DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prp38 and prpf38a

DIOPT Version :9

Sequence 1:	NP_610463.2	Gene:	Prp38 / 35934	FlyBaseID:	FBgn0050342	Length:	330	Species:	Drosophila melanogaster
Sequence 2:	NP_001003483.1	Gene:	prpf38a / 445089	ZFINID:	ZDB-GENE-040801-225	Length:	313	Species:	Danio rerio

Alignment Length:	344	Identity:	181/344 - (52%)
Similarity:	228/344 - (66%)	Gaps:	52/344 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MANRTVKEAKNVHGTNPQYLIEKIIRSRIYDSKYWKEQCFALTAELLVDKAMELRFVGGVYGGNI 65
            |||||||:|.:|||||||||:|||||:|||:||||||:||.|||||:|||||||:|||||||||:
Zfish     1 MANRTVKDANSVHGTNPQYLVEKIIRTRIYESKYWKEECFGLTAELVVDKAMELKFVGGVYGGNV 65

  Fly    66 KPTQFLCLTLKMLQIQPEKDIVVEFIKNEEFKYVRALGAFYLRLTGAALDCYKYLEPLYIDNRKL 130
            |||.|||||||||||||||||:|||||||:|||||.|||.|:||||.::||||||||||.|.||:
Zfish    66 KPTPFLCLTLKMLQIQPEKDIIVEFIKNEDFKYVRLLGAMYMRLTGTSVDCYKYLEPLYNDYRKI 130

  Fly   131 RRQNRAGQFEIVYMDEYIDELLRNDRVCDIILPRIQKRSILEENNEIEPKVSVLDEDLDDELPSD 195
            :.|||.|:||::::||:|||||..:|:|||||||:|||.:|||...::|::|.|:||| ||:.:.
Zfish   131 KSQNRNGEFELMHVDEFIDELLHAERMCDIILPRLQKRQVLEEAELLDPRISALEEDL-DEVETS 194

  Fly   196 EEKADETNRPKENSTAVRRPRRVRSKSRSRSRERERRSGQGNSARSRDYYDELEDYDRQRNRVRN 260
            ||:.||..:|:                |.:|.|..|||              ..|.||.|.....
Zfish   195 EEEDDEDEKPE----------------RMQSPEPHRRS--------------YRDMDRPRRSPSP 229

  Fly   261 RDTHNEDYDRRQNNGRHDRERERQDRDSIRERERDGDRD---RRDRERERER------------D 310
            |      |.|.::..|..|..:|:.....|||:||..|.   ||.|.|.|||            .
Zfish   230 R------YRRSRSPRRRSRSPKRRSPSPRRERDRDRHRSKSPRRHRSRSRERRHRSKSPGHHRSH 288

  Fly   311 RGRHDQRERDSRGERDRRR 329
            |.|...:..:||.::..:|
Zfish   289 RHRSHSKSPESRSKKSHKR 307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prp38	NP_610463.2	PRP38	10..172	CDD:281379	123/161 (76%)
prpf38a	NP_001003483.1	N-terminal protein interaction domain. /evidence=ECO:0000250\|UniProtKB:Q8NAV1	1..179		134/177 (76%)
		PRP38	11..172	CDD:281379	123/160 (77%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..313		46/163 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577553
Domainoid	1	1.000	276	1.000	Domainoid score	I1704
eggNOG	1	0.900	-	-		E1_KOG2889
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	338	1.000	Inparanoid score	I2343
OMA	1	1.010	-	-		QHG54794
OrthoDB	1	1.010	-	-		D1182767at2759
OrthoFinder	1	1.000	-	-		FOG0005867
OrthoInspector	1	1.000	-	-		oto40495
orthoMCL	1	0.900	-	-		OOG6_102388
Panther	1	1.100	-	-	LDO	PTHR23142
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R993
SonicParanoid	1	1.000	-	-		X4261
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800