DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alc and PRKAB1

DIOPT Version :9

Sequence 1:	NP_610460.1	Gene:	alc / 35931	FlyBaseID:	FBgn0260972	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_006244.2	Gene:	PRKAB1 / 5564	HGNCID:	9378	Length:	270	Species:	Homo sapiens

Alignment Length:	194	Identity:	122/194 - (62%)
Similarity:	146/194 - (75%)	Gaps:	6/194 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 ALPTVLRWDGGGKNVTISGTFSDWKPMAMVRSHQNFVTIIDLPEGDHQYKFCVDGEWKHDPKLKS 218
            |.|||.||.||||.|.:||:|::|..:.:.|||.|||.|:|||||:|||||.|||:|.|||....
Human    77 ARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPI 141

  Fly   219 VENAEGQRNNLVSVRESDFEVFQALAKDSENVTNYAEKE------YSQEVPQVKPWEKVSGPPVL 277
            |.:..|..||::.|:::|||||.||..||:..::.:|..      |.||....||.|:...||:|
Human   142 VTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPIL 206

  Fly   278 PPHLLQVILNKDTPLSCEPTLLPEPNHVMLNHLYALSIKDGVMVLSATHRYRKKYVTTLLYKPI 341
            |||||||||||||.:||:|.|||||||||||||||||||||||||||||||:||||||||||||
Human   207 PPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alc	NP_610460.1	AMPK1_CBM	156..238	CDD:293169	44/81 (54%)
alc	NP_610460.1	AMPKBI	254..341	CDD:214973	67/92 (73%)
PRKAB1	NP_006244.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43
		Glycogen-binding domain. /evidence=ECO:0000250	68..163		47/85 (55%)
		AMPK1_CBM	78..161	CDD:406865	44/82 (54%)
		AMPKBI	181..270	CDD:214973	66/88 (75%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141889
Domainoid	1	1.000	133	1.000	Domainoid score	I5071
eggNOG	1	0.900	-	-		E1_KOG1616
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38160
Inparanoid	1	1.050	255	1.000	Inparanoid score	I3177
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D511710at33208
OrthoFinder	1	1.000	-	-		FOG0001107
OrthoInspector	1	1.000	-	-		otm40631
orthoMCL	1	0.900	-	-		OOG6_101253
Panther	1	1.100	-	-	LDO	PTHR10343
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1739
SonicParanoid	1	1.000	-	-		X946
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790