DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prp38 and Prpf38a

DIOPT Version :9

Sequence 1:	NP_610463.2	Gene:	Prp38 / 35934	FlyBaseID:	FBgn0050342	Length:	330	Species:	Drosophila melanogaster
Sequence 2:	NP_001100142.1	Gene:	Prpf38a / 298374	RGDID:	1311129	Length:	312	Species:	Rattus norvegicus

Alignment Length:	321	Identity:	181/321 - (56%)
Similarity:	227/321 - (70%)	Gaps:	26/321 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MANRTVKEAKNVHGTNPQYLIEKIIRSRIYDSKYWKEQCFALTAELLVDKAMELRFVGGVYGGNI 65
            |||||||:|.::||||||||:|||||:|||:||||||:||.|||||:|||||||:||||||||||
  Rat     1 MANRTVKDAHSIHGTNPQYLVEKIIRTRIYESKYWKEECFGLTAELVVDKAMELKFVGGVYGGNI 65

  Fly    66 KPTQFLCLTLKMLQIQPEKDIVVEFIKNEEFKYVRALGAFYLRLTGAALDCYKYLEPLYIDNRKL 130
            |||.|||||||||||||||||:|||||||:|||||.|||.|:||||.|:||||||||||.|.||:
  Rat    66 KPTPFLCLTLKMLQIQPEKDIIVEFIKNEDFKYVRMLGALYMRLTGTAIDCYKYLEPLYNDYRKI 130

  Fly   131 RRQNRAGQFEIVYMDEYIDELLRNDRVCDIILPRIQKRSILEENNEIEPKVSVLDEDLDDELPSD 195
            :.|||.|:||::::||:|||||.::|||||||||:|||.:|||..::||:||.|:||:||...|:
  Rat   131 KSQNRNGEFELMHVDEFIDELLHSERVCDIILPRLQKRYVLEEAEQLEPRVSALEEDMDDVESSE 195

  Fly   196 EEKADETNRPKENSTAVRR--------PRRV------RSKSRS---RSRERERRSGQGNSARSRD 243
            ||:.::....:..|...||        |||.      ||:|||   |||..:|||......|.|
  Rat   196 EEEEEDEKLERVPSPDHRRRSYRDLDKPRRSPALRYRRSRSRSPRRRSRSPKRRSPSPRRERHR- 259

  Fly   244 YYDELEDYDRQRNRVRNRDTHNEDYDRRQNNGRHDRERERQDRDSIRERERDGDRDRRDRE 304
                  ....:|:|.|:||..:.  .|.::.|.|...|.|....|....::...:.||..|
  Rat   260 ------SKSPRRHRSRSRDRRHR--SRSKSPGHHRSHRHRSHSKSPERSKKSHKKSRRGNE 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prp38	NP_610463.2	PRP38	10..172	CDD:281379	125/161 (78%)
Prpf38a	NP_001100142.1	PRP38	10..172	CDD:397446	125/161 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338158
Domainoid	1	1.000	279	1.000	Domainoid score	I1617
eggNOG	1	0.900	-	-		E1_KOG2889
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	341	1.000	Inparanoid score	I2274
OMA	1	1.010	-	-		QHG54794
OrthoDB	1	1.010	-	-		D1182767at2759
OrthoFinder	1	1.000	-	-		FOG0005867
OrthoInspector	1	1.000	-	-		oto96633
orthoMCL	1	0.900	-	-		OOG6_102388
Panther	1	1.100	-	-	LDO	PTHR23142
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4261
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770