DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hydr1 and abhd2a

DIOPT Version :9

Sequence 1:	NP_001188892.1	Gene:	Hydr1 / 35930	FlyBaseID:	FBgn0033382	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_957208.1	Gene:	abhd2a / 393888	ZFINID:	ZDB-GENE-040426-784	Length:	432	Species:	Danio rerio

Alignment Length:	424	Identity:	102/424 - (24%)
Similarity:	175/424 - (41%)	Gaps:	57/424 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 VRSLHSENDAMFYSMYAYLSNLPRLHVLGMAVVAYVVYYLIQVVK------RPIIACSDGPFKQY 136
            |.::..|..|||..|             .:|.||.|:|.:::.:.      .|.:...|.....:
Zfish     8 VYTVAPEMPAMFDGM-------------KLAAVATVLYVIVRCLNLKSPTAPPDLTFQDTTLNHF 59

  Fly   137 LIRKVPTLENKYW-PTFWCVESRAQTVLASLLRSKSLPRVNYRREILSLKDGGEVALDWMEEGCD 200
            |::..|.|..:|. |..|......||.|...|...|.|.....|:.|.::||.....|..|...|
Zfish    60 LLKSCPILTKEYIPPLLWGKSGHLQTALYGKLGRVSSPHPFGLRKYLPMQDGATATFDLFEPLAD 124

  Fly   201 QSA---PCILILPGLTGESQAEYIKCLVFAAQQAGMRVVVFNNRG-LGGIELKTPRLYCAANCED 261
            ..:   ..::|.||:...|:..||:..|..:|:.|.|..|.|:.| |..|||.:||::......:
Zfish   125 HQSGEDVTMVICPGIGNHSEKHYIRTFVDHSQKQGYRCAVLNHLGALPNIELTSPRMFTYGCTWE 189

  Fly   262 LCEVVQHVRRTLPEKCKLGATGISMGGLILGNYLARKSDEARSFLSAAKIIS-----------VP 315
            ...:|..:::|.|:. ||...|.|:||.|:..:|..........|....:..           :.
Zfish   190 FAAMVGFIKKTYPQS-KLIVVGFSLGGNIVCKFLGENRTNQERVLCCVSVCQGYSALRAQETFLQ 253

  Fly   316 WDVHKGSASIEKPVINSLLGRHLAGSLCRTLRNHLDIYRDIYQDS-DIDIQRILRCKTIKEFDAL 379
            ||..       :...|.|    :|.::.:.:.:|..:...:.... |.::.|:....::.:.|..
Zfish   254 WDQC-------RRFYNFL----MADNMKKIILSHRGVLFGVGSKMVDSELSRLYTATSLMQIDDN 307

  Fly   380 FTAKQFGYAHVNDYYSDATLHNKLDHISVPLLCLSAADDPF--QPLDAIPIKAANQCTHVAIVIT 442
            ...|..|:..:.:||...:..:.:.:|:||||.:::.|||.  ..|..||...|.:..:|...:|
Zfish   308 IMRKFHGHNSLKEYYEKESCVHYIHNINVPLLLVNSVDDPLVHNSLLTIPRTLAEKKENVVFALT 372

  Fly   443 ARGGHIGFLEGW----WPSTKDQYMGRLFTEYFT 472
            ..|||:||.||.    .|.|   :|.::..:|.|
Zfish   373 LHGGHLGFFEGAVLFPQPLT---WMDKVIVDYAT 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hydr1	NP_001188892.1	Abhydrolase	140..455	CDD:304388	83/337 (25%)
Hydr1	NP_001188892.1	Abhydrolase_1	206..453	CDD:278959	63/261 (24%)
abhd2a	NP_957208.1	Abhydrolase	52..401	CDD:389770	88/363 (24%)
abhd2a	NP_957208.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	413..432
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0429
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53891
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820