLVEKIIRTRIYESKYWKEECFGLTAELVVDKAMELRFVGGVYGGNI 65

  Fly    66 KPTQFLCLTLKMLQIQPEKDIVVEFIKNEEFKYVRALGAFYLRLTGAALDCYKYLEPLYIDNRKL 130
            |||.|||||||||||||||||:|||||||:|||||.|||.|:||||.|:||||||||||.|.||:
Human    66 KPTPFLCLTLKMLQIQPEKDIIVEFIKNEDFKYVRMLGALYMRLTGTAIDCYKYLEPLYNDYRKI 130

  Fly   131 RRQNRAGQFEIVYMDEYIDELLRNDRVCDIILPRIQKRSILEENNEIEPKVSVLDEDLDDELPSD 195
            :.|||.|:||::::||:|||||.::|||||||||:|||.:|||..::||:||.|:||:||...|:
Human   131 KSQNRNGEFELMHVDEFIDELLHSERVCDIILPRLQKRYVLEEAEQLEPRVSALEEDMDDVESSE 195

  Fly   196 EEKADETNRPKENSTAVRR--------PRRVRS----KSRSRSRERERRSGQGNSARSRDYYDEL 248
            ||:.::....:..|...||        |||..:    :|||||..|..||.:..|..|..|
Human   196 EEEEEDEKLERVPSPDHRRRSYRDLDKPRRSPTLRYRRSRSRSPRRRSRSPKRRSLTSLFY---- 256

  Fly   249 EDYDRQRNRVRNRDTHNEDYDRRQNNGRHDRERERQDRDSIRERERDGDRDRRDRERER------ 307
                                   ..:.|.:|.|.:..|     |.|...||||.|.|.:
Human   257 -----------------------SPSPRRERHRSKSPR-----RHRSRSRDRRHRSRSKSPGHHR 293

  Fly   308 -ERDRGRHDQRERDSRGERDRRR 329
             .|.|......||..:..:..||
Human   294 SHRHRSHSKSPERSKKSHKKSRR 316

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp38	NP_610463.2	PRP38	10..172	CDD:281379	126/161 (78%)
PRPF38A	XP_011540617.1	PRP38	10..172	CDD:281379	126/161 (78%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144446
Domainoid	1	1.000	282	1.000	Domainoid score	I1675
eggNOG	1	0.900	-	-		E1_KOG2889
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	343	1.000	Inparanoid score	I2343
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54794
OrthoDB	1	1.010	-	-		D1182767at2759
OrthoFinder	1	1.000	-	-		FOG0005867
OrthoInspector	1	1.000	-	-		oto89510
orthoMCL	1	0.900	-	-		OOG6_102388
Panther	1	1.100	-	-	LDO	PTHR23142
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R993
SonicParanoid	1	1.000	-	-		X4261
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800