Protein Alignment Hydr1 and ABHD3

DIOPT Version :9

• Sequence 1: NP_001188892.1
• Gene: Hydr1 / 35930
• FlyBaseID: FBgn0033382
• Length: 525
• Species: Drosophila melanogaster
• Sequence 2: NP_612213.2
• Gene: ABHD3 / 171586
• HGNCID: 18718
• Length: 409
• Species: Homo sapiens
• Alignment Length: 432
• Identity: 162/432 - (37%)
• Similarity: 236/432 - (54%)
• Gaps: 43/432 - (9%)

  Fly    65 LSLSRPALSSKLSVRSLHSENDAMFYSMYAYLSNLPRLHVLGMAV---------VAYVVYYLIQV 120
            |::....||.:||:                ||.:..|:...|..|         |||..|||..:
Human     4 LAMDLRMLSRELSL----------------YLEHQVRVGFFGSGVGLSLILGFSVAYAFYYLSSI 52

  Fly   121 VKRPIIACSDGPFKQYLIRKVPTLENKYWPTFWCVESRAQTVLASLLRSKSLPRVNYRREILSLK 185
            .|:|.:......|.::|....|.:...|:||.||.|.|.||:|...:.||  |.|.||.|::...
Human    53 AKKPQLVTGGESFSRFLQDHCPVVTETYYPTVWCWEGRGQTLLRPFITSK--PPVQYRNELIKTA 115

  Fly   186 DGGEVALDWMEEG---CDQSA---PCILILPGLTGESQAEYIKCLVFAAQQAGMRVVVFNNRGLG 244
            |||:::|||.:..   |...|   |.||:||||||.|:..||..::..:::.|.|.|||||||:.
Human   116 DGGQISLDWFDNDNSTCYMDASTRPTILLLPGLTGTSKESYILHMIHLSEELGYRCVVFNNRGVA 180

  Fly   245 GIELKTPRLYCAANCEDLCEVVQHVRRTLPEKCKLGATGISMGGLILGNYLARKSDEARSFLSAA 309
            |..|.|||.||.||.|||..|:.||....|....| |.|:||||::|.|||.:..  :::.|.||
Human   181 GENLLTPRTYCCANTEDLETVIHHVHSLYPSAPFL-AAGVSMGGMLLLNYLGKIG--SKTPLMAA 242

  Fly   310 KIISVPWDVHKGSASIEKPVINSLLGRHLAGSLCRTLRNHLDIYRDIYQDSDIDIQRILRCKTIK 374
            ...||.|:....|.|:|||:...|...:|...|..::..|..::     ...:|:..:::.|:|:
Human   243 ATFSVGWNTFACSESLEKPLNWLLFNYYLTTCLQSSVNKHRHMF-----VKQVDMDHVMKAKSIR 302

  Fly   375 EFDALFTAKQFGYAHVNDYYSDATLHNKLDHISVPLLCLSAADDPFQPLDAIPIKAANQCTHVAI 439
            |||..||:..|||..::|||:||:...:|..:.:|:|||::.||.|.|..||||:.|.|..:||:
Human   303 EFDKRFTSVMFGYQTIDDYYTDASPSPRLKSVGIPVLCLNSVDDVFSPSHAIPIETAKQNPNVAL 367

  Fly   440 VITARGGHIGFLEGWWPSTKDQYMGRLFTEYFTKALFDEDGE 481
            |:|:.|||||||||.|| .:..||.|:|.: |.:|:.:...|
Human   368 VLTSYGGHIGFLEGIWP-RQSTYMDRVFKQ-FVQAMVEHGHE 407

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hydr1	NP_001188892.1	Abhydrolase	140..455	CDD:304388	133/320 (42%)
		Abhydrolase_1	206..453	CDD:278959	104/246 (42%)
ABHD3	NP_612213.2	PLN02511	39..403	CDD:215282	151/375 (40%)
		Abhydrolase	92..398	CDD:304388	131/317 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148059
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0429
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14055
Inparanoid	1	1.050	276	1.000	Inparanoid score	I2961
Isobase	1	0.950	-	0	Normalized mean entropy	S2599
OMA	1	1.010	-	-		QHG53891
OrthoDB	1	1.010	-	-		D1162019at2759
OrthoFinder	1	1.000	-	-		FOG0001372
OrthoInspector	1	1.000	-	-		otm41770
orthoMCL	1	0.900	-	-		OOG6_100540
Panther	1	1.100	-	-	O	PTHR10794
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2183
SonicParanoid	1	1.000	-	-		X867
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.750