DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment shrb and CHMP4B

DIOPT Version :9

Sequence 1:	NP_610462.3	Gene:	shrb / 35933	FlyBaseID:	FBgn0086656	Length:	226	Species:	Drosophila melanogaster
Sequence 2:	NP_789782.1	Gene:	CHMP4B / 128866	HGNCID:	16171	Length:	224	Species:	Homo sapiens

Alignment Length:	231	Identity:	136/231 - (58%)
Similarity:	166/231 - (71%)	Gaps:	16/231 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSFFGKMF---GGKK-EVAPTTGEAIQKLRETENMLIKKQEFLEAKIEDELNIARKNASKNKRVA 61
            ||.|||:|   |||. :..||..||||:||:||.||.|||||||.|||.||..|:|:.:||||.|
Human     1 MSVFGKLFGAGGGKAGKGGPTPQEAIQRLRDTEEMLSKKQEFLEKKIEQELTAAKKHGTKNKRAA 65

  Fly    62 LQALKKKKRLEKQLQQIDGTLSTIEMQREALESANTNTAVLTTMKNAADALKRAHQNMDVDKVHD 126
            |||||:|||.||||.||||||||||.||||||:|||||.||..|..||.|:|.||.|||:|||.:
Human    66 LQALKRKKRYEKQLAQIDGTLSTIEFQREALENANTNTEVLKNMGYAAKAMKAAHDNMDIDKVDE 130

  Fly   127 MMDDIAEQQDVAREISDAISNPVAFGADLDDEDLERELDELEQENFDKEIIGI--PEPTPTLPEA 189
            :|.|||:||::|.|||.|||.||.||.:.|:::|..||:|||||..||.::.|  ||..| ||..
Human   131 LMQDIADQQELAEEISTAISKPVGFGEEFDEDELMAELEELEQEELDKNLLEISGPETVP-LPNV 194

  Fly   190 PTEDLPEKAKEKKKATTTTAVEDDDDPDMKQLLSWS 225
            |:..||.|..:||        |::|| |||:|.:|:
Human   195 PSIALPSKPAKKK--------EEEDD-DMKELENWA 221

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shrb	NP_610462.3	Snf7	20..193	CDD:281366	112/174 (64%)
CHMP4B	NP_789782.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23		11/21 (52%)
		Snf7	24..198	CDD:397437	112/174 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	185..224		19/47 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147406
Domainoid	1	1.000	212	1.000	Domainoid score	I2777
eggNOG	1	0.900	-	-		E1_KOG1656
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H57102
Inparanoid	1	1.050	240	1.000	Inparanoid score	I3345
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53573
OrthoDB	1	1.010	-	-		D1490465at2759
OrthoFinder	1	1.000	-	-		FOG0001179
OrthoInspector	1	1.000	-	-		otm51487
orthoMCL	1	0.900	-	-		OOG6_100985
Panther	1	1.100	-	-	LDO	PTHR22761
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1365
SonicParanoid	1	1.000	-	-		X1162
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.800