DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hydr1 and abhd3

DIOPT Version :9

Sequence 1:	NP_001188892.1	Gene:	Hydr1 / 35930	FlyBaseID:	FBgn0033382	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_001004569.1	Gene:	abhd3 / 447830	ZFINID:	ZDB-GENE-040912-90	Length:	412	Species:	Danio rerio

Alignment Length:	398	Identity:	176/398 - (44%)
Similarity:	239/398 - (60%)	Gaps:	27/398 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 YLSNLPRLHVLGMAV---------VAYVVYYLIQVVKRPIIACSDGPFKQYLIRKVPTLENKYWP 150
            ||.|..::.:.|..|         .||..||||.|.|:|::......|.|:|..:.|.:...|:|
Zfish    18 YLKNQVKVGLFGSGVGLSVVLGFSAAYACYYLISVAKKPLLIAGGNKFHQFLRDQCPVVSETYYP 82

  Fly   151 TFWCVESRAQTVLASLLRSKSLPRVNYRREILSLKDGGEVALDWMEEG-----CDQSA-PCILIL 209
            ||||.|||.||:|...:.:|  |.||||.|::...|||:::|||.:..     .|||. |.:|:|
Zfish    83 TFWCWESRVQTLLRPFVTAK--PWVNYRNELIRAPDGGQISLDWFDNDDSVSHPDQSTRPTVLLL 145

  Fly   210 PGLTGESQAEYIKCLVFAAQQAGMRVVVFNNRGLGGIELKTPRLYCAANCEDLCEVVQHVRRTLP 274
            |||||.|:..||..:|..::..|.|.|||||||:.|.:|.|||.|||||.|||..|::||:||:
Zfish   146 PGLTGTSRESYILHMVQQSRDLGYRCVVFNNRGVSGEKLLTPRTYCAANTEDLEVVIEHVQRTI- 209

  Fly   275 EKCKLGATGISMGGLILGNYLARKSDEARSFLSAAKIISVPWDVHKGSASIEKPVINSLLGRHLA 339
            .|..|.|.|:||||::|.|||.||..|.|  |....:.|..|||.:.:||:|||:...|...:|.
Zfish   210 NKAPLMAAGVSMGGMMLANYLGRKGSEVR--LKGVVVFSAGWDVFECTASLEKPLDRFLFNSYLT 272

  Fly   340 GSLCRTLRNHLDIYRDIYQDSDIDIQRILRCKTIKEFDALFTAKQFGYAHVNDYYSDATLHNKLD 404
            ..|..::..|..|....|     ||..:::.|||:|||..||:..|||...:|||.||:..:|:.
Zfish   273 SCLQASVDRHRTILEKKY-----DIDHVMKAKTIREFDERFTSIMFGYPSNDDYYRDASPIHKVK 332

  Fly   405 HISVPLLCLSAADDPFQPLDAIPIKAANQCTHVAIVITARGGHIGFLEGWWPSTKDQYMGRLFTE 469
            .:.||:|||:||||.|.|..|||::|..|...||::||..|||||||||.|| .:..||.|:|.:
Zfish   333 SVQVPMLCLNAADDVFSPNHAIPVEAVKQNPSVALLITCHGGHIGFLEGLWP-RQSTYMDRVFRQ 396

  Fly   470 YFTKALFD 477
             ||||:|:
Zfish   397 -FTKAVFE 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hydr1	NP_001188892.1	Abhydrolase	140..455	CDD:304388	148/320 (46%)
Hydr1	NP_001188892.1	Abhydrolase_1	206..453	CDD:278959	116/246 (47%)
abhd3	NP_001004569.1	PLN02511	37..406	CDD:215282	171/379 (45%)
abhd3	NP_001004569.1	Abhydrolase	76..404	CDD:304388	158/340 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581978
Domainoid	1	1.000	124	1.000	Domainoid score	I5490
eggNOG	1	0.900	-	-		E1_COG0429
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14055
Inparanoid	1	1.050	317	1.000	Inparanoid score	I2527
OMA	1	1.010	-	-		QHG53891
OrthoDB	1	1.010	-	-		D1162019at2759
OrthoFinder	1	1.000	-	-		FOG0001372
OrthoInspector	1	1.000	-	-		oto40415
orthoMCL	1	0.900	-	-		OOG6_100540
Panther	1	1.100	-	-	O	PTHR10794
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2183
SonicParanoid	1	1.000	-	-		X867
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800