DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment shrb and CHMP4C

DIOPT Version :9

Sequence 1:	NP_610462.3	Gene:	shrb / 35933	FlyBaseID:	FBgn0086656	Length:	226	Species:	Drosophila melanogaster
Sequence 2:	NP_689497.1	Gene:	CHMP4C / 92421	HGNCID:	30599	Length:	233	Species:	Homo sapiens

Alignment Length:	238	Identity:	118/238 - (49%)
Similarity:	161/238 - (67%)	Gaps:	19/238 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSFFGKMFGG----KKEVAPTTGEAIQKLRETENMLIKKQEFLEAKIEDELNIARKNASKNKRVA 61
            ||..||.|.|    |...||:..||:.:|||||.||.||||:||.:|:.|:.:|:|:.::|||.|
Human     1 MSKLGKFFKGGGSSKSRAAPSPQEALVRLRETEEMLGKKQEYLENRIQREIALAKKHGTQNKRAA 65

  Fly    62 LQALKKKKRLEKQLQQIDGTLSTIEMQREALESANTNTAVLTTMKNAADALKRAHQNMDVDKVHD 126
            |||||:|||.||||.||||||||||.||||||:::|||.||..|..||.|:|..|:|||::|:.|
Human    66 LQALKRKKRFEKQLTQIDGTLSTIEFQREALENSHTNTEVLRNMGFAAKAMKSVHENMDLNKIDD 130

  Fly   127 MMDDIAEQQDVAREISDAISNPVAFGADLDDEDLERELDELEQENFDKEIIGIPEPTPTLPEAPT 191
            :|.:|.||||:|:|||:|.|..|.||.|.|:::|..||:|||||..:|::..|     .||..|:
Human   131 LMQEITEQQDIAQEISEAFSQRVGFGDDFDEDELMAELEELEQEELNKKMTNI-----RLPNVPS 190

  Fly   192 EDLPEKAKEK---------KKATTTTAVEDDDDPDMKQLLSWS 225
            ..||.:...|         .:|.::...|::|| |:|||.:|:
Human   191 SSLPAQPNRKPGMSSTARRSRAASSQRAEEEDD-DIKQLAAWA 232

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shrb	NP_610462.3	Snf7	20..193	CDD:281366	97/172 (56%)
CHMP4C	NP_689497.1	Intramolecular interaction with C-terminus. /evidence=ECO:0000250	1..153		88/151 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24		9/22 (41%)
		Snf7	24..190	CDD:308778	96/170 (56%)
		Intramolecular interaction with N-terminus. /evidence=ECO:0000250	154..233		29/85 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	173..233		19/66 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	212	1.000	Domainoid score	I2777
eggNOG	1	0.900	-	-		E1_KOG1656
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	240	1.000	Inparanoid score	I3345
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53573
OrthoDB	1	1.010	-	-		D1490465at2759
OrthoFinder	1	1.000	-	-		FOG0001179
OrthoInspector	1	1.000	-	-		otm51487
orthoMCL	1	0.900	-	-		OOG6_100985
Panther	1	1.100	-	-	O	PTHR22761
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1162
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.840