DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prp38 and prpf38a

DIOPT Version :9

Sequence 1:	NP_610463.2	Gene:	Prp38 / 35934	FlyBaseID:	FBgn0050342	Length:	330	Species:	Drosophila melanogaster
Sequence 2:	NP_001017140.1	Gene:	prpf38a / 549894	XenbaseID:	XB-GENE-979997	Length:	312	Species:	Xenopus tropicalis

Alignment Length:	336	Identity:	178/336 - (52%)
Similarity:	226/336 - (67%)	Gaps:	34/336 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MANRTVKEAKNVHGTNPQYLIEKIIRSRIYDSKYWKEQCFALTAELLVDKAMELRFVGGVYGGNI 65
            |||||||:|.:|||||||||:|||||:|||:||||||:||.|||||:|||||||::|||||||||
Frog     1 MANRTVKDAHSVHGTNPQYLVEKIIRTRIYESKYWKEECFGLTAELVVDKAMELKYVGGVYGGNI 65

  Fly    66 KPTQFLCLTLKMLQIQPEKDIVVEFIKNEEFKYVRALGAFYLRLTGAALDCYKYLEPLYIDNRKL 130
            |||.|||||||||||||||||:|||||||:|||||.|||.|:||||.|.||||||||||.|.||:
Frog    66 KPTPFLCLTLKMLQIQPEKDIIVEFIKNEDFKYVRTLGALYMRLTGTATDCYKYLEPLYNDYRKV 130

  Fly   131 RRQNRAGQFEIVYMDEYIDELLRNDRVCDIILPRIQKRSILEENNEIEPKVSVLDEDLDDELPSD 195
            :.|||.|:||::::||:||:||..:||||:||||:|||.:|||..:::|:||.|:||:|| :.|.
Frog   131 KVQNRNGEFELMHVDEFIDQLLHEERVCDVILPRLQKRFVLEETEQLDPRVSALEEDMDD-VESS 194

  Fly   196 EEKADETNRPKENSTAVRRPRRVRSKSRSRSRERERRSGQGNSARSRDYYDELEDYDRQRNRVRN 260
            ||:.||..:.::.|     |...|...|...|.|...|.:...:|||.        .|:|:|...
Frog   195 EEEEDEDEKGRDPS-----PEHHRRNYRDLDRPRRSPSPRYRRSRSRS--------PRRRSRSPK 246

  Fly   261 RDTHNEDYDRRQNNGRHDRERERQDRDSIRERERDGDRDRRDRERER-------ERDRGRHDQRE 318
            |        |..:..|.:|.|.:..|     |.|...|:||.|.:.:       .|.|......|
Frog   247 R--------RSPSPPRRERHRSKSPR-----RHRSRSRERRHRSKSKSPGHHRSHRHRSHSKSPE 298

  Fly   319 RDSRGERDRRR 329
            |..:..:..||
Frog   299 RSKKSHKKSRR 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prp38	NP_610463.2	PRP38	10..172	CDD:281379	123/161 (76%)
prpf38a	NP_001017140.1	N-terminal protein interaction domain. /evidence=ECO:0000250\|UniProtKB:Q8NAV1	1..179		134/177 (76%)
		PRP38	10..172	CDD:367467	123/161 (76%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	180..312		43/157 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	276	1.000	Domainoid score	I1715
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	337	1.000	Inparanoid score	I2342
OMA	1	1.010	-	-		QHG54794
OrthoDB	1	1.010	-	-		D1182767at2759
OrthoFinder	1	1.000	-	-		FOG0005867
OrthoInspector	1	1.000	-	-		oto103335
Panther	1	1.100	-	-	LDO	PTHR23142
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R993
SonicParanoid	1	1.000	-	-		X4261
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.110