DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hydr1 and ABHD1

DIOPT Version :9

Sequence 1:	NP_001188892.1	Gene:	Hydr1 / 35930	FlyBaseID:	FBgn0033382	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_115993.3	Gene:	ABHD1 / 84696	HGNCID:	17553	Length:	405	Species:	Homo sapiens

Alignment Length:	386	Identity:	155/386 - (40%)
Similarity:	225/386 - (58%)	Gaps:	24/386 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 VLGMAVVAYVVYYLIQVVKRPIIACSDGP-FKQYLIRKVPTLENKYWPTFWCVESRAQTVLASLL 167
            :|.:||..|:.||...|::||.:..  || |..:|..........::||.||.|.|.|::...||
Human    20 LLALAVALYLGYYWACVLQRPRLVA--GPQFLAFLEPHCSITTETFYPTLWCFEGRLQSIFQVLL 82

  Fly   168 RSKSLPRVNYRREILSLKDGGEVALDWMEEGCDQS-------APCILILPGLTGESQAEYIKCLV 225
            :|:  |.|.|:.:||...|||::.|||.::. |.|       .|.:|:|||:||.||..|:..||
Human    83 QSQ--PLVLYQSDILQTPDGGQLLLDWAKQP-DSSQDPDPTTQPIVLLLPGITGSSQETYVLHLV 144

  Fly   226 FAAQQAGMRVVVFNNRGLGGIELKTPRLYCAANCEDLCEVVQHVRRTLPEKCKLGATGISMGGLI 290
            ..|.:.|.:.|||||||..|.||:|.|.:||:|.|||..||.|::...|: ..|.|.|||.||::
Human   145 NQALRDGYQAVVFNNRGCRGEELRTHRAFCASNTEDLETVVNHIKHRYPQ-APLLAVGISFGGIL 208

  Fly   291 LGNYLARKSDEARSFLSAAKIISVPWDVHKGSASIEKPVINSLLGRHLAGSLCRTLRNHLDIYRD 355
            :.|:||:....|.  |.||..:|..||..:.:.|:|.|:.:.|..:.|...||:.:..:..:...
Human   209 VLNHLAQARQAAG--LVAALTLSACWDSFETTRSLETPLNSLLFNQPLTAGLCQLVERNRKVIEK 271

  Fly   356 IYQDSDIDIQRILRCKTIKEFDALFTAKQFGYAHVNDYYSDATLHNKLDHISVPLLCLSAADDPF 420
            :     :||..:|:.:||::||..:|:..|||.....||..|:...|:|.|.:|:|.||||||||
Human   272 V-----VDIDFVLQARTIRQFDERYTSVAFGYQDCVTYYKAASPRTKIDAIRIPVLYLSAADDPF 331

  Fly   421 QPLDAIPIKAANQCTHVAIVITARGGHIGFLEGWWPSTKDQYMGRLFTEYFTKALF-DEDG 480
            .|:.|:||:||....:||::|||||||||||||..| .:..||.||..:| .||:| |.:|
Human   332 SPVCALPIQAAQHSPYVALLITARGGHIGFLEGLLP-WQHWYMSRLLHQY-AKAIFQDPEG 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hydr1	NP_001188892.1	Abhydrolase	140..455	CDD:304388	131/321 (41%)
Hydr1	NP_001188892.1	Abhydrolase_1	206..453	CDD:278959	105/246 (43%)
ABHD1	NP_115993.3	Abhydrolase	46..377	CDD:304388	138/342 (40%)
ABHD1	NP_115993.3	Abhydrolase_1	123..364	CDD:278959	106/248 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148060
Domainoid	1	1.000	195	1.000	Domainoid score	I3156
eggNOG	1	0.900	-	-		E1_COG0429
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	276	1.000	Inparanoid score	I2961
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53891
OrthoDB	1	1.010	-	-		D1162019at2759
OrthoFinder	1	1.000	-	-		FOG0001372
OrthoInspector	1	1.000	-	-		otm41770
orthoMCL	1	0.900	-	-		OOG6_100540
Panther	1	1.100	-	-	LDO	PTHR10794
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2183
SonicParanoid	1	1.000	-	-		X867
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800