DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment shrb and Chmp4c

DIOPT Version :9

Sequence 1:	NP_610462.3	Gene:	shrb / 35933	FlyBaseID:	FBgn0086656	Length:	226	Species:	Drosophila melanogaster
Sequence 2:	NP_079795.1	Gene:	Chmp4c / 66371	MGIID:	1913621	Length:	232	Species:	Mus musculus

Alignment Length:	234	Identity:	117/234 - (50%)
Similarity:	158/234 - (67%)	Gaps:	12/234 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSFFGKMFGG----KKEVAPTTGEAIQKLRETENMLIKKQEFLEAKIEDELNIARKNASKNKRVA 61
            ||..||.|.|    :...||:..||:.:|||||.||.||||:||.:|:.||.:|:|:.|:|||.|
Mouse     1 MSKLGKFFKGTRSSRARAAPSAQEALARLRETEEMLAKKQEYLENRIQRELALAKKHGSQNKRAA 65

  Fly    62 LQALKKKKRLEKQLQQIDGTLSTIEMQREALESANTNTAVLTTMKNAADALKRAHQNMDVDKVHD 126
            |||||:|||.||||.|:||||||||.||||||:::|||.||..|..||.|:|..|.|||::|:.|
Mouse    66 LQALKRKKRFEKQLTQVDGTLSTIEFQREALENSHTNTEVLRNMGFAAKAMKAVHDNMDLNKIDD 130

  Fly   127 MMDDIAEQQDVAREISDAISNPVAFGADLDDEDLERELDELEQENFDKEI--IGIPE-PTPTLPE 188
            :|.||.||||:|:|||:|.|..|.|....|:.:|..||:|||||..:|::  :.:|. |:.:||.
Mouse   131 LMQDITEQQDIAQEISEAFSQRVQFADGFDEAELLAELEELEQEELNKKMTSLELPNVPSSSLPA 195

  Fly   189 APTE--DLPEKAKEKKKATTTTAVEDDDDPDMKQLLSWS 225
            .|:.  .:|......:.|::..|.|||   |.|||.:|:
Mouse   196 QPSRKASMPSSVHRSRAASSRRAEEDD---DFKQLAAWA 231

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shrb	NP_610462.3	Snf7	20..193	CDD:281366	98/177 (55%)
Chmp4c	NP_079795.1	Intramolecular interaction with C-terminus. /evidence=ECO:0000250	1..153		89/151 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23		8/21 (38%)
		Snf7	24..190	CDD:281366	94/165 (57%)
		Intramolecular interaction with N-terminus. /evidence=ECO:0000250	154..232		27/81 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	177..232		17/58 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	212	1.000	Domainoid score	I2770
eggNOG	1	0.900	-	-		E1_KOG1656
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	241	1.000	Inparanoid score	I3325
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53573
OrthoDB	1	1.010	-	-		D1490465at2759
OrthoFinder	1	1.000	-	-		FOG0001179
OrthoInspector	1	1.000	-	-		otm44285
orthoMCL	1	0.900	-	-		OOG6_100985
Panther	1	1.100	-	-	O	PTHR22761
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1162
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840